Rapamycin-Loaded Lipid Nanocapsules Induce Selective Inhibition of the mTORC1-Signaling Pathway in Glioblastoma Cells

Autor: Delphine Séhédic, Loris Roncali, Amel Djoudi, Nela Buchtova, Sylvie Avril, Michel Chérel, Frank Boury, Franck Lacoeuille, François Hindré, Emmanuel Garcion

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)

Inhibition of the PI3K/Akt/mTOR signaling pathway represents a potential issue for the treatment of cancer, including glioblastoma. As such, rapamycin that inhibits the mechanistic target of rapamycin (mTOR), the downstream effector of this signaling

Externí odkaz: https://doaj.org/article/7c81110c7cf344ad983d8b3c79d577c7

Rhenium-188 Labeled Radiopharmaceuticals: Current Clinical Applications in Oncology and Promising Perspectives

Autor: Nicolas Lepareur, Franck Lacœuille, Christelle Bouvry, François Hindré, Emmanuel Garcion, Michel Chérel, Nicolas Noiret, Etienne Garin, F. F. Russ Knapp

Publikováno v: Frontiers in Medicine, Vol 6 (2019)

Rhenium-188 (188Re) is a high energy beta-emitting radioisotope with a short 16.9 h physical half-life, which has been shown to be a very attractive candidate for use in therapeutic nuclear medicine. The high beta emission has an average energy of 78

Externí odkaz: https://doaj.org/article/83331741e4d649dcb836981949644ca0

68Ga and 188Re Starch-Based Microparticles as Theranostic Tool for the Hepatocellular Carcinoma: Radiolabeling and Preliminary In Vivo Rat Studies.

Autor: Elise Verger, Pierre Drion, Geneviève Meffre, Claire Bernard, Luc Duwez, Nicolas Lepareur, Olivier Couturier, François Hindré, Roland Hustinx, Franck Lacoeuille

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0164626 (2016)

This work aims to develop, validate and optimize the radiolabeling of Starch-Based Microparticles (SBMP) by 188Re and 68Ga in the form of ready-to-use radiolabeling kits, the ultimate goal being to obtain a unique theranostic vector for the treatment

Externí odkaz: https://doaj.org/article/073c6ee3a6e640ceaee099556e1b7725

Calibration test of PET scanners in a multi-centre clinical trial on breast cancer therapy monitoring using 18F-FLT.

Autor: Francis Bouchet, Lilli Geworski, Bernd O Knoop, Ludovic Ferrer, Alina Barriolo-Riedinger, Corinne Millardet, Marjolaine Fourcade, Antoine Martineau, Anne Belly-Poinsignon, Francis Djoumessi, Karine Tendero, Laurent Keros, Frederic Montoya, Christel Mesleard, Anne-Laure Martin, Franck Lacoeuille, Olivier Couturier

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58152 (2013)

A multi-centre trial using PET requires the analysis of images acquired on different systems We designed a multi-centre trial to estimate the value of 18F-FLT-PET to predict response to neoadjuvant chemotherapy in patients with newly diagnosed breast

Externí odkaz: https://doaj.org/article/1a480d60fbea41c4a40169a6b01b46d0

Prognostic Value of Metabolic, Volumetric and Textural Parameters of Baseline [18F]FDG PET/CT in Early Triple-Negative Breast Cancer

Autor: Clément Bouron, Clara Mathie, Valérie Seegers, Olivier Morel, Pascal Jézéquel, Hamza Lasla, Camille Guillerminet, Sylvie Girault, Marie Lacombe, Avigaelle Sher, Franck Lacoeuille, Anne Patsouris, Aude Testard

Publikováno v: Cancers, Vol 14, Iss 637, p 637 (2022)
Cancers
Cancers, 2022, 14 (3), pp.637. ⟨10.3390/cancers14030637⟩
Cancers; Volume 14; Issue 3; Pages: 637

(1) Background: triple-negative breast cancer (TNBC) remains a clinical and therapeutic challenge primarily affecting young women with poor prognosis. TNBC is currently treated as a single entity but presents a very diverse profile in terms of progno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d105257dfdb23d8d1188ad1f015fbd
https://www.mdpi.com/2072-6694/14/3/637