Výsledky vyhledávání - "FPN, ferroportin"

Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance

Autor: Yan Wang, Yalin Wu, Zuguo Liu, Jingmeng Chen, Chao Chen

Publikováno v: The Journal of Biological Chemistry

The death of photoreceptor cells in dry age-related macular degeneration (AMD) and autosomal recessive Stargardt disease (STGD1) is closely associated with disruption in all-trans-retinal (atRAL) clearance in neural retina. In this study, we reveal t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e528672cccb4554ebf9c4e807e79212a
https://pubmed.ncbi.nlm.nih.gov/33334878

Zobrazit plný text záznamu

Iron Prevents Hypoxia-Associated Inflammation Through the Regulation of Nuclear Factor-κB in the Intestinal Epithelium

Autor: Simona Simmen, Jesus Cosin-Roger, Cheryl de Valliere, Katharina Spanaus, Katharina Baebler, Chiaki Maeyashiki, Nikolaos Maliachovas, Jonas Zeitz, Gerhard Rogler, Pedro A. Ruiz, Hassan Melhem, Stephan R. Vavricka, Bruce Weder, Max Maane, Martin Hausmann, Michael Scharl

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 2, Pp 339-355 (2019)

Background & Aims: Hypoxia-associated pathways influence the development of inflammatory bowel disease. Adaptive responses to hypoxia are mediated through hypoxia-inducible factors, which are regulated by iron-dependent hydroxylases. Signals reflecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b468eae5dd78052ab560274d719c8cf0
http://europepmc.org/articles/PMC6357696

Zobrazit plný text záznamu

Dynamics of absorption, metabolism, and excretion of 5-aminolevulinic acid in human intestinal Caco-2 cells

Autor: Shunsuke Hatta, Satoshi Ichikawa, Yasushi Onishi, Urara Ota, Noriko Fukuhara, Yoko Okitsu, Masahiro Kobayashi, Hideo Harigae, Kei Saito, Tohru Fujiwara, Tohru Tanaka, Masahiro Ishizuka

Publikováno v: Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 11, Iss C, Pp 105-111 (2017)

5-Aminolevulinic acid (ALA) is a precursor for the biosynthesis of porphyrins and heme. Although the oral administration of ALA has been widely applied in clinical settings, the dynamics of its absorption, metabolism, and excretion within enterocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b82a9f47aca64455eb73801bac9a6a
https://pubmed.ncbi.nlm.nih.gov/28955775

Zobrazit plný text záznamu

Curcumin may impair iron status when fed to mice for six months

Autor: Patricia Huebbe, Jan Frank, Kathrin Pallauf, Dawn Chin, Gerald Rimbach

Publikováno v: Redox Biology, Vol 2, Iss C, Pp 563-569 (2014)
Redox Biology

Curcumin has been shown to have many potentially health beneficial properties in vitro and in animal models with clinical studies on the toxicity of curcumin reporting no major side effects. However, curcumin may chelate dietary trace elements and co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34111eb52cef8c02b7b58ec3fd7d6591
http://www.sciencedirect.com/science/article/pii/S2213231714000330

Zobrazit plný text záznamu

Hepcidin: regulation of the master iron regulator

Autor: Gautam Rishi, Daniel F. Wallace, V. Nathan Subramaniam

Publikováno v: Bioscience Reports
Bioscience Reports, Vol 35, Iss 3, p e00192 (2015)

Iron, an essential nutrient, is required for many diverse biological processes. The absence of a defined pathway to excrete excess iron makes it essential for the body to regulate the amount of iron absorbed; a deficiency could lead to iron deficienc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6358457def4b1c58d16c877af1c35152
https://doi.org/10.1042/bsr20150014

Zobrazit plný text záznamu

Heme Exporter FLVCR1a Regulates Heme Synthesis and Degradation and Controls Activity of Cytochromes P450

Autor: Giada Ingoglia, Fiorella Altruda, Lorenzo Silengo, Sonia Mercurio, Emanuela Tolosano, Deborah Chiabrando, Francesca Vinchi, Emilia Turco

Publikováno v: Gastroenterology

Background & Aims The liver has one of the highest rates of heme synthesis of any organ. More than 50% of the heme synthesized in the liver is used for synthesis of P450 enzymes, which metabolize exogenous and endogenous compounds that include natura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5067ade43b092e13b386c129d0b91fe3
http://hdl.handle.net/2318/146913

Zobrazit plný text záznamu

Akademický článek

Dynamics of absorption, metabolism, and excretion of 5-aminolevulinic acid in human intestinal Caco-2 cells.

Autor: Saito K; Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan., Fujiwara T; Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan., Ota U; SBI Pharmaceuticals Co., Ltd., Tokyo, Japan., Hatta S; Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan., Ichikawa S; Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan., Kobayashi M; Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan., Okitsu Y; Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan., Fukuhara N; Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan., Onishi Y; Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan., Ishizuka M; SBI Pharmaceuticals Co., Ltd., Tokyo, Japan., Tanaka T; SBI Pharmaceuticals Co., Ltd., Tokyo, Japan., Harigae H; Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Publikováno v: Biochemistry and biophysics reports [Biochem Biophys Rep] 2017 Jul 13; Vol. 11, pp. 105-111. Date of Electronic Publication: 2017 Jul 13 (Print Publication: 2017).

Zobrazit plný text záznamu

Akademický článek

Maternal protein restriction depresses the duodenal expression of iron transporters and serum iron level in male weaning piglets.

Autor: Ma W; 1Key Laboratory of Animal Physiology and Biochemistry,College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,People's Republic of China., Lu J; 1Key Laboratory of Animal Physiology and Biochemistry,College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,People's Republic of China., Jiang S; 1Key Laboratory of Animal Physiology and Biochemistry,College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,People's Republic of China., Cai D; 1Key Laboratory of Animal Physiology and Biochemistry,College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,People's Republic of China., Pan S; 1Key Laboratory of Animal Physiology and Biochemistry,College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,People's Republic of China., Jia Y; 1Key Laboratory of Animal Physiology and Biochemistry,College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,People's Republic of China., Zhao R; 1Key Laboratory of Animal Physiology and Biochemistry,College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,People's Republic of China.

Publikováno v: The British journal of nutrition [Br J Nutr] 2017 Apr; Vol. 117 (7), pp. 923-929.

Zobrazit plný text záznamu

Akademický článek

Curcumin may impair iron status when fed to mice for six months.

Autor: Chin D; Institute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Hermann-Rodewald-Strasse 6-8, D-24118 Kiel, Germany., Huebbe P; Institute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Hermann-Rodewald-Strasse 6-8, D-24118 Kiel, Germany., Frank J; Institute of Biological Chemistry and Nutrition, University of Hohenheim, Garbenstrasse 28, D-70599 Stuttgart, Germany., Rimbach G; Institute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Hermann-Rodewald-Strasse 6-8, D-24118 Kiel, Germany., Pallauf K; Institute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Hermann-Rodewald-Strasse 6-8, D-24118 Kiel, Germany.

Publikováno v: Redox biology [Redox Biol] 2014 Feb 28; Vol. 2, pp. 563-9. Date of Electronic Publication: 2014 Feb 28 (Print Publication: 2014).

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání