Zobrazeno 1 - 10
of 3 043
pro vyhledávání: '"FOXO3A"'
Lauric acid reduces apoptosis by inhibiting FOXO3a-signaling in deoxynivalenol-treated IPEC-J2 cells
Autor:
Na Yeon Kim, Sang In Lee
Publikováno v:
Journal of Animal Science and Technology, Vol 66, Iss 5, Pp 1010-1020 (2024)
Deoxynivalenol (DON) is the most common mycotoxin contaminant of food or feed worldwide and causes disease in animals. Lauric acid (LA) is a medium-chain fatty acid useful for barrier functions such as antimicrobial activity in the intestine of monog
Externí odkaz:
https://doaj.org/article/48eff5350082472d8e4cfd7dc2bded17
Autor:
Dominika Ewa Habrowska-Górczyńska, Marta Justyna Kozieł, Kinga Anna Urbanek, Karolina Kowalska, Agnieszka Wanda Piastowska-Ciesielska
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Zearalenone (ZEN), an estrogenic mycotoxin, is one of the most common food and feed contaminants. Also, its metabolites α-zearalenol (α-ZEL) and β-zearalenol (β-ZEL) are considered to induce oxidative stress, however its effect in prosta
Externí odkaz:
https://doaj.org/article/11b4c04aca9b4065acf7fbe090acc9d2
Akademický článek
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Autor:
Jie Dong, Lingkai Kong, Shiqun Wang, Mao Xia, Yenan Zhang, Jingyi Wu, Fuming Yang, Shuguang Zuo, Jiwu Wei
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-23 (2024)
Abstract Background Dysregulation of cholesterol metabolism is associated with the metastasis of triple-negative breast cancer (TNBC). Apolipoprotein A1 (ApoA1) is widely recognized for its pivotal role in regulating cholesterol efflux and maintainin
Externí odkaz:
https://doaj.org/article/461caec5fead425fad0d4e72172eac98
Publikováno v:
Brain Research Bulletin, Vol 219, Iss , Pp 111129- (2024)
Background: Euphorbiasteroid, a bioactive compound from Euphorbia lathyris L., exhibits significant pharmacological effects, including anti-tumor activity and multi-drug resistance reversal. However, its potential neurotoxicity limits its clinical us
Externí odkaz:
https://doaj.org/article/95d9dcd74aa1413080a04100aefd8601
Publikováno v:
Translational Oncology, Vol 46, Iss , Pp 101999- (2024)
Purpose: TRIM6, an E3 ubiquitin ligase with tripartite motif, directly targets protein substrates for degradation through ubiquitination. Studies have shown that TRIM6 plays a significant role in tumor development in various human malignancies. Thus,
Externí odkaz:
https://doaj.org/article/0b2df92581d048c685b0eff77f162279
Autor:
Yui Iwatani, Hideki Hayashi, Haruno Oba, Maho Oba, Ann Sawamura, Yoshiyuki Moriyama, Norio Takagi
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116778- (2024)
The incidence of cerebral infarction triggered by abnormal glucose tolerance has increased; however, the relationship between glucose concentration in the brain and the detailed mechanism of post ischemic cell death remains unclear. Nicotinamide phos
Externí odkaz:
https://doaj.org/article/6af1051699dd413b92a434a1490e6e39
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Cognitive impairment (COI) is a prevalent complication across a spectrum of brain disorders, underpinned by intricate mechanisms yet to be fully elucidated. Neurons, the principal cell population of the nervous system, orchestrate cognitive processes
Externí odkaz:
https://doaj.org/article/d3c7315205d4473889b8dfdb51b0420b
Publikováno v:
Journal of Men's Health, Vol 20, Iss 2, Pp 126-134 (2024)
Placenta-specific protein 1 (PLAC1) is considered to play a pivotal role in cancer progression. Here, we investigated the role of PLAC1 in the growth and motility of bladder cancer (BCa) cells. Database analysis and Immunoblot assays were conducted t
Externí odkaz:
https://doaj.org/article/be514f117e374996a624f7182d68dfa5
Autor:
Zhe Chen, Qian Guo, Shichen Huang, Lei Li, Feng Wu, Zhilong Liu, Zhigang Li, Tao Chen, Guanbin Song, Shuangnian Xu, Jieping Chen, Yu Hou
Publikováno v:
Genes and Diseases, Vol 11, Iss 1, Pp 397-412 (2024)
Therapeutic targeting FOXO3A (a forkhead transcription factor) represents a promising strategy to suppress acute myeloid leukemia (AML). However, the effective inhibitors that target FOXO3A are lacking and the adaptive response signaling weakens the
Externí odkaz:
https://doaj.org/article/b33e1bcc6d044eb48a488a7c6821576b