Zobrazeno 1 - 10
of 15
pro vyhledávání: '"FOXO3, forkhead box O3"'
Publikováno v:
International Immunopharmacology
SARS-CoV-2, as the causative agent of COVID-19, is an enveloped positives-sense single-stranded RNA virus that belongs to the Beta-CoVs sub-family. A sophisticated hyper-inflammatory reaction named cytokine storm is occurred in patients with severe/c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4706f42d886bb679ed2a6b85453a9c
https://pubmed.ncbi.nlm.nih.gov/34601331
https://pubmed.ncbi.nlm.nih.gov/34601331
Autor:
Masoumeh Tavakoli-Yaraki, Vahid Salimi, Mostafa Ibrahimi, Zahra Rampisheh, Mehrdad Bahrabadi, Pegah Babaheidarian, Ameinh Hosseini, Fatemeh Hosami, Alireza Mirzaei, Zohreh Abdolvahabi, Khodamorad Jamshidi, Soudabeh Fallah, Narges Khademian
Publikováno v:
Journal of Bone Oncology, Vol 23, Iss, Pp 100300-(2020)
Journal of Bone Oncology
Journal of Bone Oncology
Highlights • The SOX9 expression increased in tumor tissues and peripheral blood of malignant and benign bone tumors. • The protein level of SOX9 is enhanced in malignant bone tumor tissues. • SOX9 over-expression correlated with tumor severity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81383c3f75a7f37062761a0cf54f0a7
http://www.sciencedirect.com/science/article/pii/S2212137420300555
http://www.sciencedirect.com/science/article/pii/S2212137420300555
Autor:
Zimam Mahmud, Yannasittha Jiramongkol, Kitti Intuyod, Glowi Alasiri, Eric Lam, Huiling Ke, Sasanan Trakansuebkul
Publikováno v:
Molecular and Cellular Endocrinology
Pharmaceutical inhibitors of the endoplasmic reticulum (ER)-stress modulator PERK (eIF2AK3) have demonstrated anticancer activities in combination therapies, but their effectiveness as a single agent is limited, suggesting the existence of possible c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1090678c396ca7581be72c83fc88f1e9
http://hdl.handle.net/10044/1/81106
http://hdl.handle.net/10044/1/81106
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 132, Iss, Pp 110886-(2020)
Biomedicine & Pharmacotherapy
Biomedicine & Pharmacotherapy
Graphical abstract
Highlights • CS triggered by excessive inflammatory response drives the pathogenesis of COVID-19. • ASX inhibits TNFα, IL1β, IL6 via regulation of NF-kB & JAK/STAT; prevents CS & ALI/ARDS. • ASX suppresses plasma CRP,
Highlights • CS triggered by excessive inflammatory response drives the pathogenesis of COVID-19. • ASX inhibits TNFα, IL1β, IL6 via regulation of NF-kB & JAK/STAT; prevents CS & ALI/ARDS. • ASX suppresses plasma CRP,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd7bf3aa8d9fd5d6f23a47947a5470c
https://pubmed.ncbi.nlm.nih.gov/33113418
https://pubmed.ncbi.nlm.nih.gov/33113418
Autor:
Cory S. Wagg, Jeff D. Reagan, John R. Ussher, Liyan Zhang, Kenneth Milner, Dongming M. Liu, Angela Fu, Alykhan Motani, Abhishek Gupta, Osama Abo Alrob, Chaves Mary, Nikole J. Byrne, Natasha Fillmore, Pavan K. Battiprolu, Arata Fukushima, Shaohua Wang, Gary D. Lopaschuk, Khanh Nguyen, Wei Wang, Jun Mori, Tariq R. Altamimi, Jenny Ying-Lin Lu, Jason R.B. Dyck
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 385-400 (2019)
JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 385-400 (2019)
Visual Abstract
Highlights • MCD inhibition decreases fatty acid oxidation via increasing malonyl coenzyme A levels to prevent fatty acid uptake into mitochondria in the failing hearts induced by coronary artery ligation. • Downregulating fa
Highlights • MCD inhibition decreases fatty acid oxidation via increasing malonyl coenzyme A levels to prevent fatty acid uptake into mitochondria in the failing hearts induced by coronary artery ligation. • Downregulating fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074f5ff29e2376a91baabc9d38b612d8
https://pubmed.ncbi.nlm.nih.gov/31312761
https://pubmed.ncbi.nlm.nih.gov/31312761
Autor:
John Y.L. Chiang, Jessica M. Ferrell
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 5, Iss 2, Pp 113-122 (2015)
Acta Pharmaceutica Sinica B, Vol 5, Iss 2, Pp 113-122 (2015)
Mounting research evidence demonstrates a significant negative impact of circadian disruption on human health. Shift work, chronic jet lag and sleep disturbances are associated with increased incidence of metabolic syndrome, and consequently result i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8694c3a420c6177ab77df19b950020b0
http://europepmc.org/articles/PMC4629216
http://europepmc.org/articles/PMC4629216
Autor:
Marie J. Parsons, Simon Keely
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Diminished forkhead box O3 (FOXO3) function drives inflammation and cancer growth; however, mechanisms fostering these pathobiologies are unclear. Here, we aimed to identify in colon loss of FOXO3-dependent cellular and molecular ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c5e0cc81fda1535158b0f6b1fc6389
https://doi.org/10.1016/j.jcmgh.2018.11.003
https://doi.org/10.1016/j.jcmgh.2018.11.003
Akademický článek
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Autor:
Esteban-Lopez M; Departments of Human and Molecular Genetics, Florida International University, Miami, FL 33199, USA., Perry MD; Immunology and Nano-medicine, Florida International University, Miami, FL 33199, USA., Garbinski LD; Cell Biology and Pharmacology and Florida International University, Miami, FL 33199, USA., Manevski M; Immunology and Nano-medicine, Florida International University, Miami, FL 33199, USA., Andre M; Immunology and Nano-medicine, Florida International University, Miami, FL 33199, USA., Ceyhan Y; Departments of Human and Molecular Genetics, Florida International University, Miami, FL 33199, USA., Caobi A; Immunology and Nano-medicine, Florida International University, Miami, FL 33199, USA., Paul P; Translational Glycobiology, Florida International University, Miami, FL 33199, USA., Lau LS; Translational Glycobiology, Florida International University, Miami, FL 33199, USA., Ramelow J; Herbert Wertheim College of Medicine, Biological Sciences in the College of Arts, Science and Education and the Biomolecular Sciences Institute, Florida International University, Miami, FL 33199, USA., Owens F; Immunology and Nano-medicine, Florida International University, Miami, FL 33199, USA., Souchak J; Translational Glycobiology, Florida International University, Miami, FL 33199, USA., Ales E; Translational Glycobiology, Florida International University, Miami, FL 33199, USA., El-Hage N; Immunology and Nano-medicine, Florida International University, Miami, FL 33199, USA.
Publikováno v:
Toxicology reports [Toxicol Rep] 2022 Jun 16; Vol. 9, pp. 1357-1368. Date of Electronic Publication: 2022 Jun 16 (Print Publication: 2022).
Autor:
Zhang C; Department of Urology, The 940 Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, 730050, China., Kang Y; Department of Urology, The 940 Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, 730050, China., Kong F; Department of Urology, Beijing Fengtai Hospital of Integrated Traditional Chinese and Modern Medicine, Beijing, 100072, China., Yang Q; Department of Urology, The 940 Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, 730050, China., Chang D; Department of Urology, The 940 Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, 730050, China.
Publikováno v:
Non-coding RNA research [Noncoding RNA Res] 2022 Mar 21; Vol. 7 (2), pp. 77-88. Date of Electronic Publication: 2022 Mar 21 (Print Publication: 2022).