Výsledky vyhledávání - "FOXO3, Forkhead box O3"

Cytokine storm in the pathophysiology of COVID-19: Possible functional disturbances of miRNAs

Autor: Seyed Shahabeddin Mortazavi-Jahromi, Abbas Mirshafiey, Mona Aslani

Publikováno v: International Immunopharmacology

SARS-CoV-2, as the causative agent of COVID-19, is an enveloped positives-sense single-stranded RNA virus that belongs to the Beta-CoVs sub-family. A sophisticated hyper-inflammatory reaction named cytokine storm is occurred in patients with severe/c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4706f42d886bb679ed2a6b85453a9c
https://pubmed.ncbi.nlm.nih.gov/34601331

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Akademický článek

Key circRNAs from goat: discovery, integrated regulatory network and their putative roles in the differentiation of intramuscular adipocytes.

Autor: Yu, Du^1,2,3 (AUTHOR), Xin, Li^1,2,3 (AUTHOR), Qing, Xu^1,2,3 (AUTHOR), Hao, Zhang^1,2,3 (AUTHOR), Yong, Wang^1,2,3 (AUTHOR), Jiangjiang, Zhu^1,2 (AUTHOR), Yaqiu, Lin^1,2,3 (AUTHOR) linyq1999@163.com

Publikováno v: BMC Genomics. 1/28/2023, Vol. 24 Issue 1, p1-13. 13p.

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Akademický článek

CARM1 drives mitophagy and autophagy flux during fasting-induced skeletal muscle atrophy.

Autor: Stouth, Derek W., vanLieshout, Tiffany L., Mikhail, Andrew I., Ng, Sean Y., Raziee, Rozhin, Edgett, Brittany A., Vasam, Goutham, Webb, Erin K., Gilotra, Kevin S., Markou, Matthew, Pineda, Hannah C., Bettencourt-Mora, Brianna G., Noor, Haleema, Moll, Zachary, Bittner, Megan E., Gurd, Brendon J., Menzies, Keir J., Ljubicic, Vladimir

Publikováno v: Autophagy; Jun2024, Vol. 20 Issue 6, p1247-1269, 23p

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The local and circulating SOX9 as a potential biomarker for the diagnosis of primary bone cancer

Autor: Masoumeh Tavakoli-Yaraki, Vahid Salimi, Mostafa Ibrahimi, Zahra Rampisheh, Mehrdad Bahrabadi, Pegah Babaheidarian, Ameinh Hosseini, Fatemeh Hosami, Alireza Mirzaei, Zohreh Abdolvahabi, Khodamorad Jamshidi, Soudabeh Fallah, Narges Khademian

Publikováno v: Journal of Bone Oncology, Vol 23, Iss, Pp 100300-(2020)
Journal of Bone Oncology

Highlights • The SOX9 expression increased in tumor tissues and peripheral blood of malignant and benign bone tumors. • The protein level of SOX9 is enhanced in malignant bone tumor tissues. • SOX9 over-expression correlated with tumor severity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81383c3f75a7f37062761a0cf54f0a7
http://www.sciencedirect.com/science/article/pii/S2212137420300555

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Reciprocal regulation between GCN2 (eIF2AK4) and PERK (eIF2AK3) through the JNK-FOXO3 axis to modulate cancer drug resistance and clonal survival

Autor: Zimam Mahmud, Yannasittha Jiramongkol, Kitti Intuyod, Glowi Alasiri, Eric Lam, Huiling Ke, Sasanan Trakansuebkul

Publikováno v: Molecular and Cellular Endocrinology

Pharmaceutical inhibitors of the endoplasmic reticulum (ER)-stress modulator PERK (eIF2AK3) have demonstrated anticancer activities in combination therapies, but their effectiveness as a single agent is limited, suggesting the existence of possible c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1090678c396ca7581be72c83fc88f1e9
http://hdl.handle.net/10044/1/81106

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Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19

Autor: Tomal Dattaroy, Santanu Dasgupta, Vinod Nagle, Jayanta Talukdar, Bhaskar Bhadra

Publikováno v: Biomedicine & Pharmacotherapy, Vol 132, Iss, Pp 110886-(2020)
Biomedicine & Pharmacotherapy

Graphical abstract
Highlights • CS triggered by excessive inflammatory response drives the pathogenesis of COVID-19. • ASX inhibits TNFα, IL1β, IL6 via regulation of NF-kB & JAK/STAT; prevents CS & ALI/ARDS. • ASX suppresses plasma CRP,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd7bf3aa8d9fd5d6f23a47947a5470c
https://pubmed.ncbi.nlm.nih.gov/33113418

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Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction

Publikováno v: JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 385-400 (2019)

Visual Abstract
Highlights • MCD inhibition decreases fatty acid oxidation via increasing malonyl coenzyme A levels to prevent fatty acid uptake into mitochondria in the failing hearts induced by coronary artery ligation. • Downregulating fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074f5ff29e2376a91baabc9d38b612d8
https://pubmed.ncbi.nlm.nih.gov/31312761

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Circadian rhythms in liver metabolism and disease

Autor: John Y.L. Chiang, Jessica M. Ferrell

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 5, Iss 2, Pp 113-122 (2015)

Mounting research evidence demonstrates a significant negative impact of circadian disruption on human health. Shift work, chronic jet lag and sleep disturbances are associated with increased incidence of metabolic syndrome, and consequently result i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8694c3a420c6177ab77df19b950020b0
http://europepmc.org/articles/PMC4629216

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