Zobrazeno 1 - 10
of 25
pro vyhledávání: '"FOXO1, Forkhead box protein O1"'
Publikováno v:
Translational Oncology, Vol 16, Iss, Pp 101313-(2022)
Translational Oncology
Translational Oncology
Highlights • Co-inhibition of ERK1/2 and MCL-1 induces synergistic cell death in rhabdomyosarcoma. • Ulixertinib/S63845 co-treatment effectively induces caspase-dependent apoptosis. • BIM, BMF, BAK and BAX are required for Ulixertinib/S63845-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9f914981a207a50fa9cf51a7b0aef2
http://www.sciencedirect.com/science/article/pii/S1936523321003041
http://www.sciencedirect.com/science/article/pii/S1936523321003041
Autor:
Kirstein, A., Kehr, S., Nebe, M., Hanschkow, M., Barth, L., Lorenz, J., Penke, M., Breitfeld, J., Le Duc, D., https://orcid.org/0000-0001-7289-2552, Landgraf, K., Körner, A., Kovacs, P., Stadler, P., Kiess, W., Garten, A.
Publikováno v:
The Journal of Biological Chemistry
Journal of Biological Chemistry
Journal of Biological Chemistry
The tumor suppressor phosphatase and tensin homolog (PTEN) negatively regulates the insulin signaling pathway. Germline PTEN pathogenic variants cause PTEN hamartoma tumor syndrome (PHTS), associated with lipoma development in children. Adipose proge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ef7152ce7b26e3fa1186c680abb473b8
http://europepmc.org/articles/PMC8350019
http://europepmc.org/articles/PMC8350019
Publikováno v:
Biochimie Open, Vol 7, Iss, Pp 26-32 (2018)
Biochimie Open
Biochimie Open
Vanadate, a protein tyrosine phosphatase inhibitor which elicits insulin-like effects, has previously been shown to inhibit expression of the insulin receptor gene at the transcriptional level in rat hepatoma cells. In an attempt to identify the DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f28a98099c18d8f778c71445315c4d
https://doi.org/10.1016/j.biopen.2018.09.001
https://doi.org/10.1016/j.biopen.2018.09.001
Autor:
David L. Perrin, Ehsan Samiei, Mohammad Esmaeillou, Arya Emami, Saeid Ghavami, Mohsen Akbari, Joseph W. Gordon, Kiarash Roustai Geraylow, Mahboubeh Kavoosi, Evan Stefanek, Milad Ashrafizadeh
Publikováno v:
MethodsX, Vol 8, Iss, Pp 101473-(2021)
MethodsX
MethodsX
Rhabdomyosarcoma (RMS) is the most common pediatric soft-tissue malignant tumor. Treatment of RMS usually includes primary tumor resection along with systemic chemotherapy. Two-dimensional (2D) cell culture systems and animal models have been extensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a65b5f28456d93429faadea2d4109e
http://www.sciencedirect.com/science/article/pii/S2215016121002661
http://www.sciencedirect.com/science/article/pii/S2215016121002661
Autor:
Xiang, Ming, Liu, Tingting, Tian, Cheng, Ma, Kun, Gou, Jing, Huang, Rongrong, Li, Senlin, Li, Qing, Xu, Chuanrui, Li, Lei, Lee, Chih-Hao, Zhang, Yonghui
Publikováno v:
Pharmacological Research
Kinsenoside (KD) exhibits anti-inflammatory and immunosuppressive effects. Dendritic cells (DCs) are critical regulators of the pathologic inflammatory milieu in liver fibrosis (LF). Herein, we explored whether and how KD repressed development of LF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea3bc95005395ec64905cdfaef79c55
https://doi.org/10.1016/j.phrs.2022.106092
https://doi.org/10.1016/j.phrs.2022.106092
Autor:
Wenhao Ge, Xi Xu, Rui Cheng, Yunxia Yang, Yang Zhao, Dan Weng, Zhao Ding, Jianfa Zhang, Shiming Wang
Publikováno v:
The Journal of Biological Chemistry
Hepatic gluconeogenesis is the major contributor to the hyperglycemia observed in both patients and animals with type 2 diabetes. The transcription factor FOXO1 plays a dominant role in stimulating hepatic gluconeogenesis. FOXO1 is mainly regulated b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0a51a2b04d95fb5be0ca591b075400
https://doi.org/10.1016/j.jbc.2021.100846
https://doi.org/10.1016/j.jbc.2021.100846
Autor:
Kristin L. Ayers, Hongxia Ren, Matthew D. Hall, Min Shen, Hu Zhu, Jason M. Conley, Rong Chen, Hongmao Sun
Publikováno v:
The Journal of Biological Chemistry
GPR17 is a G-protein-coupled receptor (GPCR) implicated in the regulation of glucose metabolism and energy homeostasis. Such evidence is primarily drawn from mouse knockout studies and suggests GPR17 as a potential novel therapeutic target for the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b92d42d693b9ea9ec26925da8f44bb3
https://doi.org/10.1016/j.jbc.2021.100881
https://doi.org/10.1016/j.jbc.2021.100881
Publikováno v:
Redox Biology, Vol 12, Iss, Pp 82-102 (2017)
Redox Biology
Redox Biology
Metabolic diseases such as type 2 diabetes are a major public health issue worldwide. These diseases are often linked to a dysfunctional adipose tissue. Fat is a large, heterogenic, pleiotropic and rather complex tissue. It is found in virtually all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df746aedd2e3f16c2a5c1aa4babe2bd5
http://www.sciencedirect.com/science/article/pii/S2213231717300447
http://www.sciencedirect.com/science/article/pii/S2213231717300447
Autor:
Amalia Gastaldelli, Stefano Gatti, Miriam Longo, Stefano Romeo, Melania Gaggini, Paola Dongiovanni, Sara Badiali, Nicholas O. Davidson, Anna Ludovica Fracanzani, Guido Baselli, Serena Pelusi, Raffaela Rametta, Marica Meroni, Fabrizia Carli, Luca Valenti, Marco Maggioni
Publikováno v:
EBioMedicine
EBioMedicine, Vol 52, Iss, Pp-(2020)
EBioMedicine, Vol 52, Iss, Pp-(2020)
Background: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2796cd352ac1c041a84c02697c2c55d9
https://pubmed.ncbi.nlm.nih.gov/32058943
https://pubmed.ncbi.nlm.nih.gov/32058943
Autor:
Dmitry Akhmedov, Kavitha Rajendran, Nicholas J. Justice, Jingqi Fu, Mark Nixon, Rebecca Berdeaux, Randi Stewart-Fitzgibbon, Micah Gibson, Yisel A. Rivera-Molina, Maria G. Mendoza-Rodriguez, Eric D. Berglund
Publikováno v:
Molecular Metabolism, Vol 5, Iss 1, Pp 34-46 (2016)
Molecular Metabolism
Molecular Metabolism
Objective Insulin resistance causes type 2 diabetes mellitus and hyperglycemia due to excessive hepatic glucose production and inadequate peripheral glucose uptake. Our objectives were to test the hypothesis that the proposed CREB/CRTC2 inhibitor sal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0277d54dcde91a95c0ba4c58a9f35e6
https://doi.org/10.1016/j.molmet.2015.10.004
https://doi.org/10.1016/j.molmet.2015.10.004