Výsledky vyhledávání - "FN, fibronectin"

Fibronectin-coating enhances attachment and proliferation of mesenchymal stem cells on a polyurethane meniscal scaffold

Autor: Arredondo, Raquel, Poggioli, Francesco, Martínez-Díaz, Santos, Piera-Trilla, María, Torres-Claramunt, Raúl, Tío Barrera, Laura, Monllau García, Joan Carles, Universitat Autònoma de Barcelona

Publikováno v: Regenerative Therapy, Vol 18, Iss, Pp 480-486 (2021)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Regenerative Therapy

Introduction Partial meniscectomy is one of the most common surgical strategy for a meniscal injury, but sometimes, patients complain of knee pain due to an overload in the ablated compartment. In these cases, implantation of tissue engineering scaff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bddc156aff7f65912886eb5d196c0c
https://doi.org/10.1016/j.reth.2021.11.001

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Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

Autor: Hai-Yong Chen, Yibin Feng, Cheng Zhang, Ning Wang, Sha Li, Guoyi Tang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)

Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020

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Proteomic Architecture of Valvular Extracellular Matrix

Autor: Anelechi C. Anyanwu, Justin Snider, Paul Stelzer, Sandra Guauque-Olarte, Djamel Lebeche, Devyn Zaminski, Rihab Bouchareb

Publikováno v: JACC: Basic to Translational Science

Visual Abstract
Highlights • ECM proteins play an important role in maintaining the structural architecture and the mechanical behavior of the aortic valve. • Network analysis highlights a strong connection between metabolic markers and ECM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358a76cc202c948f2333967b792348b8
http://europepmc.org/articles/PMC7838057

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The potential role of sesquiterpene lactones isolated from medicinal plants in the treatment of the metabolic syndrome – A review

Autor: Anuar Salazar-Gómez, Saudy Saret Pablo-Pérez, M. Elena Vargas-Dı́az, Julio C. Ontiveros-Rodríguez, Leticia Garduño-Siciliano

Publikováno v: South African Journal of Botany

Highlights • Definition and pathogenesis of metabolic syndrome is briefly described. • Sesquiterpene lactones isolated from medicinal plants used in traditional medicine. • In vivo and in vitro biological activities of sesquiterpene lactones ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512583e8aceec7a8d3995bc13c6d8a6c
https://doi.org/10.1016/j.sajb.2020.08.020

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Extracellular vesicle-orchestrated crosstalk between cancer-associated fibroblasts and tumors

Autor: Guiquan Zhu, Chuanshi He, Linlin Wang, Ling Li

Publikováno v: Translational Oncology, Vol 14, Iss 12, Pp 101231-(2021)
Translational Oncology

Highlights • EVs mediate the interaction between tumor and stromal cells in the TME. • Tumors mediate CAF-like activation of stromal cells through EVs. • CAF-derived EVs promote tumor proliferation, metastasis and therapeutic resistance.
C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5dbb220f9849b850d3378d75eced1b
http://www.sciencedirect.com/science/article/pii/S1936523321002230

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The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation

Autor: Leandro Moretti, Jack Stalfort, Thomas Harrison Barker, Daniel Abebayehu

Publikováno v: The Journal of Biological Chemistry

Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of deaths across the world. Since the discovery of scarless functional healing in fetuses prior to a certain stage of development, scientists have attempted to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4b6370ffc1bac30359b2b701f66701
https://pubmed.ncbi.nlm.nih.gov/34953859

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Heparan sulfate is necessary for the early formation of nascent fibronectin and collagen I fibrils at matrix assembly sites

Autor: Katherine E. Hill, Benjamin M. Lovett, Jean E. Schwarzbauer

Publikováno v: The Journal of Biological Chemistry

Fibronectin (FN), an essential component of the extracellular matrix (ECM), is assembled via a cell-mediated process in which integrin receptors bind secreted FN and mediate its polymerization into fibrils that extend between cells, ultimately formin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a814e97b6c25bd5dfe573021712f6e7
http://europepmc.org/articles/PMC8801470

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Effect of dihydromyricetin on SARS-CoV-2 viral replication and pulmonary inflammation and fibrosis

Autor: Mingjiang Li, Shanfa Ren, Dongmei Li, Ming Wang, Xiaohe Li, Liang Zhang, Ting Xiao, Hao Ruan, Ronghao Sun, Dandi Gao, Honggang Zhou, Cheng Yang, Jianping Lin, Jiali Bao, Yuli Wei, Mengqi Cui

Publikováno v: Phytomedicine

Background COVID-19 (Coronavirus Disease-2019) has spread widely around the world and impacted human health for millions. The lack of effective targeted drugs and vaccines forces scientific world to search for new effective antiviral therapeutic drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1eaa515f7bb1f76cca7927250b730e
https://pubmed.ncbi.nlm.nih.gov/34419736

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A review for natural polysaccharides with anti-pulmonary fibrosis properties, which may benefit to patients infected by 2019-nCoV

Autor: Ya-jun Li, Jun-jia Chen, Ruirong Chen, Chuan-li Lu

Publikováno v: Carbohydrate Polymers

Graphical abstract
Highlights • Pulmonary fibrosis is high probably a major complication in COVID-19 patients. • 16 kinds of polysaccharides possess significant anti-pulmonary fibrosis activities. • TGF-β is an important target for anti-p

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Elevated glucose alters global gene expression and tenascin-C alternative splicing in mesangial cells

Autor: Maria E. Vega, John B. Finlay, Jean E. Schwarzbauer, Mansi Vasishtha

Publikováno v: Matrix Biology Plus, Vol 8, Iss, Pp 100048-(2020)
Matrix Biology Plus

Mesangial cells are the major extracellular matrix (ECM)-producing cells in the kidney glomerulus and, when exposed to elevated glucose levels, they up-regulate assembly of fibronectin (FN) and other ECM proteins. Increases in glucose concentration a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5718ea02ef58c8ee77dcb749a2b6d55
http://www.sciencedirect.com/science/article/pii/S2590028520300296

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