Zobrazeno 1 - 10
of 2 198
pro vyhledávání: '"FMRP"'
Autor:
Navneeta Kaul, Sarala J. Pradhan, Nathan G. Boin, Madeleine M. Mason, Julian Rosales, Emily L. Starke, Emily C. Wilkinson, Erich G. Chapman, Scott A. Barbee
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 11-22 (2024)
Fragile X Syndrome (FXS) is the most common inherited form of intellectual disability and is caused by mutations in the gene encoding the Fragile X messenger ribonucleoprotein (FMRP). FMRP is an evolutionarily conserved and neuronally enriched RNA-bi
Externí odkaz:
https://doaj.org/article/2ceefdce3e2846ea83bca36538c1d3c1
Autor:
Nan Wang, Bin Shi, Lu Ding, Xu Zhang, Xiaolan Ma, Songlin Guo, Xia Qiao, Libin Wang, Duan Ma, Jia Cao
Publikováno v:
Redox Biology, Vol 77, Iss , Pp 103382- (2024)
Ferroptosis is a unique modality of regulated cell death that is driven by iron-dependent phospholipid peroxidation. N6-methyladenosine (m6A) RNA modification participates in varieties of cellular processes. However, it remains elusive whether m6A re
Externí odkaz:
https://doaj.org/article/9834eacbe4134b7481dda70b23df99a2
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Ubiquitination is one of the most conserved post-translational modifications and together with mRNA translation contributes to cellular protein homeostasis (proteostasis). Temporal and spatial regulation of proteostasis is particularly important duri
Externí odkaz:
https://doaj.org/article/5aadd2d0f24f447b94e256b494448f4f
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Vipendra Kumar, Kwan Young Lee, Anirudh Acharya, Matthew S Babik, Catherine A Christian-Hinman, Justin S Rhodes, Nien-Pei Tsai
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 506-522 (2024)
Abstract Fragile X syndrome (FXS) is the leading cause of inherited autism and intellectual disabilities. Aberrant protein synthesis due to the loss of fragile X messenger ribonucleoprotein (FMRP) is the major defect in FXS, leading to a plethora of
Externí odkaz:
https://doaj.org/article/b326dbbf75824151a5fca593719224e0
Autor:
Xuan Phuoc Nguyen, Adriana Vilkaite, Ulrike Bender, Jens E. Dietrich, Katrin Hinderhofer, Thomas Strowitzki, Julia Rehnitz
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10643 (2024)
Fragile X mental retardation protein (FMRP) is a translational repressor encoded by FMR1. It targets bone morphogenetic protein receptor type II (BMPR2), which regulates granulosa cell (GC) function and follicle development. However, whether this int
Externí odkaz:
https://doaj.org/article/f92821bf21244fe3b8aa8a7af5beb2e2
Proteomics insights into fragile X syndrome: Unraveling molecular mechanisms and therapeutic avenues
Publikováno v:
Neurobiology of Disease, Vol 194, Iss , Pp 106486- (2024)
Fragile X Syndrome (FXS) is a neurodevelopment disorder characterized by cognitive impairment, behavioral challenges, and synaptic abnormalities, with a genetic basis linked to a mutation in the FMR1 (Fragile X Messenger Ribonucleoprotein 1) gene tha
Externí odkaz:
https://doaj.org/article/bd4c2ff882ad436e9388c5261b14161c
Autor:
Salima Messaoudi, Ada Allam, Julie Stoufflet, Theo Paillard, Anaïs Le Ven, Coralie Fouquet, Mohamed Doulazmi, Alain Trembleau, Isabelle Caille
Publikováno v:
eLife, Vol 12 (2024)
The fragile X syndrome (FXS) represents the most prevalent form of inherited intellectual disability and is the first monogenic cause of autism spectrum disorder. FXS results from the absence of the RNA-binding protein FMRP (fragile X messenger ribon
Externí odkaz:
https://doaj.org/article/13fa9b263153445990b54ed25e7201d9
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-8 (2023)
Abstract FMRP, an RNA-binding protein, has previously shown to be involved in regulation of circadian rhythms in flies and mice. However, the molecular mechanism remains elusive. Here we demonstrate that core circadian component Per1 mRNA was a targe
Externí odkaz:
https://doaj.org/article/96855a94a21c4e92b9d324644ba27b94
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 399 (2024)
Silencing of the fragile X messenger ribonucleoprotein 1 (FMR1) gene and a consequent lack of FMR protein (FMRP) synthesis are associated with fragile X syndrome, one of the most common inherited intellectual disabilities. FMRP is a multifunctional p
Externí odkaz:
https://doaj.org/article/4399184af015477eaba18d5baf156e91