2-fluoro-1-methylpyridinium p-toluene sulfonate: a new LC-MS/MS derivatization reagent for vitamin D metabolites

Autor: Anastasia Alexandridou, Dietrich A. Volmer

Publikováno v: Journal of Lipid Research, Vol 64, Iss 8, Pp 100409- (2023)

Vitamin D analysis by MS faces several analytical challenges, including inefficient ionization, nonspecific fragmentation, interferences from epimers, isomers, and isobars, as well as very low concentration levels. In this study, we used 2-fluoro-1-m

Externí odkaz: https://doaj.org/article/a4cad688576443d3a3d9d65bbcd1d040

Derivatization of estrogens enhances specificity and sensitivity of analysis of human plasma and serum by liquid chromatography tandem mass spectrometry

Autor: Faqehi, Abdullah M.M., Cobice, Diego F., Naredo, Gregorio, Mak, Tracy C.S., Upreti, Rita, Gibb, Fraser W., Beckett, Geoffrey J., Walker, Brian R., Homer, Natalie Z.M., Andrew, Ruth

Publikováno v: Faqehi, A M, Cobice, D F, Naredo, G, Mak, T C, Upreti, R, Gibb, F W, Beckett, G J, Walker, B R, Homer, N Z M & Andrew, R 2016, ' Derivatization of estrogens enhances specificity and sensitivity of analysis of human plasma and serum by liquid chromatography tandem mass spectrometry ', Talanta, vol. 151, pp. 148–156 . https://doi.org/10.1016/j.talanta.2015.12.062
Talanta

Estrogens circulate at concentrations less than 20 pg/mL in men and postmenopausal women, presenting analytical challenges. Quantitation by immunoassay is unreliable at these low concentrations. Liquid chromatography tandem mass spectrometry (LC–MS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::aef06375c6cdf233b6b9a509f2a2f89c