Výsledky vyhledávání - "FMN, flavin mononucleotide"

Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis

Autor: Tiantian Qi, Letian Zhang, Tingyuan Yang, Yating Luo, Shiliang Li, Fanxun Zeng, Lili Zhu, Guantian Yang, Yingfan Liang, Honglin Li, Rui Wang, Xiaoyong Xu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 795-809 (2021)
Acta Pharmaceutica Sinica. B

Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS). Herein, a series of acrylamide-bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe3ff9d9c75c7a612636b452a341e1f
http://www.sciencedirect.com/science/article/pii/S2211383520307590

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The minimal structure for iodotyrosine deiodinase function is defined by an outlier protein from the thermophilic bacterium Thermotoga neapolitana

Autor: Shaun Spisak, Steven E. Rokita, Bing Xu, Jennifer M. Kavran, Zuodong Sun

Publikováno v: The Journal of Biological Chemistry

The nitroreductase superfamily of enzymes encompasses many flavin mononucleotide (FMN)-dependent catalysts promoting a wide range of reactions. All share a common core consisting of an FMN-binding domain, and individual subgroups additionally contain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be79555d175b00f23fd0c65fac08e16c
https://pubmed.ncbi.nlm.nih.gov/34748729

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The Microbial Toxin Microcin B17: Prospects for the Development of New Antibacterial Agents

Autor: Frédéric Collin, Anthony Maxwell

Publikováno v: Journal of Molecular Biology

Microcin B17 (MccB17) is an antibacterial peptide produced by strains of Escherichia coli harboring the plasmid-borne mccB17 operon. MccB17 possesses many notable features. It is able to stabilize the transient DNA gyrase–DNA cleavage complex, a ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4884b56a10e856bc068728857dc94b
http://europepmc.org/articles/PMC6722960

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The molecular basis of spectral tuning in blue- and red-shifted flavin-binding fluorescent proteins

Autor: Ulrich Krauss, Katrin Röllen, Kirill Kovalev, Joachim Granzin, Vera V. Nazarenko, Valentin Borshchevskiy, Valentin Gordeliy, Andrey Bogorodskiy, Ulrich Schwaneberg, Ivan Gushchin, Karl-Erich Jaeger, Alina Remeeva, Renu Batra-Safferling, Thomas Gensch, Stefanie Hemmer, Mehdi D. Davari

Publikováno v: The journal of biological chemistry 296, 100662 (2021). doi:10.1016/j.jbc.2021.100662
The Journal of Biological Chemistry
'Journal of Biological Chemistry ', vol: 296, pages: 100662-1-100662-13 (2021)
The journal of biological chemistry : JBC 296, 100662 (2021). doi:10.1016/j.jbc.2021.100662
The journal of biological chemistry 296, 100662-(2021). doi:10.1016/j.jbc.2021.100662

The journal of biological chemistry 296, 100662 (2021). doi:10.1016/j.jbc.2021.100662
Photoactive biological systems modify the optical properties of their chromophores, known as spectral tuning. Determining the molecular origin of spectral tuni

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Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury

Autor: Sarah A. Hosgood, Kourosh Saeb-Parsy, Michael P. Murphy, Michael L. Nicholson, Hiran A. Prag, Timothy E. Beach, Anja V. Gruszczyk, Krishnaa T. Mahbubani, Margaret M. Huang, Richard C. Hartley, Mazin Hamed, Jack Martin, Laura Pala, Andrew M. James, Angela Logan

Publikováno v: Redox Biology
Redox Biology, Vol 36, Iss, Pp 101640-(2020)

Renal ischemia reperfusion (IR) injury leads to significant patient morbidity and mortality, and its amelioration is an urgent unmet clinical need. Succinate accumulates during ischemia and its oxidation by the mitochondrial enzyme succinate dehydrog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a428db7cbb67317a1cf4d229c00bb9
http://europepmc.org/articles/PMC7372157

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Bacterial riboswitches and RNA thermometers: Nature and contributions to pathogenesis

Autor: Jameel M.A. Abduljalil

Publikováno v: Non-coding RNA Research, Vol 3, Iss 2, Pp 54-63 (2018)
Non-coding RNA Research

Bacterial pathogens are always challenged by fluctuations of chemical and physical parameters that pose serious threats to cellular integrity and metabolic status. Sudden deprivation of nutrients or key metabolites, changes in surrounding pH, and tem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06114bb05c81bf86dc0542ab3e0bf2bc
http://www.sciencedirect.com/science/article/pii/S2468054018300118

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gRASping the redox lever to modulate cancer cell fate signaling

Autor: Chuan Han Jonathan Foo, Shazib Pervaiz

Publikováno v: Redox Biology, Vol 25, Iss, Pp-(2019)
Redox Biology

RAS proteins are critical regulators of signaling networks controlling diverse cellular functions such as cell proliferation and survival and its mutation are among the most powerful oncogenic drivers in human cancers. Despite intense efforts, direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11cd3c78529b5f4eae7369f41a3e411
http://www.sciencedirect.com/science/article/pii/S2213231718311558

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Lighting the way: Recent insights into the structure and regulation of phototropin blue light receptors

Autor: Jaynee E. Hart, Kevin H. Gardner

Publikováno v: The Journal of Biological Chemistry

The phototropins (phots) are light-activated kinases that are critical for plant physiology and the many diverse optogenetic tools that they have inspired. Phototropins combine two blue-light-sensing Light–Oxygen–Voltage (LOV) domains (LOV1 and L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8859556c73edb8874b6f8afc4ea5117
https://doi.org/10.1016/j.jbc.2021.100594

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Large-Scale Analysis Exploring Evolution of Catalytic Machineries and Mechanisms in Enzyme Superfamilies

Autor: Janet M. Thornton, Natalie L. Dawson, Christine A. Orengo, Nicholas Furnham, Syed Asad Rahman

Publikováno v: Journal of Molecular Biology

Enzymes, as biological catalysts, form the basis of all forms of life. How these proteins have evolved their functions remains a fundamental question in biology. Over 100 years of detailed biochemistry studies, combined with the large volumes of sequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64bd40611d407deefb2be82cde7c1da0
http://europepmc.org/articles/PMC4751976

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Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation

Autor: Philipp Kron, Matteo Mueller, Olivier de Rougemont, David Meierhofer, Philipp Dutkowski, Paolo Muiesan, Anna Stepanova, Xavier Muller, Andrea Schlegel, Alexander Galkin, Pierre-Alain Clavien

Publikováno v: EBioMedicine
EBioMedicine, Vol 60, Iss, Pp 103014-(2020)

Background Mitochondrial succinate accumulation has been suggested as key event for ischemia reperfusion injury in mice. No specific data are however available on behavior of liver mitochondria during ex situ machine perfusion in clinical transplant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b9e911eda3c09d19bbb520f7b49a76
https://doi.org/10.1016/j.ebiom.2020.103014

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