FLT3‐targeted therapy restores GATA1 pathway function in NPM1/FLT3‐ITD mutated acute myeloid leukaemia

Autor: D Sorcini, A Stella, A Scialdone, S Sartori, A Marra, R Rossi, F De Falco, FM Adamo, E Dorillo, C Geraci, R Arcaleni, C Rompietti, A Esposito, L Moretti, MG Mameli, MP Martelli, B Falini, P Sportoletti

Publikováno v: eJHaem, Vol 4, Iss 4, Pp 1100-1104 (2023)

Abstract One‐third of newly diagnosed adult acute myeloid leukaemia (AML) carry FLT3 mutations, which frequently occur together with nucleophosmin (NPM1) mutations and are associated with worse prognosis. FLT3 inhibitors are widely used in clinics

Externí odkaz: https://doaj.org/article/4c38b29289274a7990c345b01979a9de

NOTCH1 -mutated chronic lymphocytic leukemia displays high endoplasmic reticulum stress response with druggable potential.

Autor: Silva Barcelos EC; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy.; Postgraduate Program in Biotechnology, Federal University of Espírito Santo, Vitória, Brazil., Rompietti C; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Adamo FM; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Dorillo E; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., De Falco F; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Del Papa B; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Baldoni S; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy.; Department of Medicine and Sciences of Aging, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy., Nogarotto M; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Esposito A; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Capoccia S; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Geraci C; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Sorcini D; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Stella A; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Arcaleni R; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Tini V; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Imbroisi Valle Errera F; Postgraduate Program in Biotechnology, Federal University of Espírito Santo, Vitória, Brazil., Rosati E; Department of Medicine and Surgery, Biosciences and Medical Embryology Section, University of Perugia, Perugia, Italy., Sportoletti P; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy.

Publikováno v: Frontiers in oncology [Front Oncol] 2023 Sep 25; Vol. 13, pp. 1218989. Date of Electronic Publication: 2023 Sep 25 (Print Publication: 2023).

Therapeutic Targeting Potential of Novel Silver Nanoparticles Coated with Anti-CD20 Antibody against Chronic Lymphocytic Leukemia.

Autor: Adamo FM; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06129 Perugia, Italy., Silva Barcelos EC; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06129 Perugia, Italy.; Postgraduate Program in Biotechnology, Federal University of Espírito Santo, Vitória 29043-900, Brazil., De Falco F; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06129 Perugia, Italy., Dorillo E; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06129 Perugia, Italy., Rompietti C; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06129 Perugia, Italy., Sorcini D; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06129 Perugia, Italy., Stella A; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06129 Perugia, Italy., Del Papa B; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06129 Perugia, Italy., Baldoni S; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06129 Perugia, Italy.; Department of Medicine and Sciences of Aging, 'G. d'Annunzio' University of Chieti-Pescara, 66100 Chieti, Italy., Esposito A; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06129 Perugia, Italy., Geraci C; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06129 Perugia, Italy., Arcaleni R; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06129 Perugia, Italy., Pennetta C; Department of Chemistry, Biology and Biotechnologies, University of Perugia, 06123 Perugia, Italy., Ragonese F; Department of Chemistry, Biology and Biotechnologies, University of Perugia, 06123 Perugia, Italy., Moretti L; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06129 Perugia, Italy., Mameli M; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06129 Perugia, Italy., Di Ianni M; Department of Medicine and Sciences of Aging, 'G. d'Annunzio' University of Chieti-Pescara, 66100 Chieti, Italy., Rosati E; Department of Medicine and Surgery, Biosciences and Medical Embryology Section, University of Perugia, 06129 Perugia, Italy., Fioretti B; Department of Chemistry, Biology and Biotechnologies, University of Perugia, 06123 Perugia, Italy., Sportoletti P; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06129 Perugia, Italy.

Publikováno v: Cancers [Cancers (Basel)] 2023 Jul 14; Vol. 15 (14). Date of Electronic Publication: 2023 Jul 14.

GSK3β is a critical, druggable component of the network regulating the active NOTCH1 protein and cell viability in CLL.

Autor: De Falco F; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Rompietti C; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Sorcini D; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Esposito A; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Scialdone A; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Baldoni S; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy.; Department of Medicine and Sciences of Aging, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy., Del Papa B; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Adamo FM; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Silva Barcelos EC; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Dorillo E; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Stella A; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy., Di Ianni M; Department of Medicine and Sciences of Aging, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy.; Department of Oncology and Hematology, Ospedale Civile 'Santo Spirito', ASL Pescara, Pescara, Italy., Screpanti I; Department of Molecular Medicine, University of Rome 'La Sapienza', Rome, Italy., Sportoletti P; Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy. paolo.sportoletti@unipg.it., Rosati E; Department of Medicine and Surgery, University of Perugia, Perugia, Italy. emanuela.rosati@unipg.it.

Publikováno v: Cell death & disease [Cell Death Dis] 2022 Sep 01; Vol. 13 (9), pp. 755. Date of Electronic Publication: 2022 Sep 01.

Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice.

Autor: Sportoletti P; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy. paolo.sportoletti@unipg.it., Sorcini D; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy., Guzman AG; Stem Cell and Regenerative Medicine, Baylor College of Medicine, Houston, TX, 77030, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital and Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, 77030, USA., Reyes JM; Stem Cell and Regenerative Medicine, Baylor College of Medicine, Houston, TX, 77030, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital and Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, 77030, USA., Stella A; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy., Marra A; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy., Sartori S; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy., Brunetti L; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy., Rossi R; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy., Papa BD; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy., Adamo FM; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy., Pianigiani G; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy., Betti C; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy., Scialdone A; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy., Guarente V; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy., Spinozzi G; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy., Tini V; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy., Martelli MP; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy., Goodell MA; Stem Cell and Regenerative Medicine, Baylor College of Medicine, Houston, TX, 77030, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital and Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, 77030, USA., Falini B; Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, 06132, Italy. brunangelo.falini@unipg.it.

Publikováno v: Leukemia [Leukemia] 2021 Jul; Vol. 35 (7), pp. 1949-1963. Date of Electronic Publication: 2020 Nov 06.