Zobrazeno 1 - 10
of 398
pro vyhledávání: '"FLT3 inhibitors"'
Autor:
Monica Messina, Alfonso Piciocchi, Leonardo M. Siena, Stefano Soddu, Francesco Buccisano, Cristina Mecucci, Giovanni Martinelli, Antonio Curti, Roberto Cairoli, Paola Fazi, Marco Vignetti, Maria Teresa Voso, Adriano Venditti, Anna Candoni
Publikováno v:
eJHaem, Vol 5, Iss 6, Pp 1274-1277 (2024)
Abstract Given the limited data on the real‐life therapeutic use of feline McDonough sarcoma (FMS)‐like tyrosine kinase 3 (FLT3) inhibitors in Italy, we surveyed investigators at 59 Italian hematology centers to gain insight into the proportion o
Externí odkaz:
https://doaj.org/article/2fe19f632fcc4e089bc8f256326dab04
Akademický článek
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Autor:
D Sorcini, A Stella, A Scialdone, S Sartori, A Marra, R Rossi, F De Falco, FM Adamo, E Dorillo, C Geraci, R Arcaleni, C Rompietti, A Esposito, L Moretti, MG Mameli, MP Martelli, B Falini, P Sportoletti
Publikováno v:
eJHaem, Vol 4, Iss 4, Pp 1100-1104 (2023)
Abstract One‐third of newly diagnosed adult acute myeloid leukaemia (AML) carry FLT3 mutations, which frequently occur together with nucleophosmin (NPM1) mutations and are associated with worse prognosis. FLT3 inhibitors are widely used in clinics
Externí odkaz:
https://doaj.org/article/4c38b29289274a7990c345b01979a9de
Publikováno v:
BMC Chemistry, Vol 17, Iss 1, Pp 1-31 (2023)
Abstract Fms-like tyrosine kinase 3 (FLT3) mutation mechanisms are among the most common genetic abnormalities detected in about 30% of acute myeloid leukemia (AML) patients. These mutations are accompanied by poor clinical response, although all the
Externí odkaz:
https://doaj.org/article/2b723de9318e4bd5922bddc9cc3dd5f8
Autor:
Natsuki Hirose, Takayoshi Tachibana, Akihiko Izumi, Shuku Sato, Noriyuki Tadera, Yotaro Tamai, Heiwa Kanamori, Masatsugu Tanaka, Hideaki Nakajima
Publikováno v:
Hematology, Vol 28, Iss 1 (2023)
ABSTRACTObjectives and Methods This single-center retrospective study was performed to evaluate the safety and efficacy of FMS-like tyrosine kinase 3 (FLT3) inhibitors before and after allogeneic hematopoietic cell transplantation (HCT) in relapsed/r
Externí odkaz:
https://doaj.org/article/f91cf94c75a84c5eb87d94b67595d990
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
CPX-351, a dual-drug liposomal encapsulation of daunorubicin and cytarabine in a 1:5 molar ratio, is approved for the treatment of newly diagnosed therapy-related acute myeloid leukemia (AML) or AML with myelodysplasia-related changes. In a pivotal p
Externí odkaz:
https://doaj.org/article/1cda4855cb34403eb6a598e66a41608c
Autor:
Mahesh Swaminathan, Mai M. Aly, Abdul Moiz Khan, Bayan Al Share, Vikram Dhillon, Enxhi Lalo, Harry Ramos, Katherine G. Akers, Seongho Kim, Suresh Balasubramanian
Publikováno v:
eJHaem, Vol 4, Iss 1, Pp 165-173 (2023)
Abstract Several FLT3 inhibitors(i) are available to treat relapsed/refractory (R/R) FLT3‐internal tandem duplicated acute myeloid leukemia (AML). This study analyzes the efficacies of various FLT3i (types 1 and 2) tested in clinical trials in trea
Externí odkaz:
https://doaj.org/article/b7c23a0461fe4c168747b376b89b966f
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
Christian Récher
Publikováno v:
eJHaem, Vol 2, Iss 4, Pp 823-833 (2021)
Abstract In the field of AML, the early 2000s were shaped by the advent of novel molecular biology technologies including high‐throughput sequencing that improved prognostic classification, response evaluation through the quantification of minimal
Externí odkaz:
https://doaj.org/article/ae0da44567f84bcd949c634bffe9d538
Publikováno v:
Engineering, Vol 7, Iss 10, Pp 1354-1368 (2021)
Modern therapy of acute myeloid leukemia (AML) began in 1973 with the first report of the successful combination of daunorubicin and cytarabine, which led to complete remission in approximately 45% of patients. Accurate AML diagnosis was dependent on
Externí odkaz:
https://doaj.org/article/c205abd2e89c47dfaae5a43c89827b2a