Zobrazeno 1 - 10
of 56
pro vyhledávání: '"FLT3/ITD Mutation"'
Publikováno v:
Pakistan Armed Forces Medical Journal, Vol 73, Iss 6 (2023)
Objective: To assess the frequency of FLT3/ITD mutation in patients of Acute myeloid leukaemia presenting at Combined Military Hospital, Rawalpindi Pakistan. Study Design: Cross-sectional study. Place and Duration of Study: Oncology Department, C
Externí odkaz:
https://doaj.org/article/9c5e0334ffb5486eb89c9cb3d2b047c0
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 45, Iss 1, Pp 77-82 (2023)
Introduction: Acute myeloid leukemia (AML) is a heterogeneous disease and approximately one-third of its carriers do not have evident genetic abnormalities. The mutation of specific molecular markers, such as fms-like tyrosine kinase 3 (FTL3) interna
Externí odkaz:
https://doaj.org/article/fa56c1149b964133bd9b96d46d247d4b
Akademický článek
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Publikováno v:
Blood Science, Vol 3, Iss 4, Pp 132-135 (2021)
In general, acute myeloid leukemia (AML) is an aggressive and heterogeneous disease that is characterized by rapid cellular proliferation and high mortality. One of the mutations related to AML is the Flt3-ITD mutation, which is found in approximatel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e82656bee1bdc1a5e816b21bf8db8c
http://journals.lww.com/10.1097/BS9.0000000000000092
http://journals.lww.com/10.1097/BS9.0000000000000092
Autor:
Anna Kopińska, Grzegorz Helbig, Agnieszka Karolczyk, Krzysztof Woźniczka, Iwona Grygoruk-Wiśniowska, Małgorzata Stachowicz, Anna Koclęga, Kinga Boral, Agata Wieczorkiewicz-Kabut
Publikováno v:
Annals of Hematology
Acute myeloid leukemia (AML) with fetal liver tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) is associated with poor prognosis, and allogeneic stem cell transplantation (Allo-SCT) seems to be the preferred therapeutic approach. However, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72935b0bbf354412e044e1f83917417b
https://doi.org/10.1007/s00277-020-04026-1
https://doi.org/10.1007/s00277-020-04026-1
Publikováno v:
médecine/sciences. 37:544-546
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::914155c51c3b0877e88e4eb5929059aa
https://doi.org/10.1051/medsci/2021048
https://doi.org/10.1051/medsci/2021048
Akademický článek
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Autor:
Regina Rumpel, Steven R. Talbot, Zhixiong Li, Oliver Dittrich-Breiholz, Min Yang, Gudrun Göhring, Guntram Büsche, Jianfeng Zhou, Karl Welte, Hongyun Liu, Zengkai Pan, Arnold Ganser, Ligen Liu, Kezhi Huang, Michaela Scherr, Nils von Neuhoff, Julia Skokowa, Matthias Eder, Anuhar Chaturvedi
With an incidence of ~50%, the absence or reduced protein level of p53 is much more common than TP53 mutations in acute myeloid leukemia (AML). AML with FLT3-ITD (internal tandem duplication) mutations has an unfavorable prognosis and is highly assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d6cd959127b78f5a3b0d69c4d402f2
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85118685466
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85118685466
Autor:
Xuejie Jiang, Changfen Huang, Qiang Wang, Yishan Chen, Zhao Yin, Guopan Yu, Ying Yang, Qifa Liu, Dan Xu, Changxin Yin, Ling Jiang
Background: Autophagy plays a critical role in drug resistance in acute myeloid leukemia (AML), including the subtype with FLT3-ITD mutation. Yet how autophagy is activated and mediates resistance to FLT3 inhibitors in FLT3-ITD-positive AML remains u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9085e67f28a3673949a08130b4ea75c0
https://doi.org/10.21203/rs.3.rs-676343/v1
https://doi.org/10.21203/rs.3.rs-676343/v1
Autor:
Thomas Schroeder, Anna Dolnik, Arnold Ganser, Frauke Theis, Peter Paschka, Gerald Wulf, Laura K. Schmalbrock, Saverio Minucci, Lars Bullinger, Clara D. Bloomfield, Eric Sträng, Walter Fiedler, Ekaterina Panina, Konstanze Döhner, Michael Heuser, Hendrik G. Stunnenberg, Tamara J. Blätte, Sibylle Cocciardi, Hartmut Döhner, Richard F. Schlenk, Michael Lübbert, Helmut R. Salih, Richard Stone, Verena I. Gaidzik, Sabrina Skambraks, Nikolaus Jahn, Richard A. Larson, Julia Herzig, Felicitas Thol, Frank G. Rücker
Publikováno v:
Blood, 137, 22, pp. 3093-3104
Blood, 137, 3093-3104
BASE-Bielefeld Academic Search Engine
Blood, 137, 3093-3104
BASE-Bielefeld Academic Search Engine
In the international randomized phase 3 RATIFY (Randomized AML Trial In FLT3 in patients less than 60 Years old) trial, the multikinase inhibitor midostaurin significantly improved overall and event-free survival in patients 18 to 59 years of age wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c19bfa45cba1916b3fabac1ff4606eb
https://repository.ubn.ru.nl/handle/2066/240253
https://repository.ubn.ru.nl/handle/2066/240253