Zobrazeno 1 - 10
of 249
pro vyhledávání: '"FLT-3"'
Publikováno v:
International Journal of Hematology-Oncology and Stem Cell Research, Vol 17, Iss 3 (2023)
Background: The identification of long non-coding RNAs (lncRNAs) in the pathogenesis of acute myeloid leukemia (AML) has marked a new era in the molecular understating of the disease. This study investigated the correlation between the changes in the
Externí odkaz:
https://doaj.org/article/6ca22749fce04f57a95f91f8c5cc5696
Autor:
Maria Zulfiqar, Natasha Ali, Usman Shaikh, Hamzah Jehanzeb, Salman Arif, Zurrya Fasih Khan, Nabiha Saeed, Zeeshan Ansar
Publikováno v:
Journal of Cancer and Allied Specialties, Vol 9, Iss 2 (2023)
Introduction: Molecular genetic abnormalities in AML are essential for disease diagnosis and determining prognosis and clinical course. Mutations in FLT3 and NPM genes are the most frequent genetic abnormalities, which are also known to impact diseas
Externí odkaz:
https://doaj.org/article/65da7085675e418ea8e82f622013899d
Autor:
Seong Hun Jang, Dakshinamurthy Sivakumar, Sathish Kumar Mudedla, Jaehan Choi, Sungmin Lee, Minjun Jeon, Suneel Kumar Bvs, Jinha Hwang, Minsung Kang, Eun Gyeong Shin, Kyu Myung Lee, Kwan-Young Jung, Jae-Sung Kim, Sangwook Wu
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Treating acute myeloid leukemia (AML) by targeting FMS-like tyrosine kinase 3 (FLT-3) is considered an effective treatment strategy. By using AI-assisted hit optimization, we discovered a novel and highly selective compound with desired drug-like pro
Externí odkaz:
https://doaj.org/article/445be06eed3e476b882a2ba5e5bb36c0
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Antohe Ion, Dăscălescu Angela, Dănăilă Cătălin, Zlei Mihaela, Ivanov Iuliu, Sireteanu Adriana, Boca Oana, Oană Raluca, Cianga Petru
Publikováno v:
Romanian Journal of Laboratory Medicine, Vol 26, Iss 1, Pp 87-94 (2018)
Background: Acute basophilic leukemia is a rare subtype of acute myeloid leukemia, as categorized by the 2008 World Health Organization classification of myeloid neoplasms. Acute basophilic leukemia diagnosis requires thorough morphological, cytochem
Externí odkaz:
https://doaj.org/article/2c3530f121574bfbb0d03a0debdcb06c
Autor:
Fah Chueahongthong, Singkome Tima, Sawitree Chiampanichayakul, Cory Berkland, Songyot Anuchapreeda
Publikováno v:
Molecules, Vol 26, Iss 19, p 5785 (2021)
This study aims to enhance efficacy and reduce toxicity of the combination treatment of a drug and curcumin (Cur) on leukemic stem cell and leukemic cell lines, including KG-1a and KG-1 (FLT3+ LSCs), EoL-1 (FLT3+ LCs), and U937 (FLT3− LCs). The cyt
Externí odkaz:
https://doaj.org/article/d58354dc858c4f44affd06ab7c903b90
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Frontiers in Pediatrics, Vol 7 (2019)
Acute myeloid leukemia (AML) is a hematopoietic disorder characterized by numerous cytogenetic and molecular aberrations that accounts for ~25% of childhood leukemia diagnoses. The outcome of children with AML has increased remarkably over the past 3
Externí odkaz:
https://doaj.org/article/bdb8c38a19f84c23a8d9c8d0babd1574
Autor:
Claire Horgan, Alexandros Kanellopoulos, Shankara Paneesha, Bhuvan Kishore, Richard Lovell, Emmanouil Nikolousis
Publikováno v:
Hematology Reports, Vol 11, Iss 1 (2019)
A unique case of primary refractory FLT3-itd mutated acute myeloid leukemia in an elderly patient, who achieved completed morphological remission, and FLT3-itd negativity, following 9 cycles of azacitadine in combination with escalating doses of dono
Externí odkaz:
https://doaj.org/article/fc31f4a300514f2dba4cc08aee27fd64
Publikováno v:
Applied Sciences, Vol 11, Iss 9, p 3746 (2021)
Recently, we have reported a series of isatin hydrazone, two of them, namely, 3-((2,6-dichlorobenzylidene)hydrazono)indolin-2-one (1) and 3-((2-chloro-6-fluorobenzylidene)hydrazono)indolin-2-one (2) having potent cytotoxicity, showing cyclin-dependen
Externí odkaz:
https://doaj.org/article/1a69cfd4dfd84c8088c51e4e88c6cdf8