Zobrazeno 1 - 10
of 15
pro vyhledávání: '"FLIRI, A. F. J."'
Autor:
Raymond S. Hurst, Mihály Hajós, Dennis J. Hoover, William E. Hoffmann, Nandini Chaturbhai Patel, Christopher L. Shaffer, Xinjun J. Hou, Christopher J. O’Donnell, Dina McGinnis, Jayvardhan Pandit, Eric S. Marr, Randall James Gallaschun, Dianne K. Bryce, John T. Lazzaro, Longfei Xie, Jacob Bradley Schwarz, Fliri Anton F J, Justin L Gazard, Ashley N. Hanks, Renato J. Scialis
Publikováno v:
Journal of Medicinal Chemistry. 56:9180-9191
Positive allosteric modulators ("potentiators") of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPAR) enhance excitatory neurotransmission and may improve the cognitive deficits associated with various neurological disorde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56e4065349b607cc298e139b742e784
https://doi.org/10.1021/jm401274b
https://doi.org/10.1021/jm401274b
Publikováno v:
Nature Chemical Biology. 1:389-397
The high failure rate of experimental medicines in clinical trials accentuates inefficiencies of current drug discovery processes caused by a lack of tools for translating the information exchange between protein and organ system networks. Recently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed79dedfc381c1dd7b70678df65f15f
https://doi.org/10.1038/nchembio747
https://doi.org/10.1038/nchembio747
Publikováno v:
Proceedings of the National Academy of Sciences. 102:261-266
Establishing quantitative relationships between molecular structure and broad biological effects has been a longstanding challenge in science. Currently, no method exists for forecasting broad biological activity profiles of medicinal agents even wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7629fdf868f1284605caabab185fcf1
https://doi.org/10.1073/pnas.0407790101
https://doi.org/10.1073/pnas.0407790101
Publikováno v:
Current Opinion in Chemical Biology. 2:535-540
The identification of a novel dopamine receptor subtype, referred to as the D4 receptor, which binds the atypical antipsychoti drug clozapine with high potency, has led to the initiation of a drug discovery program that aims to find novel inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45b75b4e8f0f520b24087e458015c7e
https://doi.org/10.1016/s1367-5931(98)80131-2
https://doi.org/10.1016/s1367-5931(98)80131-2
Autor:
Fliri Anton F J, Kristopher Bosse, Robert A. Volkmann, Deane M. Nason, Barb E. Segelstein, Jason Marineau, Desai Kishor A
Publikováno v:
Tetrahedron Letters. 47:7285-7287
Use of alkyl substituted propylene linkers as a strategy for fine-tuning the biological activity of medicinal agents requires ready access to these substrates. Herein, a general strategy is described for stereospecifically generating 18 chiral mono-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0a80ccbffdb352df9b761d40d911b49
https://doi.org/10.1016/j.tetlet.2006.08.020
https://doi.org/10.1016/j.tetlet.2006.08.020
Publikováno v:
ChemInform. 22
N-(5-Fluorobenzothiazol-2-yl)-2-guanidinothiazole-4-carboxam ide (1) is a member of a series of amides found to substantially increase lifespan in mice bearing established micrometastatic 3LL Lewis lung carcinoma. Amide 1 is effective after either or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78a2742c9076ec06386798a5c4c0caf7
https://doi.org/10.1002/chin.199127170
https://doi.org/10.1002/chin.199127170
Publikováno v:
Trends in pharmacological sciences. 31(11)
Current target-based drug discovery platforms are not able to predict drug efficacy and the full spectrum of drug effects in organisms. Hence, many experimental drugs do not survive the lengthy and costly process of drug development. Understanding ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c685958c92e40ae77386749a5ffbf15
https://pubmed.ncbi.nlm.nih.gov/20810173
https://pubmed.ncbi.nlm.nih.gov/20810173
Publikováno v:
Journal of medicinal chemistry. 52(24)
Understanding how drugs affect cellular network structures and how resulting signals are translated into drug effects holds the key to the discovery of medicines. Herein we examine this cause-effect relationship by determining protein network structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4a3eb48fd7ceda45da018811c783c4
https://pubmed.ncbi.nlm.nih.gov/19891439
https://pubmed.ncbi.nlm.nih.gov/19891439
Autor:
Fliri Anton F J, Michelle Vanase-Frawley, Scot Richard Mente, Lorrie Lebel, Anne W. Schmidt, Randall James Gallaschun
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(23)
QSAR models have been used to evaluate activities for compounds in the phenoxyphenyl-methanamine (PPMA) class of compounds. These models utilize Hammett-type donating–withdrawing substituent values as well as simple parameters to describe substitue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739d5e5af8399df7e8051170087babb4
https://pubmed.ncbi.nlm.nih.gov/18948001
https://pubmed.ncbi.nlm.nih.gov/18948001
Publikováno v:
ChemMedChem. 2(12)
Preclinical pharmacology studies conducted with experimental medicines currently focus on assessments of drug effects attributed to a drug's putative mechanism of action. The high failure rate of medicines in clinical trials, however, underscores tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ac9e87119a0c32c5d9107ce53805d5
https://pubmed.ncbi.nlm.nih.gov/17952882
https://pubmed.ncbi.nlm.nih.gov/17952882