Zobrazeno 1 - 8
of 8
pro vyhledávání: '"FLAVIA A. GRAÇA"'
Autor:
IVANILDO I.S. JÚNIOR, GUSTAVO O. ZANETTI, TALES S. VIEIRA, FLÁVIA P. ALBUQUERQUE, DAYANE A. GOMES, SILVA PAULA-GOMES, RAFAEL R. VALENTIM, FLAVIA A. GRAÇA, ISIS C. KETTLHUT, LUIZ C.C. NAVEGANTES, DAWIT A.P. GONÇALVES, EDUARDO C. LIRA
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 95, Iss suppl 2 (2023)
Abstract Although there are reports that polyphenol resveratrol (Rsv) may cause muscle hypertrophy in basal conditions and attenuate muscle wasting in catabolic situations, its mechanism of action is still unclear. Our study evaluated the ex vivo eff
Externí odkaz:
https://doaj.org/article/970836906da6424c8d17d92a56a8a10b
Autor:
Liam C. Hunt, Vishwajeeth Pagala, Anna Stephan, Boer Xie, Kiran Kodali, Kanisha Kavdia, Yong-Dong Wang, Abbas Shirinifard, Michelle Curley, Flavia A. Graca, Yingxue Fu, Suresh Poudel, Yuxin Li, Xusheng Wang, Haiyan Tan, Junmin Peng, Fabio Demontis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Ubiquitination is a post-translational modification initiated by the E1 enzyme UBA1, which transfers ubiquitin to ~35 E2 ubiquitin-conjugating enzymes. While UBA1 loss is cell lethal, it remains unknown how partial reduction in UBA1 activity
Externí odkaz:
https://doaj.org/article/ecc3809ff4864ac888167d9faaecd3c0
Autor:
Flavia A. Graca, Anna Stephan, Benjamin A. Minden-Birkenmaier, Abbas Shirinifard, Yong-Dong Wang, Fabio Demontis, Myriam Labelle
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Skeletal muscle regeneration involves coordinated interactions between different cell types. Injection of platelet-rich plasma is circumstantially considered an aid to muscle repair but whether platelets promote regeneration beyond their rol
Externí odkaz:
https://doaj.org/article/1e5137075a244f59ae84e93d0ac6ec9e
Autor:
Flavia A. Graca, Mamta Rai, Liam C. Hunt, Anna Stephan, Yong-Dong Wang, Brittney Gordon, Ruishan Wang, Giovanni Quarato, Beisi Xu, Yiping Fan, Myriam Labelle, Fabio Demontis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Myofiber atrophy occurs in many diseases but the mechanisms responsible for myofiber size determination are incompletely understood. Here, the authors show that the muscle-secreted factor Fibcd1 is necessary to maintain myofiber size and mitigates my
Externí odkaz:
https://doaj.org/article/5cbdb4d779ef41379fe96cd79ef579e7
Autor:
Jianqin Jiao, Michelle Curley, Flavia A. Graca, Maricela Robles-Murguia, Abbas Shirinifard, David Finkelstein, Beisi Xu, Yiping Fan, Fabio Demontis
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111970- (2023)
Summary: Protein quality control is important for healthy aging and is dysregulated in age-related diseases. The autophagy-lysosome and ubiquitin-proteasome are key for proteostasis, but it remains largely unknown whether other proteolytic systems al
Externí odkaz:
https://doaj.org/article/bde9aaea4839427f897ff30d5ece83b5
Autor:
Flavia A. Graca, Anna Stephan, Yong-Dong Wang, Abbas Shirinifard, Jianqin Jiao, Peter Vogel, Myriam Labelle, Fabio Demontis
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111934- (2023)
Summary: Cachexia is a systemic wasting syndrome that increases cancer-associated mortality. How cachexia progressively and differentially impacts distinct tissues is largely unknown. Here, we find that the heart and skeletal muscle undergo wasting a
Externí odkaz:
https://doaj.org/article/8b4e26a5247340eaaa1128d017b8e539
Autor:
Mamta Rai, Michelle Curley, Zane Coleman, Anjana Nityanandam, Jianqin Jiao, Flavia A. Graca, Liam C. Hunt, Fabio Demontis
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100628- (2021)
Summary: Defects in protein quality control are the underlying cause of age-related diseases. The western blot analysis of detergent-soluble and insoluble protein fractions has proven useful in identifying interventions that regulate proteostasis. He
Externí odkaz:
https://doaj.org/article/ca4e981144da47cfa6ff526512179354
Autor:
Dawit A. Gonçalves, Wilian A. Silveira, Leandro H. Manfredi, Flávia A. Graça, Andrea Armani, Enrico Bertaggia, Brian T. O´Neill, Natalia Lautherbach, Juliano Machado, Leonardo Nogara, Marcelo G. Pereira, Diletta Arcidiacono, Stefano Realdon, C. Ronald Kahn, Marco Sandri, Isis C. Kettelhut, Luiz Carlos C. Navegantes
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 2, Pp 455-475 (2019)
Abstract Background Stimulation of β2‐adrenoceptors can promote muscle hypertrophy and fibre type shift, and it can counteract atrophy and weakness. The underlying mechanisms remain elusive. Methods Fed wild type (WT), 2‐day fasted WT, muscle‐
Externí odkaz:
https://doaj.org/article/f341a8776db04f97b5771d9cee49e3e4