FKS1 mutation associated with decreased echinocandin susceptibility of Aspergillus fumigatus following anidulafungin exposure.

Autor: e Silva, Ana Pinto^1,2 anatpsilva@hotmail.com, Miranda, Isabel Marcos³, Branco, Joana¹, Oliveira, Patricia¹, Faria-Ramos, Isabel¹, Silva, Raquel M.⁴, Rodrigues, Acácio Gonçalves^1,2,5, Costa-de-Oliveira, Sofia^1,2

Publikováno v: Scientific Reports. 7/20/2020, Vol. 10 Issue 1, p1-6. 6p.

Evolutionary accumulation of FKS1 mutations from clinical echinocandin-resistant Candida auris

Autor: Sufei Tian, Yusheng Wu, Hailong Li, Chen Rong, Na Wu, Yunzhuo Chu, Ning Jiang, Jingping Zhang, Hong Shang

Publikováno v: Emerging Microbes and Infections, Vol 13, Iss 1 (2024)

Introduction: Drug resistance to echinocandins, first-line drugs used to treat Candida auris infection, is rapidly emerging. However, the accumulation of mutations in genes other than FKS1 (before an isolate develops to resistance via FKS1 mutations)

Externí odkaz: https://doaj.org/article/9ef1e68a632245689a8bf3567ab0778a

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Echinocandin failure case due to a previously unreported fks1 mutation in candida krusei

Autor: Maiken Cavling Arendrup, Rasmus Hare Jensen, David S. Perlin, Annika Rewes, Ulrik Stenz Justesen

Publikováno v: Jensen, R H, Justesen, U S, Rewes, A, Perlin, D S & Arendrup, M C 2014, ' Echinocandin failure case due to a previously unreported fks1 mutation in candida krusei ', 24th European Congress of Clinical Microbiology and Infectious Diseases, Barcelona, Spain, 10/05/2014-13/05/2014 pp. 3550-3552 . https://doi.org/10.1128/AAC.02367-14
Jensen, R H, Justesen, U S, Rewes, A, Perlin, D S & Arendrup, M C 2014, ' Echinocandin Failure Case Due to a Previously Unreported FKS1 Mutation in Candida krusei ', Antimicrobial Agents and Chemotherapy, vol. 58, no. 6, pp. 3550-3552 . https://doi.org/10.1128/AAC.02367-14

Echinocandins are the preferred therapy for invasive infections due to Candida krusei . We present here a case of clinical failure involving C. krusei with a characteristic FKS1 hot spot mutation not previously reported in C. krusei that was isolated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b3eea6f60a1aec019d14f6ca73aab0
https://portal.findresearcher.sdu.dk/da/publications/8f4d7a51-f4db-44c3-bcf2-f54ea3ff4961

Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy

Autor: Maria Siopi, Antonios Papadopoulos, Anastasia Spiliopoulou, Fotini Paliogianni, Nissrine Abou-Chakra, Maiken Cavling Arendrup, Christina Damoulari, Georgios Tsioulos, Efthymia Giannitsioti, Frantzeska Frantzeskaki, Iraklis Tsangaris, Spyros Pournaras, Joseph Meletiadis

Publikováno v: Journal of Fungi, Vol 8, Iss 9, p 931 (2022)

The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin follow

Externí odkaz: https://doaj.org/article/e8f59495d9e247b88c9f4b2edcaf12bc