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Akademický článek

Characterisation of cardiac health in the reduced uterine perfusion pressure model and a 3D cardiac spheroid model, of preeclampsia

Autor: Claire Richards, Kimberly Sesperez, Michael Chhor, Sahar Ghorbanpour, Claire Rennie, Clara Liu Chung Ming, Chris Evenhuis, Valentina Nikolic, Natasa Karadzov Orlic, Zeljko Mikovic, Milan Stefanovic, Zoran Cakic, Kristine McGrath, Carmine Gentile, Kristen Bubb, Lana McClements

Publikováno v: Biology of Sex Differences, Vol 12, Iss 1, Pp 1-14 (2021)

Abstract Background Preeclampsia is a dangerous cardiovascular disorder of pregnancy that leads to an increased risk of future cardiovascular and metabolic disorders. Much of the pathogenesis and mechanisms involved in cardiac health in preeclampsia

Externí odkaz: https://doaj.org/article/e298c787ad634c4abdf69e5ca95e5ed7

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Akademický článek

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Akademický článek

FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4

Autor: Lana McClements, Stephanie Annett, Anita Yakkundi, Martin O’Rourke, Andrea Valentine, Nermeen Moustafa, Abdelrahim Alqudah, Bruno M. Simões, Fiona Furlong, Amy Short, Stuart A. McIntosh, Helen O. McCarthy, Robert B. Clarke, Tracy Robson

Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)

Abstract Background Optimising breast cancer treatment remains a challenge. Resistance to therapy is a major problem in both ER- and ER+ breast cancer. Tumour recurrence after chemotherapy and/or targeted therapy leads to more aggressive tumours with

Externí odkaz: https://doaj.org/article/2e02e553d486425d82cd0912d627c29b

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Akademický článek

Loss of Expression of Antiangiogenic Protein FKBPL in Endometrioid Endometrial Carcinoma: Implications for Clinical Practice

Autor: Danilo D. Obradović, Nataša M. Milić, Nenad Miladinović, Lana McClements, Dejan M. Oprić

Publikováno v: Medicina, Vol 58, Iss 10, p 1330 (2022)

Background and Objectives: FK506 binding protein like (FKBPL) is a member of the immunophilin family, with anti-angiogenic effects capable of inhibiting the migration of endothelial cells and blood vessel formation. Its role as an inhibitor of tumor

Externí odkaz: https://doaj.org/article/35c9e64a074c4a178cccc242b9d8d529

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Akademický článek

FKBPL and SIRT-1 Are Downregulated by Diabetes in Pregnancy Impacting on Angiogenesis and Endothelial Function

Autor: Abdelrahim Alqudah, Kelly-Ann Eastwood, Djurdja Jerotic, Naomi Todd, Denise Hoch, Ross McNally, Danilo Obradovic, Stefan Dugalic, Alyson J. Hunter, Valerie A. Holmes, David R. McCance, Ian S. Young, Chris J. Watson, Tracy Robson, Gernot Desoye, David J. Grieve, Lana McClements

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

Diabetes in pregnancy is associated with adverse pregnancy outcomes including preterm birth. Although the mechanisms leading to these pregnancy complications are still poorly understood, aberrant angiogenesis and endothelial dysfunction play a key ro

Externí odkaz: https://doaj.org/article/9da5fae60d9f4499b0224a5b05a2dc78

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Analysis of the expression of antiangiogenic FKBPL protein, vascular endothelial growth factor and estrogen receptor in uterine endometrioid carcinoma and benign endometrial hyperplasia

Autor: Obradović, Danilo

Publikováno v: Универзитет у Београду

ANALIZA EKSPRESIJE ANTIANGIOGENOG FKBPL PROTEINA, VASKULARNOG ENDOTELNOG FAKTORA RASTA I ESTROGENOG RECEPTORA U ENDOMETRIOIDNOM KARCINOMU UTERUSA I BENIGNOJ HIPERPLAZIJI ENDOMETRIJUMA Sažetak Uvod: FKBPL (FK506-binding protein-like), pripada familij

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=nardusnacion::e6d3ecc86b8b36c86446ff5a6f8fb6c4
https://nardus.mpn.gov.rs/handle/123456789/21469

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Akademický článek

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Akademický článek

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Akademický článek

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FK506-Binding Protein like (FKBPL) Has an Important Role in Heart Failure with Preserved Ejection Fraction Pathogenesis with Potential Diagnostic Utility

Autor: Michael Chhor, Hao Chen, Djurdja Jerotić, Milorad Tešić, Valentina N. Nikolić, Milan Pavlović, Rada M. Vučić, Benjamin Rayner, Chris J. Watson, Mark Ledwidge, Kenneth McDonald, Tracy Robson, Kristine C. McGrath, Lana McClements

Publikováno v: Biomolecules
Volume 13
Issue 2
Pages: 395
Chhor, M, Chen, H, Jerotić, D, Tešić, M, Nikolić, V N, Pavlović, M, Vučić, R M, Rayner, B, Watson, C J, Ledwidge, M, McDonald, K, Robson, T, McGrath, K C & McClements, L 2023, ' FK506-binding protein like (FKBPL) has an important role in heart failure with preserved ejection fraction pathogenesis with potential diagnostic utility ', Biomolecules, vol. 13, no. 2, 395 . https://doi.org/10.3390/biom13020395

Heart failure (HF) is the leading cause of hospitalisations worldwide, with only 35% of patients surviving the first 5 years after diagnosis. The pathogenesis of HF with preserved ejection fraction (HFpEF) is still unclear, impeding the implementatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf48dbdd71e7b013fdf443bc43104c63
https://doi.org/10.3390/biom13020395

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