Bile acids contribute to the development of non-alcoholic steatohepatitis in mice

Autor: Justine Gillard, Laure-Alix Clerbaux, Bart Staels, Anne Tailleux, Isabelle Leclercq, Laure B. Bindels, Maxime Nachit, Christine Sempoux

Publikováno v: JHEP reports, vol. 4, no. 1, pp. 100387
JHEP Reports, Vol 4, Iss 1, Pp 100387-(2022)
JHEP reports, Vol. 4, no.1, p. 100387 [1-13] (2022)
JHEP Reports

Background & Aims Through FXR and TGR5 signaling, bile acids (BAs) modulate lipid and glucose metabolism, inflammation and fibrosis. Hence, BAs returning to the liver after enteric secretion, modification and reabsorption may contribute to the pathog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f803f3cd8976e73d533d8b1885ead5
https://serval.unil.ch/notice/serval:BIB_8BED7E41CA16

Ablation of liver Fxr results in an increased colonic mucus barrier in mice

Autor: Ijssennagger, Noortje, van Rooijen, Kristel S., Magnúsdóttir, Stefanía, Ramos Pittol, José M., Willemsen, Ellen C.L., de Zoete, Marcel R., Baars, Matthijs J.D., Stege, Paul B., Colliva, Carolina, Pellicciari, Roberto, Youssef, Sameh A., de Bruin, Alain, Vercoulen, Yvonne, Kuipers, Folkert, van Mil, Saskia W.C., dI&I I&I-2, Dep Biomolecular Health Sciences, Pathobiologie, dPB RMSC

Publikováno v: JHEP Reports, 3(5). Elsevier BV
JHEP reports : innovation in hepatology, 3(5):100344. Elsevier
JHEP Reports, Vol 3, Iss 5, Pp 100344-(2021)
JHEP Reports

Background & Aims The interorgan crosstalk between the liver and the intestine has been the focus of intense research. Key in this crosstalk are bile acids, which are secreted from the liver into the intestine, interact with the microbiome, and upon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72552e39408b54b1d6b3f7ac049c554
https://research.rug.nl/en/publications/6d114c7d-e702-4429-b4f3-185d79b7792b

Role of farnesoid X receptor and bile acids in alcoholic liver disease

Autor: Wen-Xing Ding, Sharon Manley

Publikováno v: Acta Pharmaceutica Sinica B, Vol 5, Iss 2, Pp 158-167 (2015)
Acta Pharmaceutica Sinica. B

Alcoholic liver disease (ALD) is one of the major causes of liver morbidity and mortality worldwide. Chronic alcohol consumption leads to development of liver pathogenesis encompassing steatosis, inflammation, fibrosis, cirrhosis, and in extreme case

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe90bd1931d9f326a7aef4997061bbe

Bile acids contribute to the development of non-alcoholic steatohepatitis in mice.

Autor: Gillard J; Laboratory of Hepato-Gastroenterology, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium.; Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium., Clerbaux LA; Laboratory of Hepato-Gastroenterology, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium., Nachit M; Laboratory of Hepato-Gastroenterology, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium., Sempoux C; Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland., Staels B; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France., Bindels LB; Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium., Tailleux A; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France., Leclercq IA; Laboratory of Hepato-Gastroenterology, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium.

Publikováno v: JHEP reports : innovation in hepatology [JHEP Rep] 2021 Oct 13; Vol. 4 (1), pp. 100387. Date of Electronic Publication: 2021 Oct 13 (Print Publication: 2022).

Bile acid nuclear receptor FXR and digestive system diseases.

Autor: Ding L; Shanghai Key Laboratory of Complex Prescriptions and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China ; Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA., Yang L; Shanghai Key Laboratory of Complex Prescriptions and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Wang Z; Shanghai Key Laboratory of Complex Prescriptions and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Huang W; Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.

Publikováno v: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2015 Mar; Vol. 5 (2), pp. 135-44. Date of Electronic Publication: 2015 Feb 25.