Zobrazeno 1 - 10
of 2 691
pro vyhledávání: '"FGFR3"'
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Urinary bladder cancer, is the 10th most common global cancer, diagnosed in over 600,000 people causing 200,000 deaths annually. Artemisinin and its derivatives are safe compounds that have recently been proven to possess potent a
Externí odkaz:
https://doaj.org/article/bcaa36ca5ad241e8adea5a6f82983709
Publikováno v:
Nigerian Journal of Paediatrics, Vol 47, Iss 3, Pp 277-279 (2024)
Thanatophoric dysplasia is a lethal form of skeletal dysplasia seen in neonates. The word ‘thanatophoric’ is derived from the Greek word thanatophorus meaning death bringing. Thanatophoric dysplasia results from mutations within the Fibroblast Gr
Externí odkaz:
https://doaj.org/article/0900439d31244af7a8f4d8c633319805
Publikováno v:
Endocrine Journal, Vol 71, Iss 7, Pp 643-650 (2024)
Achondroplasia (ACH) is a representative skeletal disorder characterized by rhizomelic shortened limbs and short stature. ACH is classified as belonging to the fibroblast growth factor receptor 3 (FGFR3) group. The downstream signal transduction of F
Externí odkaz:
https://doaj.org/article/f10d452caa274538b4c80158bd60eb0d
Autor:
Philippe Metellus, Clara Camilla, Emilie Bialecki, Nathalie Beaufils, Christine Vellutini, Eric Pellegrino, Pascale Tomasini, Manmeet S. Ahluwalia, Alireza Mansouri, Isabelle Nanni, L’Houcine Ouafik
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundOncogenic fusions of neurotrophic receptor tyrosine kinase NTRK1, NTRK2, or NTRK3 genes have been found in different types of solid tumors. The treatment of patients with TRK fusion cancer with a first-generation TRK inhibitor (such as laro
Externí odkaz:
https://doaj.org/article/ed3fc3c4abd840519e77be3825438190
Autor:
XinZhong Zhang, Shan Jiang, Rui Zhang, Siyi Guo, Qiqi Sheng, Kaili Wang, Yuanyuan Shan, Lin Liao, Jianjun Dong
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-10 (2024)
Abstract Aim Achondroplasia is the most common of the skeletal dysplasias that cause fatal and disabling growth and developmental disorders in children, and is caused by a mutation in the fibroblast growth factor receptor, type 3 gene(FGFR3). This st
Externí odkaz:
https://doaj.org/article/81d09085652d4b36bdd5af7aac3f9392
Autor:
Pan Li, Dong Wang, Weiguang Lu, Xin He, Jingyan Hu, Haitao Yun, Chengxiang Zhao, Liu Yang, Qiang Jie, Zhuojing Luo
Publikováno v:
Journal of Orthopaedic Translation, Vol 44, Iss , Pp 88-101 (2024)
Background: Mutations in Slc26a2 cause a spectrum of autosomal-recessive chondrodysplasia with a significant and negligible influence on the quality of life. It has been reported that Slc26a2 deficiency triggers the ATF6 branch of the UPR, which may,
Externí odkaz:
https://doaj.org/article/8d44760a55274dc2a30c7de894e201f8
Autor:
Qingxin Zeng, Haichuan Hu, Zhengwei Huang, Aotian Guo, Sheng Lu, Wenbin Tong, Zhongheng Zhang, Tao Shen
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Introduction: This study bridges traditional remedies and modern pharmacology by exploring the synergy between natural compounds and Ceritinib in treating Non-Small Cell Lung Cancer (NSCLC), aiming to enhance efficacy and reduce toxicities.Methods: U
Externí odkaz:
https://doaj.org/article/d66ca38986a14ebcac7ed73537e5a83e
Publikováno v:
Diagnostic Pathology, Vol 18, Iss 1, Pp 1-9 (2023)
Abstract Background Renal transplant recipients (RTRs) have a 3- to 5-fold higher risk of developing malignant tumors than the general population, with new malignant tumors after transplantation considered to be the leading cause of death in RTRs. In
Externí odkaz:
https://doaj.org/article/039f907c9ec349e2bba403fc8c0709e8
Autor:
Daniel R. Bergman, Yixuan Wang, Erica Trujillo, Anthony A. Fernald, Lie Li, Alexander T. Pearson, Randy F. Sweis, Trachette L. Jackson
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Bladder cancer is an increasingly prevalent global disease that continues to cause morbidity and mortality despite recent advances in treatment. Immune checkpoint inhibitors (ICI) and fibroblast growth factor receptor (FGFR)-targeted therapeutics hav
Externí odkaz:
https://doaj.org/article/47f612fceba0467fa1c634ad054c7f8d
Publikováno v:
Cancer Medicine, Vol 12, Iss 14, Pp 15676-15690 (2023)
Abstract Background Improving the potency of immune response is paramount among issues concerning immunotherapy of muscle‐invasive bladder cancer (MIBC). Methods On the basis of immune subtypes, we investigated possible molecular mechanisms involve
Externí odkaz:
https://doaj.org/article/7fff4c4cf0004a248c6365834c92f237