Zobrazeno 1 - 10
of 79
pro vyhledávání: '"FGFR, fibroblast growth factor receptor"'
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2024)
BackgroundModern chemotherapeutic agents continue to evolve as modern monoclonal antibody treatments are designed to directly target proteins, enzymes, and focal loci. A particular class of these medications, fibroblast growth factor (FGFR) inhibitor
Externí odkaz:
https://doaj.org/article/7a561a7fe9e7417f97bed9f420450cf9
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Fibroblast growth factor 18(FGF18) is a member of the fibroblast growth factor family (FGFs). FGF18 is a class of bioactive substances that can conduct biological signals, regulate cell growth, participate in tissue repair and other functions, and ca
Externí odkaz:
https://doaj.org/article/0f47c04a963248a0b39c6c4771914fdc
Autor:
Giovanni Vitale, Alessia Cozzolino, Pasqualino Malandrino, Roberto Minotta, Giulia Puliani, Davide Saronni, Antongiulio Faggiano, Annamaria Colao
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors originating from neuroendocrine cells dispersed in different organs. Receptor tyrosine kinases are a subclass of tyrosine kinases with a relevant role in several cellular processes i
Externí odkaz:
https://doaj.org/article/8bf131702f3949a9a1b072c1a744f288
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 24, Iss 1, Pp 34-49 (2022)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Highlights • GNF-7, a multi-targeted kinase inhibitor, is highly potent against FGFR4. • GNF-7 and SIJ1263 are highly potent on Ba/F3 cells with wtFGFR4 or mtFGFR4. • GNF-7 and SIJ1263 are highly potent on HCC cells with FGFR4 activation. • G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4404b111edeadaa6237d4a7297c304e
https://doi.org/10.1016/j.neo.2021.11.011
https://doi.org/10.1016/j.neo.2021.11.011
Autor:
Chenxi Zhao, Hong Zhu, Xiaoyang Dai, Weihua Wang, Meijia Qian, Xin Dong, Nengming Lin, Jiao Wang, Jiabin Lu, Bo Yang, Qiaojun He, Xiaowu Dong, Fangjie Yan, Tao Yuan, Bo Zhang, Jiamin Du, Ruilin Wu
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 4008-4019 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 4008-4019 (2021)
Cholangiocarcinoma (CCA) has emerged as an intractable cancer with scanty therapeutic regimens. The aberrant activation of Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are reported to be common in CCA pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626f01f78adbe5f9659fdd17326d365a
http://europepmc.org/articles/PMC8727894
http://europepmc.org/articles/PMC8727894
Autor:
Kaidonis, Georgia, Pekmezci, Melike, Van Ziffle, Jessica, Auguste, Kurtis I, Horton, Jonathan C
Publikováno v:
Journal of neurosurgery. Case lessons, vol 3, iss 23
BACKGROUND In the past decade, next-generation sequencing has spurred significant progress in the understanding of cytogenetic alterations that occur in meningiomas. Eighty percent of adult meningiomas harbor pathogenic somatic variants involving NF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f43346690f3db1716396b938997aca
https://doi.org/10.3171/case2247
https://doi.org/10.3171/case2247
Akademický článek
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Autor:
Alexandre Gries, Michael A. Grotzer, Anuja Neve, Marc Thomas Schönholzer, Min Ma, Karthiga Santhana Kumar, Martin Baumgartner, Jessica Migliavacca, Elena Alvarez
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 10, Pp 470-483 (2020)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 10, Pp 470-483 (2020)
Highlights • Growth factor signaling causes sustained nuclear ERK1/2 activation. • The SCR and BCR/ABL inhibitor dasatinib blocks ERK1/2 and represses cell invasion. • EGF-stimulated cells may escape dasatinib inhibition of invasion through mes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a076863a1a0810fcffc300433bde15b
http://europepmc.org/articles/PMC7452206
http://europepmc.org/articles/PMC7452206
Publikováno v:
JAAD Case Reports, Vol 6, Iss 2, Pp 79-82 (2020)
JAAD Case Reports
JAAD Case Reports
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6952cea3f9068b26702e06804c6d62
http://www.sciencedirect.com/science/article/pii/S2352512619306757
http://www.sciencedirect.com/science/article/pii/S2352512619306757
Autor:
Dhanya Raveendra-Panickar, Darren Finlay, Fabiana Izidro Layng, Lester J. Lambert, Maria Celeridad, Ming Zhao, Karina Barbosa, Laurent J.S. De Backer, Elizabeth Kwong, Palak Gosalia, Socorro Rodiles, John Holleran, Robert Ardecky, Stefan Grotegut, Steven Olson, John H. Hutchinson, Elena B. Pasquale, Kristiina Vuori, Aniruddha J. Deshpande, Nicholas D.P. Cosford, Lutz Tautz
Publikováno v:
The Journal of Biological Chemistry
Disturbance of the dynamic balance between tyrosine phosphorylation and dephosphorylation of signaling molecules, controlled by protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is known to lead to the development of cancer. While mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29990762ad8fbd140f872fdc58a3cd6
http://europepmc.org/articles/PMC8760490
http://europepmc.org/articles/PMC8760490