Targeting Cholesterol Metabolism as Efficient Antiviral Strategy Against the Hepatitis E VirusSummary

Autor: Evelyn Seelow, Eberhard Hildt, Denna Tabari, Kathrin Woytinek, David Heiler Martín, Catharina Scholl, Julia C. Stingl, Mira Choi, Benjamin Schmidt, Mirco Glitscher

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 159-180 (2021)
Cellular and Molecular Gastroenterology and Hepatology : CMGH 12, 159-180 (2021). doi:10.1016/j.jcmgh.2021.02.002
Cellular and Molecular Gastroenterology and Hepatology, 12(1):159-180
Cellular and Molecular Gastroenterology and Hepatology

Background and aims The Hepatitis E virus hijacks the endosomal system for its release. These structures are highly dependent on cholesterol. Hence, this study investigates the impact of HEV on cholesterol-metabolism, the effect of intracellular chol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f49a05084d5deba44d573f372cd16e
http://www.sciencedirect.com/science/article/pii/S2352345X21000357

Potent suppression of hydrophobic bile acids by aldafermin, an FGF19 analogue, across metabolic and cholestatic liver diseases

Autor: Hsiao D. Lieu, Gideon M. Hirschfield, Arun J. Sanyal, Stephen A. Harrison, Lei Ling, Ulrich Beuers, Alex M. DePaoli

Publikováno v: JHEP Reports
JHEP Reports, Vol 3, Iss 3, Pp 100255-(2021)
JHEP Reports, 3(3):100255. Elsevier

Summary Background & Aims Higher serum bile acid levels are associated with an increased risk of cirrhosis and liver-related morbidity and mortality. Herein, we report secondary analyses of aldafermin, an engineered analogue of the gut hormone fibrob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7001e197981d0d939e7dc5af50542f
https://pubmed.ncbi.nlm.nih.gov/33898959

Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: Current and innovative therapeutic approaches

Autor: F. Tuccillo, Joseph L. Evans, Antonella Borrelli, Franco M. Buonaguro, Ira D. Goldfine, P. Bonelli, Aldo Mancini

Publikováno v: Redox Biology, Vol 15, Iss C, Pp 467-479 (2018)
Redox Biology

Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease in industrialized countries. NAFLD progresses through the inflammatory phase of non-alcoholic steatohepatitis (NASH) to fibrosis and cirrhosis, with some cases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2419fc2467afc0fef89a4f91dd16f4c
http://www.sciencedirect.com/science/article/pii/S2213231717309291

The KLB rs17618244 gene variant is associated with fibrosing MAFLD by promoting hepatic stellate cell activation

Autor: Luca Miele, Erika Paolini, Miriam Longo, Valentina D'Oria, Annalisa Crudele, Marco Maggioni, Luca Valenti, Marica Meroni, Paola Dongiovanni, Emanuele Bellacchio, Anna Alisi, Nadia Panera, Anna Ludovica Fracanzani

Publikováno v: EBioMedicine
EBioMedicine, Vol 65, Iss, Pp 103249-(2021)

Background The rs17618244 G>A β-Klotho (KLB) variant has been associated with increased risk of ballooning and inflammation in pediatric patients with metabolic associated fatty liver disease (MAFLD), by reducing KLB expression. In hepatocytes, KLB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b73168cc030189c281702ac035f66d
https://doi.org/10.1016/j.ebiom.2021.103249

Bile acid nuclear receptor FXR and digestive system diseases

Autor: Zhengtao Wang, Lili Ding, Wendong Huang, Li Yang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 5, Iss 2, Pp 135-144 (2015)

Bile acids (BAs) are not only digestive surfactants but also important cell signaling molecules, which stimulate several signaling pathways to regulate some important biological processes. The bile-acid-activated nuclear receptor, farnesoid X recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32af3a3fcea93a38dfa12c2417846ae