Zobrazeno 1 - 10
of 564
pro vyhledávání: '"FGF15"'
Autor:
Weijia Cai, Canye Li, Zuanjun Su, Jinming Cao, Zhicong Chen, Yitian Chen, Zhijun Guo, Jian Cai, Feng Xu
Publikováno v:
PeerJ, Vol 11, p e16407 (2023)
Background Imbalances in bile acid (BA) synthesis and metabolism are involved in the onset of diabetes and depression in humans and rodents. However, the role of BAs and the farnesoid X receptor (FXR)/fibroblast growth factor (FGF) 15 signaling pathw
Externí odkaz:
https://doaj.org/article/a008303c4067490da5b7beeb3646fcfa
Autor:
David J. Matye, Xuan Qin, Mohammad Nazmul Hasan, Lijie Gu, Yung Dai Clayton, Feng Li, Tiangang Li
Publikováno v:
Liver Research, Vol 6, Iss 4, Pp 276-283 (2022)
Background and aims: Several bile acids-based monotherapies have been developed for non-alcoholic steatohepatitis (NASH) treatment but clinical trial findings suggest that they do not satisfactorily improve NASH and liver fibrosis in many patients. R
Externí odkaz:
https://doaj.org/article/beea8ecf722143c8bf8cb6f59073c383
Publikováno v:
Nutrition & Metabolism, Vol 19, Iss 1, Pp 1-11 (2022)
Abstract Background Insulin resistance precedes metabolic syndrome which increases the risk of type 2 diabetes and cardiovascular disease. However, there is a lack of safe and long-lasting methods for the prevention and treatment of insulin resistanc
Externí odkaz:
https://doaj.org/article/a31b6c7fb95f48f99ce1ada427fdacb8
Publikováno v:
Journal of Inflammation Research, Vol Volume 15, Pp 6187-6197 (2022)
Xing Li,1– 3 Zexiang Zhu,3 Zhenkun Xia,4 Bo Xu1,2 1Department of Anesthesiology, The First Clinical College of Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Anesthesiology, General Hospital of the Southern The
Externí odkaz:
https://doaj.org/article/a6fc285cd35d437588d60c27a3dda498
Autor:
Pingfan Mo, Hongtan Chen, Xin Jiang, Fengling Hu, Fenming Zhang, Guodong Shan, Wenguo Chen, Sha Li, Yiqiao Li, Guoqiang Xu
Publikováno v:
Lipids in Health and Disease, Vol 21, Iss 1, Pp 1-13 (2022)
Abstract Background Cholesterol gallstone disease (CGD) is accompanied by biliary cholesterol supersaturation. Hepatic Niemann-Pick C1-like 1 (NPC1L1), which is present in humans but not in wild-type (WT) mice, promotes hepatocyte cholesterol uptake
Externí odkaz:
https://doaj.org/article/173974eb9e6040c3a997f2e27fabdcc7
Autor:
Bo Kong, Mingxing Huang, Rulaiha E. Taylor, Daniel Rizzolo, Katherine D. Otersen, Grace L. Guo
Publikováno v:
Liver Research, Vol 6, Iss 2, Pp 84-92 (2022)
Background and aims: Alcoholic liver disease (ALD) is an important and growing cause for the development of chronic liver diseases in the world. Bile acid (BA) levels are increased in patients with ALD and dysregulation of BA homeostasis worsens ALD.
Externí odkaz:
https://doaj.org/article/461bb4ea63bf455db71e6912a86a5016
Autor:
Katsunori Nonogaki, Takao Kaji
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Farnesoid X receptor (FXR) and Takeda G protein-coupled Receptor 5 (TGR5), the intestinal bile acid (BA) receptors, regulate the gut-derived hormones including fibroblast growth factor 15/19 (FGF15/19) and serotonin (5-hydrooxytryptamine, 5-HT). Here
Externí odkaz:
https://doaj.org/article/18907a92c5bf4bad87e66f4ff99023e1
Autor:
Syeda Maliha, Grace L. Guo
Publikováno v:
Liver Research, Vol 5, Iss 3, Pp 142-150 (2021)
The farnesoid X receptor (FXR) is a nuclear receptor and transcriptional regulator activated by bile acids or synthetic FXR agonists. FXR is expressed highly in the liver and intestine where modulation of FXR critically regulates the expression of ge
Externí odkaz:
https://doaj.org/article/ab8fb08505ad4f919575ddd3c7efed2a
Autor:
Shengnan Zhou, Weijie Chen, Xuesong Bai, Jiemin Chen, Qiang Xu, Liangbo Dong, Wei Chen, Qiang Qu, Xiaodong He
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
BackgroundBile acids are important signaling molecules that might activate hypothalamic neurons. This study aimed to investigate possible changes in hypothalamic pro-opiomelanocortin (POMC) neurons after biliary diversion in diabetic rats.MethodsTen
Externí odkaz:
https://doaj.org/article/512f151b36e946dc83d6de2e29505610
Autor:
Xin Ye, Dan Huang, Zhixia Dong, Xiaoxin Wang, Min Ning, Jie Xia, Shuang Shen, Shan Wu, Yan Shi, Jingjing Wang, Xinjian Wan
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Cholesterol gallstone (CGS) disease is characterized by an imbalance in bile acid (BA) metabolism and is closely associated with gut microbiota disorders. However, the role and mechanism by which probiotics targeting the gut microbiota atten
Externí odkaz:
https://doaj.org/article/296920807a084eecadda881235b99ff1