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Akademický článek

Pathways in small cell lung cancer and its therapeutic perspectives

Autor: Pingali M. Shivapriya, Anirudh Singh, Priyanshu Pandey, Nandini Chhabra, Amaresh Kumar Sahoo, Biswaranjan Paital, Pritish Kumar Varadwaj, Sintu Kumar Samanta

Publikováno v: Frontiers in Bioscience-Landmark, Vol 26, Iss 12, Pp 1668-1678 (2021)

Small cell lung cancer (SCLC) is known for its rapid growth with high metastatic spread. Its treatment remains a major challenge for oncologists due to the high mutation rate and other clinical disadvantages. The survival rate of these patients is ve

Externí odkaz: https://doaj.org/article/8f4e1982031d40739cd57f9944598742

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Akademický článek

Role of FGF Receptors and Their Pathways in Adrenocortical Tumors and Possible Therapeutic Implications

Autor: Iuliu Sbiera, Stefan Kircher, Barbara Altieri, Kerstin Lenz, Constanze Hantel, Martin Fassnacht, Silviu Sbiera, Matthias Kroiss

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy and treatment of advanced disease is challenging. Clinical trials with multi-tyrosine kinase inhibitors in the past have yielded disappointing results. Here, we investigated fibroblast gro

Externí odkaz: https://doaj.org/article/9e83a1edfae5460297374a0abbff6473

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Akademický článek

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Akademický článek

Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration

Autor: Lu Wei, Amir Al Oustah, Patrick Blader, Myriam Roussigné

Publikováno v: eLife, Vol 8 (2019)

Coordinated migration of cell collectives is important during embryonic development and relies on cells integrating multiple mechanical and chemical cues. Recently, we described that focal activation of the FGF pathway promotes the migration of the p

Externí odkaz: https://doaj.org/article/f2984a701c614690b817a4bd34d82bfa

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Akademický článek

Topically Applied Etamsylate: A New Orphan Drug for HHT-Derived Epistaxis (Antiangiogenesis through FGF Pathway Inhibition)

Autor: Virginia Albiñana, Guillermo Giménez-Gallego, Angela García-Mato, Patricia Palacios, Lucia Recio-Poveda, Angel-M Cuesta, José-Luis Patier, Luisa-María Botella

Publikováno v: TH Open, Vol 03, Iss 03, Pp e230-e243 (2019)

Hereditary hemorrhagic telangiectasia (HHT) is a vascular dysplasia characterized by recurrent and spontaneous epistaxis (nose bleeds), telangiectases on skin and mucosa, internal organ arteriovenous malformations, and dominant autosomal inheritance.

Externí odkaz: https://doaj.org/article/02fb504621504e31997fc759d8991017

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vwa1 Knockout in Zebrafish Causes Abnormal Craniofacial Chondrogenesis by Regulating FGF Pathway

Autor: Xiaomin Niu, Fuyu Zhang, Lu Ping, Yibei Wang, Bo Zhang, Jian Wang, Xiaowei Chen

Publikováno v: Genes; Volume 14; Issue 4; Pages: 838

Hemifacial microsomia (HFM), a rare disorder of first- and second-pharyngeal arch development, has been linked to a point mutation in VWA1 (von Willebrand factor A domain containing 1), encoding the protein WARP in a five-generation pedigree. However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24895c139a4ee14dfff63db2b8e9eaf8

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Akademický článek

Inhibition of FGF and TGF-β Pathways in hESCs Identify STOX2 as a Novel SMAD2/4 Cofactor

Autor: Peter F. Renz, Daniel Spies, Panagiota Tsikrika, Anton Wutz, Tobias A. Beyer, Constance Ciaudo

Publikováno v: Biology, Vol 9, Iss 12, p 470 (2020)

The fibroblast growth factor (FGF) and the transforming growth factor-β (TGF-β) pathways are both involved in the maintenance of human embryonic stem cells (hESCs) and regulate the onset of their differentiation. Their converging functions have sug

Externí odkaz: https://doaj.org/article/922a131c6b584b38a2bf5ebbc370ace8

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Akademický článek

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Topically Applied Etamsylate: A New Orphan Drug for HHT-Derived Epistaxis (Antiangiogenesis through FGF Pathway Inhibition)

Autor: Guillermo Giménez-Gallego, Luisa María Botella, Ángela García-Mato, José-Luis Patier, Virginia Albiñana, Angel Cuesta, Lucía Recio-Poveda, Patricia Palacios

Publikováno v: TH Open, Vol 03, Iss 03, Pp e230-e243 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
TH Open: Companion Journal to Thrombosis and Haemostasis

14 p.-8 fig.-1 tab
Hereditary hemorrhagic telangiectasia (HHT) is a vascular dysplasia characterized by recurrent and spontaneous epistaxis (nose bleeds), telangiectases on skin and mucosa, internal organ arteriovenous malformations, and dominan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1933fdf6856603ccdcd9b39d81b127
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1693710

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Inhibition of FGF and TGF-β Pathways in hESCs Identify STOX2 as a Novel SMAD2/4 Cofactor

Autor: Constance Ciaudo, Tobias A. Beyer, Panagiota Tsikrika, Peter F. Renz, Daniel Spies, Anton Wutz

Publikováno v: Biology, Vol 9, Iss 470, p 470 (2020)
Biology, 9 (12)
Biology
Volume 9
Issue 12

The fibroblast growth factor (FGF) and the transforming growth factor-&beta
(TGF-&beta
) pathways are both involved in the maintenance of human embryonic stem cells (hESCs) and regulate the onset of their differentiation. Their converging f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe03964e7497dc719c0898e56c3d30d
https://www.mdpi.com/2079-7737/9/12/470

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