Therapeutic regulation of autophagy in hepatic metabolism

Autor: Niani Tiaye Bailey, Bilon Khambu, Gang Liu, Sophia Blessinger, Katherine Byrnes, Russell Scaife

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 33-49 (2022)

Metabolic homeostasis requires dynamic catabolic and anabolic processes. Autophagy, an intracellular lysosomal degradative pathway, can rewire cellular metabolism linking catabolic to anabolic processes and thus sustain homeostasis. This is especiall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58c0ac6db641c550d04c5a5c6ba5a1a
https://doi.org/10.1016/j.apsb.2021.07.021

Fatty Acids Activate the Transcriptional Coactivator YAP1 to Promote Liver Fibrosis via p38 Mitogen-Activated Protein Kinase

Autor: Nadia Alatrakchi, Tuo Shao, Myung-Ho Kim, Wenyu Lin, Shadi Salloum, Raymond T. Chung, Annie J. Kruger, Andre J Jeyarajan, Kathleen E. Corey, Stuti Shroff, Andrew Kassa, Zhu Zhuo, Sanjoy K. Khan, Mozhdeh Sojoodi, Jacinta A Holmes, Esperance A. Schaefer

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1297-1310 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Patients with simple steatosis (SS) and nonalcoholic steatohepatitis can develop progressive liver fibrosis, which is associated with liver-related mortality. The mechanisms contributing to liver fibrosis development in SS, however,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e12cc853a36cd441fcfaf543a427312
http://www.sciencedirect.com/science/article/pii/S2352345X21001181

Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner

Autor: Aldons J. Lusis, Raquel Floyd, Simon Sabir, Miklós Péterfy, Paola León-Mimila, Anthony E. Jones, Linsey Stiles, Dulshan W. Jayasekera, Samuel Canizales-Quinteros, Adriana Huertas-Vazquez, Varun Shravah, Angel A. Cortez, Karthickeyan Chella Krishnan, Ajit S. Divakaruni

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 11, iss 2

Background & Aims The etiology of nonalcoholic fatty liver disease (NAFLD) is poorly understood, with males and certain populations exhibiting markedly increased susceptibility. Using a systems genetics approach involving multi-omic analysis of ∼10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4127e52760363929df8a11fd651eca
http://europepmc.org/articles/PMC7788245

E-Selectin-Dependent Inflammation and Lipolysis in Adipose Tissue Exacerbate Steatosis-to-NASH Progression via S100A8/9

Autor: Adeline Bertola, Yeni Ait-Ahmed, Jing Ma, Bin Gao, Yukun Guan, Dechun Feng, Tamara Vanhaecke, Robim Marcelino Rodrigues, Bryan Mackowiak, Yaojie Fu, Xiaolin Wang, Wonhyo Seo, Seonghwan Hwang, Seol Hee Park, Yong He

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 151-171 (2022)

Background & Aims Nonalcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease, characterized by steatosis and hallmark liver neutrophil infiltration. NASH also is associated with adipose tissue inflammation, but the role of adipos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b081b10329fc04385b5e0d0855f694
https://biblio.vub.ac.be/vubir/eselectindependent-inflammation-and-lipolysis-in-adipose-tissue-exacerbate-steatosistonash-progression-via-s100a89(8daeb805-6a0b-4ba8-b9f4-f7e041564b4f).html

Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease

Autor: Aidan J. McGlinchey, Olivier Govaere, Dawei Geng, Vlad Ratziu, Michael Allison, Jerome Bousier, Salvatore Petta, Claudia de Oliviera, Elisabetta Bugianesi, Jörn M. Schattenberg, Ann K. Daly, Tuulia Hyötyläinen, Quentin M. Anstee, Matej Orešič

Publikováno v: JHEP Reports

Funder: European Commission
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is a progressive liver disease with potentially severe complications including cirrhosis and hepatocellular carcinoma. Previously, we have identified circul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dccc15694575d45eb24a234f95e9680
https://pubmed.ncbi.nlm.nih.gov/35434590