Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia

Autor: Ff, Ferrara, Fazi F, Bianchini A, Padula F, Gelmetti V, Minucci S, Mancini M, Pg, Pelicci, Lo Coco F, Clara NERVI

Publikováno v: Scopus-Elsevier
Publons
Europe PubMed Central

Histone deacetylase (HDAC)-dependent transcriptional repression of the retinoic acid (RA)-signaling pathway underlies the differentiation block of acute promyelocytic leukemia. RA treatment relieves transcriptional repression and triggers differentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::22655ee5a722810b685827c0567b67a9
https://pubmed.ncbi.nlm.nih.gov/11196162

Antitumor activity of the combination of synthetic retinoid ST1926 and cisplatin in ovarian carcinoma models.

Autor: C Pisano, L Vesci, R Foderà, FF Ferrara, C Rossi, M De Cesare, V Zuco, G Pratesi, R Supino, F Zunino

Publikováno v: Annals of Oncology. Sep2007, Vol. 18 Issue 9, p1500-1500. 1p.

COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models.

Autor: Conforti A; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy; Evvivax Biotech, Via Castel Romano 100, 00128 Rome, Italy., Marra E; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., Palombo F; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy; Neomatrix Biotech, Via Castel Romano 100, 00128 Rome, Italy., Roscilli G; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., Ravà M; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Fumagalli V; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; Vita-Salute San Raffaele University, 20132 Milan, Italy., Muzi A; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., Maffei M; Evvivax Biotech, Via Castel Romano 100, 00128 Rome, Italy., Luberto L; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., Lione L; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., Salvatori E; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., Compagnone M; Neomatrix Biotech, Via Castel Romano 100, 00128 Rome, Italy., Pinto E; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., Pavoni E; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., Bucci F; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., Vitagliano G; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., Stoppoloni D; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., Pacello ML; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., Cappelletti M; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., Ferrara FF; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., D'Acunto E; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., Chiarini V; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., Arriga R; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy., Nyska A; Sackler School of Medicine, Tel Aviv University, Haharuv 18, PO Box 184, Timrat 36576, Israel., Di Lucia P; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Marotta D; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; Vita-Salute San Raffaele University, 20132 Milan, Italy., Bono E; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Giustini L; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Sala E; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; Vita-Salute San Raffaele University, 20132 Milan, Italy., Perucchini C; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Paterson J; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire SP4 0JG, UK., Ryan KA; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire SP4 0JG, UK., Challis AR; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire SP4 0JG, UK., Matusali G; National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149 Rome, Italy., Colavita F; National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149 Rome, Italy., Caselli G; Rottapharm Biotech s.r.l., Via Valosa di Sopra 9, 20900 Monza, Italy., Criscuolo E; Vita-Salute San Raffaele University, 20132 Milan, Italy., Clementi N; Vita-Salute San Raffaele University, 20132 Milan, Italy; Laboratory of Microbiology and Virology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Mancini N; Vita-Salute San Raffaele University, 20132 Milan, Italy; Laboratory of Microbiology and Virology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Groß R; Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstr. 1, 89081 Ulm, Germany., Seidel A; Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstr. 1, 89081 Ulm, Germany., Wettstein L; Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstr. 1, 89081 Ulm, Germany., Münch J; Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstr. 1, 89081 Ulm, Germany., Donnici L; INGM-Istituto Nazionale di Genetica Molecolare 'Romeo ed Erica Invernizzi,' Milan, Italy., Conti M; INGM-Istituto Nazionale di Genetica Molecolare 'Romeo ed Erica Invernizzi,' Milan, Italy., De Francesco R; INGM-Istituto Nazionale di Genetica Molecolare 'Romeo ed Erica Invernizzi,' Milan, Italy; National Cancer Institute Regina Elena, Via Elio Chianesi 53, 00144 Rome, Italy., Kuka M; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; Vita-Salute San Raffaele University, 20132 Milan, Italy., Ciliberto G; National Cancer Institute Regina Elena, Via Elio Chianesi 53, 00144 Rome, Italy., Castilletti C; National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149 Rome, Italy., Capobianchi MR; National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149 Rome, Italy., Ippolito G; National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149 Rome, Italy., Guidotti LG; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; Vita-Salute San Raffaele University, 20132 Milan, Italy., Rovati L; Rottapharm Biotech s.r.l., Via Valosa di Sopra 9, 20900 Monza, Italy; Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy., Iannacone M; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; Vita-Salute San Raffaele University, 20132 Milan, Italy; Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. Electronic address: iannacone.matteo@hsr.it., Aurisicchio L; Takis Biotech, Via Castel Romano 100, 00128 Rome, Italy; Evvivax Biotech, Via Castel Romano 100, 00128 Rome, Italy; Neomatrix Biotech, Via Castel Romano 100, 00128 Rome, Italy. Electronic address: aurisicchio@takisbiotech.it.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2022 Jan 05; Vol. 30 (1), pp. 311-326. Date of Electronic Publication: 2021 Sep 20.

Novel Symmetrical Benzazolyl Derivatives Endowed with Potent Anti-Heparanase Activity.

Autor: Messore A; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti , 'Sapienza' Università di Roma , Piazzale Aldo Moro 5 , I-00185 Roma , Italy., Madia VN; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti , 'Sapienza' Università di Roma , Piazzale Aldo Moro 5 , I-00185 Roma , Italy., Pescatori L; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti , 'Sapienza' Università di Roma , Piazzale Aldo Moro 5 , I-00185 Roma , Italy., Saccoliti F; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti , 'Sapienza' Università di Roma , Piazzale Aldo Moro 5 , I-00185 Roma , Italy., Tudino V; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti , 'Sapienza' Università di Roma , Piazzale Aldo Moro 5 , I-00185 Roma , Italy., De Leo A; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti , 'Sapienza' Università di Roma , Piazzale Aldo Moro 5 , I-00185 Roma , Italy., Bortolami M; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti , 'Sapienza' Università di Roma , Piazzale Aldo Moro 5 , I-00185 Roma , Italy., De Vita D; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti , 'Sapienza' Università di Roma , Piazzale Aldo Moro 5 , I-00185 Roma , Italy., Scipione L; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti , 'Sapienza' Università di Roma , Piazzale Aldo Moro 5 , I-00185 Roma , Italy., Pepi F; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti , 'Sapienza' Università di Roma , Piazzale Aldo Moro 5 , I-00185 Roma , Italy., Costi R; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti , 'Sapienza' Università di Roma , Piazzale Aldo Moro 5 , I-00185 Roma , Italy., Rivara S; Dipartimento di Scienze degli Alimenti e del Farmaco , Università degli Studi di Parma , Parco Area delle Scienze 27/A , I- 43124 Parma , Italy., Scalvini L; Dipartimento di Scienze degli Alimenti e del Farmaco , Università degli Studi di Parma , Parco Area delle Scienze 27/A , I- 43124 Parma , Italy., Mor M; Dipartimento di Scienze degli Alimenti e del Farmaco , Università degli Studi di Parma , Parco Area delle Scienze 27/A , I- 43124 Parma , Italy., Ferrara FF; Takis S.R.L. , Via Castel Romano 100 , I-00128 Roma , Italy., Pavoni E; Takis S.R.L. , Via Castel Romano 100 , I-00128 Roma , Italy., Roscilli G; Takis S.R.L. , Via Castel Romano 100 , I-00128 Roma , Italy., Cassinelli G; Dipartimento di Ricerca Applicata e Sviluppo Tecnologico, Unità di Farmacologia Molecolare , Fondazione IRCCS Istituto Nazionale dei Tumori , via Amadeo 42 , I-20133 Milano , Italy., Milazzo FM; R&D Alfasigma S.p.A. , Via Pontina Km 30,400 , Pomezia, I-00071 Roma , Italy., Battistuzzi G; R&D Alfasigma S.p.A. , Via Pontina Km 30,400 , Pomezia, I-00071 Roma , Italy., Di Santo R; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti , 'Sapienza' Università di Roma , Piazzale Aldo Moro 5 , I-00185 Roma , Italy., Giannini G; R&D Alfasigma S.p.A. , Via Pontina Km 30,400 , Pomezia, I-00071 Roma , Italy.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Dec 13; Vol. 61 (23), pp. 10834-10859. Date of Electronic Publication: 2018 Nov 29.

MicroRNA-128-3p-mediated depletion of Drosha promotes lung cancer cell migration.

Autor: Frixa T; Oncogenomic and Epigenetic Unit, Italian National Cancer Institute 'Regina Elena', Rome, Italy., Sacconi A; Oncogenomic and Epigenetic Unit, Italian National Cancer Institute 'Regina Elena', Rome, Italy., Cioce M; Oncogenomic and Epigenetic Unit, Italian National Cancer Institute 'Regina Elena', Rome, Italy., Roscilli G; Takis s.r.l., via Castel Romano, Rome, Italy., Ferrara FF; Takis s.r.l., via Castel Romano, Rome, Italy., Aurisicchio L; Takis s.r.l., via Castel Romano, Rome, Italy., Pulito C; Molecular Chemoprevention Group, Italian National Cancer Institute 'Regina Elena', Rome, Italy., Telera S; Department of Neurosurgery, Italian National Cancer Institute 'Regina Elena', Rome, Italy., Carosi M; Department of Pathology, Italian National Cancer Institute 'Regina Elena', Rome, Italy., Muti P; Department of Oncology, Juravinski Cancer Center, McMaster University Hamilton, Hamilton, ON Ontario, Canada., Strano S; Molecular Chemoprevention Group, Italian National Cancer Institute 'Regina Elena', Rome, Italy.; Department of Oncology, Juravinski Cancer Center, McMaster University Hamilton, Hamilton, ON Ontario, Canada., Donzelli S; Oncogenomic and Epigenetic Unit, Italian National Cancer Institute 'Regina Elena', Rome, Italy., Blandino G; Oncogenomic and Epigenetic Unit, Italian National Cancer Institute 'Regina Elena', Rome, Italy.; Department of Oncology, Juravinski Cancer Center, McMaster University Hamilton, Hamilton, ON Ontario, Canada.

Publikováno v: Carcinogenesis [Carcinogenesis] 2018 Feb 09; Vol. 39 (2), pp. 293-304.