Zobrazeno 1 - 10
of 1 251
pro vyhledávání: '"FERNANDO J. MARTINEZ"'
Autor:
Shrestha Ghosh, Mileena T. Nguyen, Ha Eun Choi, Maximilian Stahl, Annemarie Luise Kühn, Sandra Van der Auwera, Hans J. Grabe, Henry Völzke, Georg Homuth, Samuel A. Myers, Cory M. Hogaboam, Imre Noth, Fernando J. Martinez, Gregory A. Petsko, Laurie H. Glimcher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Telomere shortening is a prominent hallmark of aging and is emerging as a characteristic feature of Myelodysplastic Syndromes (MDS) and Idiopathic Pulmonary Fibrosis (IPF). Optimal telomerase activity prevents progressive shortening of telom
Externí odkaz:
https://doaj.org/article/acac83437afc458ea79c24761644c96b
Autor:
Klaus F. Rabe, Fernando J. Martinez, Surya P. Bhatt, Tomotaka Kawayama, Borja G. Cosio, Robert M. Mroz, Maarten M. Boomsma, Helene Goulaouic, Michael C. Nivens, Michel Djandji, Xavier Soler, Ying Liu, Matthew P. Kosloski, Christine R. Xu, Nikhil Amin, Heribert Staudinger, David J. Lederer, Raolat M. Abdulai
Publikováno v:
ERJ Open Research, Vol 10, Iss 5 (2024)
Background Accumulating data implicate interleukin (IL)-33, a proinflammatory cytokine released locally upon epithelial cell damage, in the pathogenesis of COPD. In a phase 2 study, itepekimab, a human monoclonal antibody against IL-33, reduced exace
Externí odkaz:
https://doaj.org/article/3bd4edef6ab44bf1a5e1e7bec238bd0c
Autor:
Kerri I. Aronson, Mangala Rajan, Janani Varadarajan, Tessy K. Paul, Jeffrey J. Swigris, Jamuna K. Krishnan, Robert J. Kaner, Fernando J. Martinez, Monika M. Safford, Laura C. Pinheiro
Publikováno v:
ERJ Open Research, Vol 10, Iss 4 (2024)
Rationale and objective Disease-specific health-related quality of life (HRQOL) instruments enable us to capture domains that are most relevant to specific patient populations and are useful when a more individualised approach to patient assessment i
Externí odkaz:
https://doaj.org/article/569a28d2189c441da7a1ea7ece7d9b89
Autor:
Alexander J. Bell, Ravi Pal, Wassim W. Labaki, Benjamin A. Hoff, Jennifer M. Wang, Susan Murray, Ella A. Kazerooni, Stefanie Galban, David A. Lynch, Stephen M. Humphries, Fernando J. Martinez, Charles R. Hatt, MeiLan K. Han, Sundaresh Ram, Craig J. Galban
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Small airways disease (SAD) is a major cause of airflow obstruction in COPD patients and has been identified as a precursor to emphysema. Although the amount of SAD in the lungs can be quantified using our Parametric Response Mapp
Externí odkaz:
https://doaj.org/article/7ce7ea7e78a94cbabe467d5df815a259
Autor:
Katarina M. DiLillo, Katy C. Norman, Christine M. Freeman, Stephanie A. Christenson, Neil E. Alexis, Wayne H. Anderson, Igor Z. Barjaktarevic, R. Graham Barr, Alejandro P. Comellas, Eugene R. Bleecker, Richard C. Boucher, David J. Couper, Gerard J. Criner, Claire M. Doerschuk, J. Michael Wells, MeiLan K. Han, Eric A. Hoffman, Nadia N. Hansel, Annette T. Hastie, Robert J. Kaner, Jerry A. Krishnan, Wassim W. Labaki, Fernando J. Martinez, Deborah A. Meyers, Wanda K. O’Neal, Victor E. Ortega, Robert Paine, Stephen P. Peters, Prescott G. Woodruff, Christopher B. Cooper, Russell P. Bowler, Jeffrey L. Curtis, Kelly B. Arnold, SPIROMICS investigators
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Accelerated progression of chronic obstructive pulmonary disease (COPD) is associated with increased risks of hospitalization and death. Prognostic insights into mechanisms and markers of progression could facilitate development of disease-m
Externí odkaz:
https://doaj.org/article/44f990fcab4543089c5321fad16440df
Autor:
Ayodeji Adegunsoye, Chad A. Newton, Justin M. Oldham, Brett Ley, Cathryn T. Lee, Angela L. Linderholm, Jonathan H. Chung, Nicole Garcia, Da Zhang, Rekha Vij, Robert Guzy, Renea Jablonski, Remzi Bag, Rebecca S. Voogt, Shwu-Fan Ma, Anne I. Sperling, Ganesh Raghu, Fernando J. Martinez, Mary E. Strek, Paul J. Wolters, Christine Kim Garcia, Brandon L. Pierce, Imre Noth
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
The association of telomere length with age and mortality across racially diverse pulmonary fibrosis populations is unknown. Here, the authors show that leukocyte telomere length associates with chronologic age and is predictive of mortality in pulmo
Externí odkaz:
https://doaj.org/article/0bc191d2efb44548bed2e6c7dc646b0c
Autor:
Franck F. Rahaghi, Vivien M. Hsu, Robert J. Kaner, Maureen D. Mayes, Ivan O. Rosas, Rajan Saggar, Virginia D. Steen, Mary E. Strek, Elana J. Bernstein, Nitin Bhatt, Flavia V. Castelino, Lorinda Chung, Robyn T. Domsic, Kevin R. Flaherty, Nishant Gupta, Bashar Kahaleh, Fernando J. Martinez, Lee E. Morrow, Teng Moua, Nina Patel, Oksana A. Shlobin, Brian D. Southern, Elizabeth R. Volkmann, Dinesh Khanna
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Systemic sclerosis (SSc) is a rare, complex, connective tissue disorder. Interstitial lung disease (ILD) is common in SSc, occurring in 35–52% of patients and accounting for 20–40% of mortality. Evolution of therapeutic option
Externí odkaz:
https://doaj.org/article/f0f7c08666254d739a6ca421ab557bf3
Autor:
Anna J. Podolanczuk, John S. Kim, Christopher B. Cooper, Joseph A. Lasky, Susan Murray, Justin M. Oldham, Ganesh Raghu, Kevin R. Flaherty, Cathie Spino, Imre Noth, Fernando J. Martinez, for the PRECISIONS Study Team
Publikováno v:
BMC Pulmonary Medicine, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with few treatment options. N-acetylcysteine (NAC) is a well-tolerated, inexpensive treatment with antioxidant and anti-fibrotic properties. The National Heart, Lun
Externí odkaz:
https://doaj.org/article/ef83599c7dc347129a8e38e69b384b6c
Autor:
Vickram Tejwani, Han Woo, Chen Liu, Anna K. Tillery, Amanda J. Gassett, Richard E. Kanner, Eric A. Hoffman, Fernando J. Martinez, Prescott G. Woodruff, R. Graham Barr, Ashraf Fawzy, Kirsten Koehler, Jeffrey L. Curtis, Christine M. Freeman, Christopher B. Cooper, Alejandro P. Comellas, Cheryl Pirozzi, Robert Paine, Donald Tashkin, Jerry A. Krishnan, Coralynn Sack, Nirupama Putcha, Laura M. Paulin, Marina Zusman, Joel D. Kaufman, Neil E. Alexis, Nadia N. Hansel
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background Airway macrophages (AM), crucial for the immune response in chronic obstructive pulmonary disease (COPD), are exposed to environmental particulate matter (PM), which they retain in their cytoplasm as black carbon (BC). However, wh
Externí odkaz:
https://doaj.org/article/560d7cf59df54945adb8be143473ac12
Autor:
Jennifer M. Wang, Wassim W. Labaki, Susan Murray, Fernando J. Martinez, Jeffrey L. Curtis, Eric A. Hoffman, Sundaresh Ram, Alexander J. Bell, Craig J. Galban, MeiLan K. Han, Charles Hatt
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Purpose: The purpose of this study was to train and validate machine learning models for predicting rapid decline of forced expiratory volume in 1 s (FEV1) in individuals with a smoking history at-risk-for chronic obstructive pulmonary disease (COPD)
Externí odkaz:
https://doaj.org/article/3c3d23de882645ab9496817bd9920e97