Toxicological Evaluation of Anti-Scrapie Trimethoxychalcones and Oxadiazoles

Autor: CLAUDIA P. FIGUEIREDO, NATALIA C. FERREIRA, GISELLE F. PASSOS, ROBSON DA COSTA, FERNANDA S. NEVES, CLARICE S.C. MACHADO, ALESSANDRA MASCARELLO, LOUISE D. CHIARADIA-DELATORRE, PATRÍCIA D. NEUENFELDT, RICARDO J. NUNES, YRAIMA CORDEIRO

Publikováno v: Anais da Academia Brasileira de Ciências, Vol 87, Iss 2 suppl, Pp 1421-1434 (2015)

An altered form of the cellular prion protein, the PrPScor PrPRes, is implicated in the occurrence of the still untreatable transmissible spongiform encephalopathies. We have previously synthesized and characterized aromatic compounds that inhibit pr

Externí odkaz: https://doaj.org/article/7c9d0eadc0b24f0895791b4cc5cc305c

Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

Autor: Julia R Clarke, Natalia M Lyra e Silva, Claudia P Figueiredo, Rudimar L Frozza, Jose H Ledo, Danielle Beckman, Carlos K Katashima, Daniela Razolli, Bruno M Carvalho, Renata Frazão, Marina A Silveira, Felipe C Ribeiro, Theresa R Bomfim, Fernanda S Neves, William L Klein, Rodrigo Medeiros, Frank M LaFerla, Jose B Carvalheira, Mario J Saad, Douglas P Munoz, Licio A Velloso, Sergio T Ferreira, Fernanda G De Felice

Publikováno v: EMBO Molecular Medicine, Vol 7, Iss 2, Pp 190-210 (2015)

Abstract Alzheimer's disease (AD) is associated with peripheral metabolic disorders. Clinical/epidemiological data indicate increased risk of diabetes in AD patients. Here, we show that intracerebroventricular infusion of AD‐associated Aβ oligomer

Externí odkaz: https://doaj.org/article/bfe3876cdb4d49808c5c97e93ba78817

Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson's disease-like symptoms in mice

Autor: Paula S. Frost, Julia R. Clarke, Fernanda S Neves, Carolina A. Braga, Cláudia P. Figueiredo, Juliana T.S. Fortuna, Fernanda G. De Felice, Debora Foguel, Rafaella Araujo Gonçalves, Flávia Carvalho Alcantara Gomes, Matthias Gralle, Luciana Romão, Luan Pereira Diniz, Sergio T. Ferreira, Danielle Beckman, Félix Alexandre Antunes Soares, Fernanda G. Q. Barros-Aragão, Luis E. Santos, Daniele Coradini Zamberlan

Publikováno v: Behavioural brain research. 333

Parkinson's disease (PD) is characterized by motor dysfunction, which is preceded by a number of non-motor symptoms including olfactory deficits. Aggregation of α-synuclein (α-syn) gives rise to Lewy bodies in dopaminergic neurons and is thought to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405fc799d2da147d66119dbfbac27f9e
https://pubmed.ncbi.nlm.nih.gov/28668282

Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

Autor: Theresa R. Bomfim, Rodrigo Medeiros, Julia R. Clarke, Renata Frazão, Sergio T. Ferreira, Jose Henrique Ledo, Natalia M. Lyra e Silva, William L. Klein, Rudimar Luiz Frozza, Carlos K. Katashima, José B.C. Carvalheira, Frank M. LaFerla, Felipe C. Ribeiro, Fernanda G. De Felice, Fernanda S Neves, Marina A. Silveira, Cláudia P. Figueiredo, Douglas P. Munoz, Bruno M. Carvalho, Danielle Beckman, Mario J.A. Saad, Daniela S. Razolli, Licio A. Velloso

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
EMBO Molecular Medicine
Clarke, J. R; Lyra e Silva, N. M; Figueiredo, C. P; Frozza, R. L; Ledo, J. H; Beckman, D.; et al.(2015). Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation. EMBO Molecular Medicine, 7(2), 190-210. doi: 10.15252/emmm.201404183. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/2p2547j9
Clarke, JR; Lyra e Silva, NM; Figueiredo, CP; Frozza, RL; Ledo, JH; Beckman, D; et al.(2015). Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation. EMBO Molecular Medicine, 7(2), 190-210. doi: 10.15252/emmm.201404183. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/92n2z2sf

© 2015 The Authors. Published under the terms of the CC BY 4.0 license. Alzheimer's disease (AD) is associated with peripheral metabolic disorders. Clinical/epidemiological data indicate increased risk of diabetes in AD patients. Here, we show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61bf7423ff5f3132b0e69be836659912