Zobrazeno 1 - 10
of 29
pro vyhledávání: '"FELIPE C.G. REIS"'
Autor:
Jae-Su Moon, Flavia Franco da Cunha, Jin Young Huh, Alexander Yu Andreyev, Jihyung Lee, Sushil K. Mahata, Felipe C.G. Reis, Chanond A. Nasamran, Yun Sok Lee
Publikováno v:
JCI Insight, Vol 6, Iss 20 (2021)
Macrophage proinflammatory activation is an important etiologic component of the development of insulin resistance and metabolic dysfunction in obesity. However, the underlying mechanisms are not clearly understood. Here, we demonstrate that a mitoch
Externí odkaz:
https://doaj.org/article/ae17e38f7a7047aa88e356bab333a21a
Autor:
Beatriz A. Guerra, Bruna B. Brandão, Silas S. Pinto, Willian G. Salgueiro, Evandro A. De-Souza, Felipe C.G. Reis, Thiago M. Batista, Vanessa Cavalcante-Silva, Vânia D'Almeida, Beatriz A. Castilho, Everardo M. Carneiro, Adam Antebi, William T. Festuccia, Marcelo A. Mori
Publikováno v:
Molecular Metabolism, Vol 29, Iss , Pp 124-135 (2019)
Objective: Dietary restriction (DR) improves health and prolongs lifespan in part by upregulating type III endoribonuclease DICER in adipose tissue. In this study, we aimed to specifically test which missing dietary component was responsible for DICE
Externí odkaz:
https://doaj.org/article/9b5c8308281448c7a29c8f62b1b468c9
Autor:
Santosh K. Maurya, Jose L. Herrera, Sanjaya K. Sahoo, Felipe C.G. Reis, Rick B. Vega, Daniel P. Kelly, Muthu Periasamy
Publikováno v:
Cell Reports, Vol 24, Iss 11, Pp 2919-2931 (2018)
Summary: The major objective of this study was to understand the molecular basis of how sarcolipin uncoupling of SERCA regulates muscle oxidative metabolism. Using genetically engineered sarcolipin (SLN) mouse models and primary muscle cells, we demo
Externí odkaz:
https://doaj.org/article/2deffcb38bd64d47a25a8517d5d73988
Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075
Autor:
Kameswari Ananthakrishnan Manda, Yudong Ji, Zhongmou Jin, Meixiang Yang, Roi Isaac, Felipe C.G. Reis, Jerrold M. Olefsky, Zhenlong Luo, Wenxian Fu, Wei Ying, Gautam Bandyopadhyay, Hong Gao
Publikováno v:
Nature Metabolism. 3:1163-1174
In chronic obesity, hepatocytes become insulin resistant and exert important effects on systemic metabolism. Here we show that in early onset obesity (4 weeks high-fat diet), hepatocytes secrete exosomes that enhance insulin sensitivity both in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3f57a4f5b18ccc5b3d9486884448543
https://doi.org/10.1038/s42255-021-00444-1
https://doi.org/10.1038/s42255-021-00444-1
Autor:
Ya-ju Chang, Yudong Ji, Dinghong Zhang, Felipe C.G. Reis, Crystal Ly, Deepak Kumar, Wei Ying, Zhongmou Jin, Gautam Bandyopadhyay, Zhenlong Luo, Hong Gao
Publikováno v:
Gastroenterology. 160:863-874
Background & Aims Liver CRIg+ (complement receptor of the immunoglobulin superfamily) macrophages play a critical role in filtering bacteria and their products from circulation. Translocation of microbiota-derived products from an impaired gut barrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::154e378921a7d184a7a26e29bee00f9a
https://doi.org/10.1053/j.gastro.2020.10.042
https://doi.org/10.1053/j.gastro.2020.10.042
Autor:
THERESA V. ROHM, FELIPE C.G. REIS, ROI ISAAC, MILES PASZEK, GAUTAM BANDYOPADHYAY, JERROLD M. OLEFSKY
Publikováno v:
Diabetes. 71
Background: The beneficial metabolic effects of the PPARγ agonist rosiglitazone (Rosi) are associated with anti-inflammatory changes in adipose tissue macrophages (ATMs) . One study aim was to characterize the in vivo Rosi-induced phenotypic switch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef57345d697d6464948efbfa31f8f348
https://doi.org/10.2337/db22-2-or
https://doi.org/10.2337/db22-2-or
Autor:
Chanond A Nasamran, Alexander Y. Andreyev, Flavia Franco da Cunha, Jihyung Lee, Felipe C.G. Reis, Sushil K. Mahata, Jae-Su Moon, Jin Young Huh, Yun Sok Lee
Publikováno v:
JCI Insight
JCI insight, vol 6, iss 20
JCI insight, vol 6, iss 20
Macrophage proinflammatory activation is an important etiologic component of the development of insulin resistance and metabolic dysfunction in obesity. However, the underlying mechanisms are not clearly understood. Here, we demonstrate that a mitoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abd2a37c74276bf350d150206a83e5b
http://europepmc.org/articles/PMC8564915
http://europepmc.org/articles/PMC8564915
Publikováno v:
Cell metabolism, vol 33, iss 9
Cell Metab
Cell Metab
Exosomes are nanoparticles secreted by all cell types and are a large component of the broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted, exosomes gain access to the interstitial space and ultimately the circulation, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99179ef091c2ebd0623924ac9cb70da
https://escholarship.org/uc/item/5cr8h1vx
https://escholarship.org/uc/item/5cr8h1vx
Autor:
Rizaldy C. Zapata, Jachelle M. Ofrecio, Denise E. Lackey, Yun Sok Lee, Dalila El Ouarrat, Olivia Osborn, Gautam Bandyopadhyay, Felipe C.G. Reis, Roi Isaac, Da Young Oh
Publikováno v:
Scientific reports, vol 9, iss 1
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Insulin resistance is a key feature of obesity and type 2 diabetes. PU.1 is a master transcription factor predominantly expressed in macrophages but after HFD feeding PU.1 expression is also significantly increased in adipocytes. We generated adipocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9120ba092959af384bf5ccef1314fce1
https://escholarship.org/uc/item/7zk4903p
https://escholarship.org/uc/item/7zk4903p
Autor:
Gongxin Yu, Michelle B. Trevino, Daniel P. Kelly, Rick B. Vega, Paul M. Coen, Muthu Periasamy, Felipe C.G. Reis, Bret H. Goodpaster, Xianlin Han, Robert A. Standley, Xiaolei Zhang, Miao Wang
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism
Skeletal muscle atrophy is a clinically important outcome of disuse because of injury, immobilization, or bed rest. Disuse atrophy is accompanied by mitochondrial dysfunction, which likely contributes to activation of the muscle atrophy program. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3ac90c922bbd2a35be01a94dbc2ab2
https://pubmed.ncbi.nlm.nih.gov/31479303
https://pubmed.ncbi.nlm.nih.gov/31479303