Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank

Autor: B Hollis, C Chatzigeorgiou, L Southam, K Hatzikotoulas, S Kluzek, A Williams, E Zeggini, L Jostins-Dean, FE Watt

Objective Acute knee injury is associated with post-traumatic OA (PTOA). Very little is known about the genome-wide associations of PTOA when compared with idiopathic OA (iOA). Our objective was to describe the development of knee OA after knee injur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614212055f8f6fe10302630f80060d06
http://hdl.handle.net/10044/1/104501

Development of methodology to support molecular endotype discovery from synovial fluid of individuals with knee osteoarthritis: The STEpUP OA consortium.

Autor: Deng Y; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom., Perry TA; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom., Hulley P; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom., Maciewicz RA; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom., Mitchelmore J; Novartis Institutes for Biomedical Research, Basel, Switzerland., Perry D; SomaLogic, Boulder, Colorado, United States of America., Larsson S; Department of Clinical Sciences Lund, Orthopaedics, Faculty of Medicine, Lund University, Lund, Sweden., Brachat S; Novartis Institutes for Biomedical Research, Basel, Switzerland., Struglics A; Department of Clinical Sciences Lund, Orthopaedics, Faculty of Medicine, Lund University, Lund, Sweden., Appleton CT; Bone and Joint Institute, University of Western Ontario, London, Ontario, Canada., Kluzek S; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.; NIHR Nottingham Biomedical Research Centre and Versus Arthritis Sport, Exercise and Osteoarthritis Centre, University of Nottingham, Nottingham, United Kingdom., Arden NK; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.; Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, University of Oxford, Oxford, United Kingdom., Felson D; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts, United States of America., Marsden B; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Tom BDM; MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom., Bondi L; MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom., Kapoor M; Schroeder Arthritis Institute, University Health Network, Toronto, Ontario, Canada., Batchelor V; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom., Mackay-Alderson J; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom., Kumar V; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom., Lohmander LS; Department of Clinical Sciences Lund, Orthopaedics, Faculty of Medicine, Lund University, Lund, Sweden., Welting TJ; Laboratory for Experimental Orthopedics, Department of Orthopedic Surgery, Maastricht University, Maastricht, Netherlands., Walsh DA; Pain Centre Versus Arthritis, Advanced Pain Discovery Platform, and the NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom.; Sherwood Forest Hospitals NHS Foundation Trust, Sutton in Ashfield, United Kingdom., Valdes AM; Pain Centre Versus Arthritis, Advanced Pain Discovery Platform, and the NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom., Vincent TL; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom., Watt FE; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom.; Department of Immunology and Inflammation, Imperial College London, London, United Kingdom., Jostins-Dean L; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom.

Publikováno v: PloS one [PLoS One] 2024 Nov 18; Vol. 19 (11), pp. e0309677. Date of Electronic Publication: 2024 Nov 18 (Print Publication: 2024).

Pain Reduction With Oral Methotrexate in Knee Osteoarthritis : A Randomized, Placebo-Controlled Clinical Trial.

Autor: Kingsbury SR; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre, Leeds, United Kingdom (S.R.K., P.G.C.)., Tharmanathan P; York Trials Unit, Department of Health Sciences, Faculty of Science, University of York, Heslington, York, United Kingdom (P.T., A.K., C.A., M.W., S.J.R., C.H., D.J.T.)., Keding A; York Trials Unit, Department of Health Sciences, Faculty of Science, University of York, Heslington, York, United Kingdom (P.T., A.K., C.A., M.W., S.J.R., C.H., D.J.T.)., Watt FE; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Hammersmith Campus, Imperial College London, and Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and Department of Rheumatology, Oxford University Hospitals NHS Foundation Trust, and Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, Oxford, United Kingdom (F.E.W.)., Scott DL; King's College London, London, United Kingdom (D.L.S.)., Roddy E; Primary Care Centre Versus Arthritis, Keele University, and Haywood Academic Rheumatology Centre, Midlands Partnership University NHS Foundation Trust, Keele, United Kingdom (E.R.)., Birrell F; Medical Research Council-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing, Newcastle University, and Northumbria Healthcare NHS Foundation Trust, Newcastle upon Tyne, United Kingdom (F.B.)., Arden NK; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, and Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, University of Oxford, Oxford, United Kingdom (N.K.A.)., Bowes M; Imorphics, Manchester, United Kingdom (M.B.)., Arundel C; York Trials Unit, Department of Health Sciences, Faculty of Science, University of York, Heslington, York, United Kingdom (P.T., A.K., C.A., M.W., S.J.R., C.H., D.J.T.)., Watson M; York Trials Unit, Department of Health Sciences, Faculty of Science, University of York, Heslington, York, United Kingdom (P.T., A.K., C.A., M.W., S.J.R., C.H., D.J.T.)., Ronaldson SJ; York Trials Unit, Department of Health Sciences, Faculty of Science, University of York, Heslington, York, United Kingdom (P.T., A.K., C.A., M.W., S.J.R., C.H., D.J.T.)., Hewitt C; York Trials Unit, Department of Health Sciences, Faculty of Science, University of York, Heslington, York, United Kingdom (P.T., A.K., C.A., M.W., S.J.R., C.H., D.J.T.)., Doherty M; Academic Rheumatology and Pain Centre Versus Arthritis, University of Nottingham, Nottingham, United Kingdom (M.D.)., Moots RJ; Faculty of Heath Social Care and Medicine, Edge Hill University, Ormskirk, and Department of Rheumatology, Aintree University Hospital, Liverpool, United Kingdom (R.J.M.)., O'Neill TW; Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, Manchester Academic Health Science Centre, University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom (T.W.O.)., Green M; Harrogate and District NHS Foundation Trust, Harrogate, and York Teaching Hospital NHS Foundation Trust, York, United Kingdom (M.G.)., Patel G; Rheumatology Department, Ashford and St. Peter's Hospital NHS Trust, Chertsey, United Kingdom (G.P.)., Garrood T; Department of Rheumatology, Guy's and St. Thomas' NHS Trust, London, United Kingdom (T.G.)., Edwards CJ; NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom (C.J.E.)., Walmsley PJ; Department of Orthopaedics, Victoria Hospital Kirkcaldy and School of Medicine, St. Andrews University, Fife and Fife NHS Trust, Kirkcaldy, United Kingdom (P.J.W.)., Sheeran T; Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, United Kingdom (T.S.)., Torgerson DJ; York Trials Unit, Department of Health Sciences, Faculty of Science, University of York, Heslington, York, United Kingdom (P.T., A.K., C.A., M.W., S.J.R., C.H., D.J.T.)., Conaghan PG; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre, Leeds, United Kingdom (S.R.K., P.G.C.).

Publikováno v: Annals of internal medicine [Ann Intern Med] 2024 Sep; Vol. 177 (9), pp. 1145-1156. Date of Electronic Publication: 2024 Jul 30.

Toward designing human intervention studies to prevent osteoarthritis after knee injury: A report from an interdisciplinary OARSI 2023 workshop.

Autor: Whittaker JL; Department of Physical Therapy, University of British Columbia, Vancouver, Canada.; Arthritis Research Canada, Vancouver, Canada., Kalsoum R; Department of Immunology and Inflammation, Imperial College London, London, UK., Bilzon J; Department for Health, University of Bath, Bath, UK.; Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, UK., Conaghan PG; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.; NIHR Leeds Biomedical Research Centre, Leeds, UK., Crossley K; La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia., Dodge GR; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Mechano Therapeutics LLC, Philadelphia, PA, USA., Getgood A; Division of Orthopedic Surgery, Bone and Joint Institute, Fowler Kennedy Sport Medicine Clinic, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada., Li X; Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA.; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA., Losina E; Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, USA.; Department of Orthopedic Surgery, Harvard Medical School, Boston, USA., Mason DJ; Biomechanics and Bioengineering Research Centre Versus Arthritis, School of Biosciences, Cardiff University, Cardiff, UK., Pietrosimone B; Department of Exercise and Sport Science, University of North Carolina, USA., Risberg MA; Norwegian School Sport Sciences, Oslo, Norway.; Division of Orthopedic Surgery, Oslo University Hospital, Oslo, Norway., Roemer F; Department of Radiology, Universitätsklinikum Erlangen & Friedrich- Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.; Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA., Felson D; Section of Rheumatology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Culvenor AG; La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia., Meuffels D; Orthopedic and Sport Medicine Department, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Gerwin N; Novartis BioMedical Research, Basel, Switzerland., Simon LS; SDG LLC, Cambridge, MA, USA., Lohmander LS; Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden., Englund M; Department of Clinical Sciences Lund, Orthopaedics, Clinical Epidemiology Unit, Lund University, Lund, Sweden., Watt FE; Department of Immunology and Inflammation, Imperial College London, London, UK.; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, University of Oxford, UK.

Publikováno v: Osteoarthritis and cartilage open [Osteoarthr Cartil Open] 2024 Feb 23; Vol. 6 (2), pp. 100449. Date of Electronic Publication: 2024 Feb 23 (Print Publication: 2024).

Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank.

Autor: Hollis B; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, United Kingdom., Chatzigeorgiou C; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, United Kingdom., Southam L; Institute of Translational Genomics, Helmholtz, Munich, Germany., Hatzikotoulas K; Institute of Translational Genomics, Helmholtz, Munich, Germany., Kluzek S; Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, University of Nottingham, Nottingham, United Kingdom., Williams A; Fortius Clinic, London, United Kingdom., Zeggini E; Institute of Translational Genomics, Helmholtz, Munich, Germany., Jostins-Dean L; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, United Kingdom., Watt FE; Department of Immunology and Inflammation, Imperial College London, London, United Kingdom; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, United Kingdom. Electronic address: f.watt@imperial.ac.uk.

Publikováno v: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2023 Oct; Vol. 31 (10), pp. 1377-1387. Date of Electronic Publication: 2023 May 27.