Zobrazeno 1 - 10
of 462
pro vyhledávání: '"FDR, False Discovery Rate"'
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Banrida Wahlang, Monika Thapa, Michael L. Merchant, Jian Jin, Sudhir Srivastava, Josiah E. Hardesty, Russell A. Prough, Shesh N. Rai, Matthew C. Cave, Kimberly Z. Head
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3806-3819 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Dioxin-like molecules have been associated with endocrine disruption and liver disease. To better understand aryl hydrocarbon receptor (AHR) biology, metabolic phenotyping and liver proteomics were performed in mice following ligand-activation or who
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd0117be990219f236c36406e5afea7
https://doi.org/10.1016/j.apsb.2021.10.014
https://doi.org/10.1016/j.apsb.2021.10.014
Autor:
Guolong Liao, Hanqi Lei, Xiangwei Yang, Xing Fu, Fu Shi, Donggen Jiang, Haiyun Xiong, Yafei Yang, Yu-Peng Feng, Jun Pang, Bing-Biao Lin
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 4941-4953 (2021)
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 4941-4953 (2021)
Graphical abstract
MicroRNA (miRNA) deregulation plays a critical role in the heterogeneous development of prostate cancer (PCa) by tuning mRNA levels. Herein, we aimed to characterize the molecular features of PCa by clustering the miRNA-regula
MicroRNA (miRNA) deregulation plays a critical role in the heterogeneous development of prostate cancer (PCa) by tuning mRNA levels. Herein, we aimed to characterize the molecular features of PCa by clustering the miRNA-regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f138460d0ba30547d9145ec00105384e
http://europepmc.org/articles/PMC8433071
http://europepmc.org/articles/PMC8433071
Autor:
John W. Elrod, Steven R. Houser, Markus Wallner, Remus M. Berretta, Dhanendra Tomar, Anh T Huynh, Joanne F Garbincius, Deborah M Eaton, Emma K Murray, Devin W. Kolmetzky, Andrew A. Gibb
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Early cardiac mitochondrial dysfunction is mediated by transcriptional down-regulation of the mitochondrial proteome. • Comprehensive metabolic remodeling is conserved throughout HFpEF progression and includes in
Highlights • Early cardiac mitochondrial dysfunction is mediated by transcriptional down-regulation of the mitochondrial proteome. • Comprehensive metabolic remodeling is conserved throughout HFpEF progression and includes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474acd63270db1077349e2d878112f6b
https://doi.org/10.1016/j.jacbts.2021.07.004
https://doi.org/10.1016/j.jacbts.2021.07.004
Autor:
Masahiro Nishikawa, Ichiro Nakano, Afsana Islam, Yuji Watanabe, Daisuke Yamashita, Yasutsugu Takada, Satoshi Suehiro, Hideaki Watanabe, Junya Tanaka, Takeharu Kunieda, Yoshihiro Ohtsuka, Yutaro Sumida, Akihiro Umakoshi, Erika Hayase, Yusuke Nishi, Shota Ohsumi, Eika Usa, Saya Ozaki, Akihiro Inoue, Jun Kuwabara, Hajime Yano, Mohammed E. Choudhury
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 8, Pp 754-765 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Highlights • CLIC2 is highly expressed in benign, less invasive and less metastatic tumors. • Forced expression of CLIC2 prevents metastasis and invasion in animal tumor models. • CLIC2 is associated with decreased vascular permeability in tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a1857fc7fdf8e1121e51752c54bf4f
http://www.sciencedirect.com/science/article/pii/S1476558621000439
http://www.sciencedirect.com/science/article/pii/S1476558621000439
Autor:
Barbara Joanna Niklinska-Schirtz, Murugadas Anbazhagan, Anil G. Jegga, Vasantha L. Kolachala, Suresh Venkateswaran, Lee A. Denson, Raghavan Chinnadurai, Jason D. Matthews, Subra Kugathasan, Gregory Gibson, David J. Cutler, Anne Dodd, Jarod Prince
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1267-1280 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1267-1280 (2021)
Background & Aims We used patient-derived organoids (PDOs) to study the epithelial-specific transcriptional and secretome signatures of the ileum during Crohn’s disease (CD) with varying phenotypes to screen for disease profiles and potential drugg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a702e5ad7a3308d75a8e643ce59a82d6
http://europepmc.org/articles/PMC8455365
http://europepmc.org/articles/PMC8455365
Autor:
Simo V. Zhang, Gabor Bartha, Rachel Marty Pyke, Richard Chen, Sean Michael Boyle, Jason Harris, John A. West, Michael Snyder, Sejal Desai, Rena McClory, Charles Abbott, Dattatreya Mellacheruvu, Nick A. Phillips, Steven Dea
Publikováno v:
Mol Cell Proteomics
Molecular & Cellular Proteomics : MCP
Molecular & Cellular Proteomics : MCP
Major histocompatibility complex (MHC)-bound peptides that originate from tumor-specific genetic alterations, known as neoantigens, are an important class of anticancer therapeutic targets. Accurately predicting peptide presentation by MHC complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d51c6de9d4672b239c32b76dd7d0721
https://doi.org/10.1016/j.mcpro.2023.100506
https://doi.org/10.1016/j.mcpro.2023.100506
Autor:
Jun Chen, An Liu, Shuiming Xiao, Shaojing Li, Jiang Xu, Feipeng Duan, Xiaoyan Zhang, Sha Chen, Wen Zhong, Wei Sheng
Publikováno v:
Journal of Ginseng Research
Journal of Ginseng Research, Vol 45, Iss 2, Pp 334-343 (2021)
Journal of Ginseng Research, Vol 45, Iss 2, Pp 334-343 (2021)
Background: Gut microbiota mainly function in the biotransformation of primary ginsenosides into bioactive metabolites. Herein, we investigated the effects of three prebiotic fibers by targeting gut microbiota on the metabolism of ginsenoside Rb1 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88acbad90b2418a8feff719b2ea047b6
https://doi.org/10.1016/j.jgr.2020.08.001
https://doi.org/10.1016/j.jgr.2020.08.001
Autor:
GwangPyo Ko, Won Kim, Seoyeon Park, Bon Jeong Ku, Sae Kyung Joo, Hyun Ju You, Jiyeon Si, Giljae Lee, Dong Hyeon Lee
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 5920-5930 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Non-alcoholic fatty liver disease (NAFLD) is closely associated with type 2 diabetes mellitus (T2D), and these two metabolic diseases demonstrate bidirectional influences. The identification of microbiome profiles that are spe
Non-alcoholic fatty liver disease (NAFLD) is closely associated with type 2 diabetes mellitus (T2D), and these two metabolic diseases demonstrate bidirectional influences. The identification of microbiome profiles that are spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f954c67889fd6d23e7de29c2b7336727
http://www.sciencedirect.com/science/article/pii/S2001037021004542
http://www.sciencedirect.com/science/article/pii/S2001037021004542