Výsledky vyhledávání - "FDA - US Food and Drug Administration"

Approved HIV reverse transcriptase inhibitors in the past decade

Autor: Erik De Clercq, Guangdi Li, Yali Wang

Publikováno v: Acta Pharmaceutica Sinica B. 12:1567-1590

HIV reverse transcriptase (RT) inhibitors are the important components of highly active antiretroviral therapies (HAARTs) for anti-HIV treatment and pre-exposure prophylaxis in clinical practice. Many RT inhibitors and their combination regimens have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef424a5c6c813905e85108700bf093a5
https://doi.org/10.1016/j.apsb.2021.11.009

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Risk for Postmarket Black Box Warnings in FDA-Approved Monoclonal Antibodies

Autor: John B. Hagan, MD, Elizabeth Ender, MD, Rohit D. Divekar, MBBS, PhD, Thanai Pongdee, MD, Matthew A. Rank, MD

Publikováno v: Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 6, Iss 1, Pp 69-76 (2022)

Objective: To estimate the potential risk for a future postmarket black box warning (BBW) of US Food and Drug Administration (FDA)-approved monoclonal antibodies (mAbs) because of the importance for medical clinicians to understand mAb risks and bene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401b96e5615755d7c31a16937dafc148
https://doi.org/10.1016/j.mayocpiqo.2021.11.009

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In situ bone regeneration with sequential delivery of aptamer and BMP2 from an ECM-based scaffold fabricated by cryogenic free-form extrusion

Autor: Xianglin Zhang, Qi Zhang, Wenqing Tian, Chunqing Meng, Xiaodong Guo, Tingfang Sun, Keda Yu, Qiuyue Ding, Zekang Xiong, Bin Wu, Wancheng Zhang

Publikováno v: Bioactive Materials, Vol 6, Iss 11, Pp 4163-4175 (2021)
Bioactive Materials

In situ tissue engineering is a powerful strategy for the treatment of bone defects. It could overcome the limitations of traditional bone tissue engineering, which typically involves extensive cell expansion steps, low cell survival rates upon trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2598d49223c891cdcd36fd9c9afab4a6
http://www.sciencedirect.com/science/article/pii/S2452199X21001821

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In vitro and in vivo correlation for lipid-based formulations: Current status and future perspectives

Autor: Zhongjian Chen, Yi Lu, Yanping Huang, Quangang Zhu, Wei Wu, Qin Yu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2469-2487 (2021)
Acta Pharmaceutica Sinica. B

Lipid-based formulations (LBFs) have demonstrated a great potential in enhancing the oral absorption of poorly water-soluble drugs. However, construction of in vitro and in vivo correlations (IVIVCs) for LBFs is quite challenging, owing to a complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b31a53f79e1ed99a94fbe16d77554c
https://doi.org/10.1016/j.apsb.2021.03.025

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COVID-19 Gender Disparities and Mitigation Recommendations: A Narrative Review

Autor: Jennifer A. Vencill, Anjali Bhagra, Carol L. Kuhle, Natya N. Stroud, Hannah C. Nordhues

Publikováno v: Mayo Clinic Proceedings

The coronavirus disease 2019 (COVID-19) pandemic has rapidly created widespread impacts on global health and the economy. Data suggest that women are less prone to severe illness; however, sex-disaggregated data are incomplete, leaving room for misin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c01733e2d4f7d86a2a2e4ef79f918b8
https://doi.org/10.1016/j.mayocp.2021.04.009

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Enhancement of peripheral seal of medical face masks using a 3-dimensional–printed custom frame

Autor: Robert Handysides, Holli Riter, Eun-Hwi Cho, Yang Li, Montry S. Suprono, Udochukwu Oyoyo, Alisa Wilson, Abu Ahmed, Zhe Zhong, Roberto Savignano, Jessica Kim, Paul Richardson, Rebecca Reece, Joseph Caruso

Publikováno v: Journal of the American Dental Association (1939)

BACKGROUND: During the COVID-19 pandemic, American Society for Testing and Materials level 3 and level 2 medical face masks (MFMs) have been used for most health care workers and even for the first responders owing to a shortage of N95 respirators. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19444619e4d72fceaed361c19fd29f07
https://doi.org/10.1016/j.adaj.2021.03.011

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Hepatotoxicity reports in the FDA adverse event reporting system database: A comparison of drugs that cause injury via mitochondrial or other mechanisms

Autor: Stephen Kogut, Payal Rana, Xuerong Wen, Michael D. Aleo

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3857-3868 (2021)

Drug-induced liver injury (DILI) is a leading reason for preclinical safety attrition and post-market drug withdrawals. Drug-induced mitochondrial toxicity has been shown to play an essential role in various forms of DILI, especially in idiosyncratic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c47c4526f9d320b7aaf01e5384f32d0
http://europepmc.org/articles/PMC8727782

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Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines

Autor: Yi Guo, Mingshi Yang, Li Zhang, Changzhi Shi, Dongmei Cun, Hriday Bera

Publikováno v: Acta Pharmaceutica Sinica. B
Guo, Y, Bera, H, Shi, C, Zhang, L, Cun, D & Yang, M 2021, ' Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines ', Acta Pharmaceutica Sinica B, vol. 11, no. 8, pp. 2565-2584 . https://doi.org/10.1016/j.apsb.2021.05.015
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2565-2584 (2021)

Pulmonary administration route has been extensively exploited for the treatment of local lung diseases such as asthma, chronic obstructive pulmonary diseases and respiratory infections, and systemic diseases such as diabetes. Most inhaled medicines c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ad93be5bd1dd39fb79dc4d37488c35
http://europepmc.org/articles/PMC8424368

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Endoscopic Lung Volume Reduction: Review of the EMPROVE and LIBERATE trials

Autor: Khaled M. Nada, Shawn P.E. Nishi

Publikováno v: Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 5, Iss 1, Pp 177-186 (2021)
Mayo Clinic Proceedings: Innovations, Quality & Outcomes

Endoscopic lung volume reduction is now included in the guidelines for treatment in severe chronic obstructive pulmonary disease. Since December 2018, 2 valve systems have been approved by the US Food and Drug Administration (FDA). To date, there is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a9eef681260f857a5e2684bb163883
http://www.sciencedirect.com/science/article/pii/S2542454820301922

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