Zobrazeno 1 - 10
of 27
pro vyhledávání: '"FC Leonardo"'
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 46, Iss , Pp S44-S45 (2024)
Recent evidence has demonstrated that the gut microbiota plays an important role in the pathophysiology of sickle cell disease (SCD). Enterocyte damage, increased permeability and intestinal dysbiosis may be directly involved in modulating inflammato
Externí odkaz:
https://doaj.org/article/63e25845fbef4a8ea88e27403e0ab400
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 46, Iss , Pp S55-S56 (2024)
Introduction: Sickle cell anemia (SCA) is a hereditary condition characterized by morphological changes in erythrocytes, which increase their fragility and susceptibility to rupture, releasing intracellular components, including the heme molecule. Re
Externí odkaz:
https://doaj.org/article/b4ab26b1c37c4cbc82084fff3b4b8c4b
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 46, Iss , Pp S59- (2024)
Introduction: Intravascular hemolysis (IVH) results in the release of damage-associated molecular patterns (DAMPs) into the circulation, particularly hemoglobin (Hb) and heme, which can trigger NLRP3 inflammasome activation and a sterile inflammatory
Externí odkaz:
https://doaj.org/article/f614eccc80164f91bb728c9a407d68c4
Autor:
LFS Gushiken, SL Linguet, EMF Gotardo, PL Brito, FC Leonardo, CLV Kim, S Laurance, B Koehl, FF Costa, N Conran
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 46, Iss , Pp S99-S100 (2024)
Introduction: Sickle cell disease (SCD), the most common inherited hemoglobinopathy worldwide, results in the production of abnormal hemoglobin S. Polymerization of this hemoglobin causes red blood cell sickling and pathophysiological consequences. V
Externí odkaz:
https://doaj.org/article/62e5740a40504b8f93dac87b926fde3a
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 45, Iss , Pp S43-S44 (2023)
Sickle cell disease (SCD) is caused by the production of abnormal hemoglobin S, whose polymerization (induced by deoxygenation) results in sickling of erythrocytes and numerous pathophysiological consequences, including painful vaso-occlusive episode
Externí odkaz:
https://doaj.org/article/2b709b78e9be41ee875562dab3e6f8ee
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 45, Iss , Pp S44- (2023)
Several diseases and pathological events incur intravascular hemolysis (IVH), a pathophysiological mechanism characterized by the destruction of red blood cells and the release of hemoglobin (Hb) and heme into the circulation. Hemolytic diseases, suc
Externí odkaz:
https://doaj.org/article/01a4b3129af8471d9579ee01069f3eb4
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 45, Iss , Pp S46- (2023)
Sickle cell anemia (SCA) is an inherited disorder caused by a mutation in the gene encoding β-globin. This mutation brings about alterations in the hemoglobin molecule, resulting in abnormal red blood cell (RBC) properties, shape, and subsequent des
Externí odkaz:
https://doaj.org/article/30d756765507451bbb9b55b79a91308e
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 45, Iss , Pp S64-S65 (2023)
As doenças hemolíticas, como a anemia falciforme (AF), constituem um grupo de condições caracterizadas pela destruição prematura das hemácias (hemólise), que pode ocorrer ainda no interior dos vasos sanguíneos (intravascular; HI) ou no espa
Externí odkaz:
https://doaj.org/article/178101f56c0e45a7a16f1a7185128e25
Autor:
Gotardo ÉMF; Hematology Center, University of Campinas - UNICAMP, Campinas - São Paulo., Torres LS; Hematology Center, University of Campinas - UNICAMP, Campinas - São Paulo, Brazil; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York, NY 10461., Zaidan BC; Federal University of Triângulo Mineiro, UFTM, Minas Gerais., Gushiken LFS; Hematology Center, University of Campinas - UNICAMP, Campinas - São Paulo., Brito PL; Hematology Center, University of Campinas - UNICAMP, Campinas - São Paulo., Leonardo FC; Hematology Center, University of Campinas - UNICAMP, Campinas - São Paulo., Pellizzon CH; São Paulo State University (UNESP), Institute of Biosciences, Botucatu., Millholland J; Novartis Precision Medicine, Cambridge, MA., Agoulnik S; Novartis Precision Medicine, Cambridge, MA, USA (former affiliation)., Kovarik J; Novartis Biomedical Research, Novartis Campus, CH-4056 Basel, Switzerland., Costa FF; Hematology Center, University of Campinas - UNICAMP, Campinas - São Paulo., Conran N; Hematology Center, University of Campinas - UNICAMP, Campinas - São Paulo. conran@unicamp.br.
Publikováno v:
Haematologica [Haematologica] 2024 Nov 21. Date of Electronic Publication: 2024 Nov 21.
Autor:
Nader E; Laboratory LIBM EA7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France., Conran N; Hematology and Transfusion Center, University of Campinas, Campinas, Brazil., Leonardo FC; Hematology and Transfusion Center, University of Campinas, Campinas, Brazil., Hatem A; Sorbonne Université, CNRS, UMR 8227 LBI2M, Station Biologique de Roscoff SBR, Roscoff, France., Boisson C; Laboratory LIBM EA7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France.; Service de Biochimie et Biologie Moléculaire, Laboratoire de Biologie Médicale Multi-site, Hospices Civils de Lyon, Lyon, France., Carin R; Laboratory LIBM EA7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France., Renoux C; Laboratory LIBM EA7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France.; Service de Biochimie et Biologie Moléculaire, Laboratoire de Biologie Médicale Multi-site, Hospices Civils de Lyon, Lyon, France., Costa FF; Hematology and Transfusion Center, University of Campinas, Campinas, Brazil., Joly P; Laboratory LIBM EA7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France.; Service de Biochimie et Biologie Moléculaire, Laboratoire de Biologie Médicale Multi-site, Hospices Civils de Lyon, Lyon, France., Brito PL; Hematology and Transfusion Center, University of Campinas, Campinas, Brazil., Esperti S; Laboratory LIBM EA7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France.; Erytech Pharma, Lyon, France., Bernard J; Service de Biochimie et Biologie Moléculaire, Laboratoire de Biologie Médicale Multi-site, Hospices Civils de Lyon, Lyon, France., Gauthier A; Laboratory LIBM EA7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France.; Institut d'Hématologique et d'Oncologique Pédiatrique, Hospices Civils de Lyon, Lyon, France., Poutrel S; Laboratory LIBM EA7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France.; Service de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France., Bertrand Y; Institut d'Hématologique et d'Oncologique Pédiatrique, Hospices Civils de Lyon, Lyon, France., Garcia C; Service de Biochimie et Biologie Moléculaire, Laboratoire de Biologie Médicale Multi-site, Hospices Civils de Lyon, Lyon, France., Saad STO; Hematology and Transfusion Center, University of Campinas, Campinas, Brazil., Egée S; Sorbonne Université, CNRS, UMR 8227 LBI2M, Station Biologique de Roscoff SBR, Roscoff, France., Connes P; Laboratory LIBM EA7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France.
Publikováno v:
British journal of haematology [Br J Haematol] 2023 Aug; Vol. 202 (3), pp. 657-668. Date of Electronic Publication: 2023 Apr 03.