Zobrazeno 1 - 10
of 1 338
pro vyhledávání: '"FBXW7"'
Publikováno v:
Kouqiang yixue, Vol 44, Iss 6, Pp 426-432 (2024)
Objective To explore the effect of FBXW7 on ferroptosis in head and neck squamous cell carcinoma. Methods Head and neck squamous cell lines HN4 and HN6 were cultured in vitro. FBXW7 and SOX2 overexpression plasmids were constructed, and the plasmids
Externí odkaz:
https://doaj.org/article/50f74f58eb0b4af2a9a38b678d288bd5
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Objective: To investigate a case of neurodevelopmental disorder caused by mutation of FBXW7.Methods: Clinical data were collected from the patient, trio-WES (whole-exome sequencing) was performed on the patient and his parents (trio), and the results
Externí odkaz:
https://doaj.org/article/c3727d7b114b421eb12aff8138841bf9
Autor:
Xiaoyu Jiang, Yuli Wang, Lulu Guo, Yige Wang, Tianshu Miao, Lijuan Ma, Qin Wei, Xiaoyan Lin, Jian-Hua Mao, Pengju Zhang
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Increasing evidence shows the oncogenic function of FAM83D in human cancer, but how FAM83D exerts its oncogenic function remains largely unclear. Here, we investigated the importance of FAM83D/FBXW7 interaction in breast cancer (BC). We syst
Externí odkaz:
https://doaj.org/article/9d460fe938b64bf0980a11228514b9d1
Autor:
Tze‐Sian Chan, Li‐Hsin Cheng, Chung‐Chi Hsu, Pei‐Ming Yang, Tai‐Yan Liao, Hsiao‐Yen Hsieh, Pei‐Chun Lin, Wei‐Chun HuangFu, Chih‐Pin Chuu, Kelvin K. Tsai
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 562-579 (2024)
Notch signaling is aberrantly activated in approximately 30% of hepatocellular carcinoma (HCC), significantly contributing to tumorigenesis and disease progression. Expression of the major Notch receptor, NOTCH1, is upregulated in HCC cells and corre
Externí odkaz:
https://doaj.org/article/98d41b996f2a46b5a4a99daf235a8532
Autor:
Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Publikováno v:
Molecular Oncology, Vol 18, Iss 2, Pp 369-385 (2024)
The F‐box and WD repeat domain containing 7 (FBXW7) tumour suppressor gene encodes a substrate‐recognition subunit of Skp, cullin, F‐box (SCF)‐containing complexes. The tumour‐suppressive role of FBXW7 is ascribed to its ability to drive ub
Externí odkaz:
https://doaj.org/article/394126b61bef4541813ab49cbc06b55c
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Cancer stem cells (CSCs) are a small population of cells in tumor tissues that can drive tumor initiation and promote tumor progression. A small number of previous studies indirectly mentioned the role of F-box and WD repeat domai
Externí odkaz:
https://doaj.org/article/ae90f33abde7497fa24bee5d97c78cad
Autor:
Hafeez Abiola Afolabi, Salzihan Md Salleh, Zaidi Zakaria, Ch'ng Ewe Seng, Norasikin Mohd Nafi, Ahmad Aizat Bin AbdulAziz, Yusuf Wada, Ahmad Adebayo Irekeola, Sameer Badri Al-Ml-hanna, Ali Mussa
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e31471- (2024)
FBXW7 is a tumour suppressor gene that functions as E3-ubiquitin-ligase, targeting numerous oncoproteins for degradation, i.e., Cyclin-E, c-Myc, and Notch. FBXW7 performs a pivotal role in regulating cell cycle progression. FBXW7 mutation is frequent
Externí odkaz:
https://doaj.org/article/152ba4da2de445d0b8a37a9073c3d246
Publikováno v:
International Dental Journal, Vol 73, Iss 5, Pp 620-627 (2023)
ABSTRACT: Background: About one-third of patients with oral squamous cell carcinoma (OSCC) have a risk of occurrence and chemoresistance, making survival rates abysmal. We aim to evaluate the role of F-box/WD repeat-containing protein 7 (FBXW7) to fu
Externí odkaz:
https://doaj.org/article/ddcd6682d8224ebb832edce6d4ed908e
Autor:
Tian Zhou, Ning Ma, Yong-lin Zhang, Xing-hong Chen, Xue Luo, Mai Zhang, Qing-jun Gao, Dai-wei Zhao
Publikováno v:
Heliyon, Vol 10, Iss 2, Pp e23875- (2024)
Objective: In recent decades, thyroid cancer (TC) has exhibited a rising incidence pattern. Elevated levels of the transcription factor FOXP4 have been strongly linked to the progression of diverse tumors; nevertheless, its specific role in thyroid c
Externí odkaz:
https://doaj.org/article/3305d8569b464d7f9892d4e32723cce2
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-18 (2023)
Abstract Breast cancer is one of the frequent tumors that seriously endanger the physical and mental well-being in women. F-box and WD repeat domain-containing 7 (FBXW7) is a neoplastic repressor. Serving as a substrate recognition element for ubiqui
Externí odkaz:
https://doaj.org/article/50d4e153c4e342b5b0c774dd4a9e9f1d