Zobrazeno 1 - 10
of 755
pro vyhledávání: '"FBW7"'
Autor:
Jiaxin Liu, Lingyun Wei, Qing Miao, Sutong Zhan, Peilin Chen, Wei Liu, Liang Cao, Dong Wang, Hongbing Liu, Jie Yin, Yong Song, Mingxiang Ye, Tangfeng Lv
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Background Overcoming resistance to Osimertinib in epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) is clinically challenging because the underlying mechanisms are not fully understood. The murine double minu
Externí odkaz:
https://doaj.org/article/31df906818f147a696a9991a2c2ff3a1
Autor:
Zhiyuan Zhou, Bin Zhang, Yue Deng, Suke Deng, Jie Li, Wenwen Wei, Yijun Wang, Jiacheng Wang, Zishan Feng, Mengjie Che, Xiao Yang, Jingshu Meng, Yan Li, Yan Hu, Yajie Sun, Lu Wen, Fang Huang, Yuhan Sheng, Chao Wan, Kunyu Yang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-18 (2024)
Abstract Background The development of radioresistance seriously hinders the efficacy of radiotherapy in lung cancer. However, the underlying mechanisms by which radioresistance occurs are still incompletely understood. The N6-Methyladenosine (m6A) m
Externí odkaz:
https://doaj.org/article/b0ce5fb8b1ad450b8dce29df95647507
Autor:
JIA Yuming, YE Zeng, DENG Yanli, LI Shengchao, ZHANG Zhilei, WANG Chao, XU Xiaowu, QIN Yi, PENG Li
Publikováno v:
Zhongguo aizheng zazhi, Vol 33, Iss 10, Pp 889-897 (2023)
Background and purpose: Pancreatic cancer is a highly malignant disease. Most patients are in advanced stage upon diagnosis. Systemic chemotherapy is an important treatment method, but the chemotherapy drug resistance to tumors brings many problems t
Externí odkaz:
https://doaj.org/article/4decff585caf4d13bb77d44fdfecd6e1
Publikováno v:
Immunity, Inflammation and Disease, Vol 11, Iss 9, Pp n/a-n/a (2023)
Abstract Osteoarthritis (OA) is a prevalent and distressing chronic degenerative joint disorder characterized by damaged articular cartilage and inflamed joints. Among risk factors, obesity has emerged as the second‐leading contributor to OA after
Externí odkaz:
https://doaj.org/article/7ff94250d31243d29628e8079d8e22f3
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-15 (2022)
Abstract Background The existence of breast cancer stem cells (BCSCs) causes tumor relapses, metastasis and resistance to conventional therapy in breast cancer. NDR1 kinase, a component of the Hippo pathway, plays important roles in multiple biologic
Externí odkaz:
https://doaj.org/article/070c5b76b0304035bba0afa4fab29abb
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-26 (2022)
Abstract FBXW7 (F-Box and WD Repeat Domain Containing 7) (also referred to as FBW7 or hCDC4) is a component of the Skp1-Cdc53 / Cullin-F-box-protein complex (SCF/β-TrCP). As a member of the F-box protein family, FBXW7 serves a role in phosphorylatio
Externí odkaz:
https://doaj.org/article/1f52b2b04d9f49938464e212754e3bcd
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-18 (2022)
Abstract Background Tyrosine kinase inhibitors (TKIs) alone and in combination with immune checkpoint inhibitors (ICIs) have been shown to be beneficial for the survival of metastatic renal cell carcinoma (mRCC) patients, but resistance to targeted t
Externí odkaz:
https://doaj.org/article/64e52bdac06e4484a192da6aae938fa3
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The ubiquitin-proteasome system (UPS) is involved in various aspects of cell processes, including cell proliferation, differentiation, and cell cycle progression. F-box and WD repeat domain-containing protein 7 (FBW7), as a key component of UPS prote
Externí odkaz:
https://doaj.org/article/89b2ffbda5d348cd853e271266272ba3