Výsledky vyhledávání - "FASN inhibitors"

Akademický článek

The Pharmacological or Genetic Blockade of Endogenous De Novo Fatty Acid Synthesis Does Not Increase the Uptake of Exogenous Lipids in Ovarian Cancer Cells

Autor: Thomas W. Grunt, Lisa Lemberger, Ramón Colomer, María Luz López−Rodríguez, Renate Wagner

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Ovarian cancer(OC) is a serious threat to women worldwide. Peritoneal dissemination, ascites and omental metastasis are typical features for disease progression, which occurs in a micro-environment that is rich in high-energy lipids. OC cells require

Externí odkaz: https://doaj.org/article/effcb9a0bcc1421ebfa5a7506b05758f

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Akademický článek

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Pharmacological fatty acid synthase inhibitors differently affect the malignant phenotype of oral cancer cells

Autor: Willian Peter Boelcke, Isadora Ferrari Teixeira, Iara Gonçalves Aquino, Amanda Ramos Mazzaro, Florence Juana Maria Cuadra-Zelaya, Ana Paula de Souza, Tuula Salo, Ricardo Della Coletta, Edgard Graner, Débora Campanella Bastos

Objective: Fatty acid synthase levels are associated with aggressiveness, prognosis, and risk of metastasis in oral squamous cell carcinomas. This enzyme contains seven catalytic domains and its inhibition by synthetic or natural drugs has antineopla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e37a1cd38ae397b6da4b2b1d5da5019
http://hdl.handle.net/10138/352827

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Akademický článek

(−)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer

Autor: Joan Crous-Masó, Sònia Palomeras, Joana Relat, Cristina Camó, Úrsula Martínez-Garza, Marta Planas, Lidia Feliu, Teresa Puig

Publikováno v: Molecules, Vol 23, Iss 5, p 1160 (2018)

(−)-Epigallocatechin 3-gallate (EGCG) is a natural polyphenol from green tea with reported anticancer activity and capacity to inhibit the lipogenic enzyme fatty acid synthase (FASN), which is overexpressed in several human carcinomas. To improve t

Externí odkaz: https://doaj.org/article/47da1200e79b4a37938d1d194c1eb1e1

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Pharmacological fatty acid synthase inhibitors differently affect the malignant phenotype of oral cancer cells

Autor: Boelcke, W. P. (Willian Peter), Teixeira, I. F. (Isadora Ferrari), Aquino, I. G. (Iara Gonçalves), Mazzaro, A. R. (Amanda Ramos), Cuadra-Zelaya, F. J. (Florence Juana Maria), de Souza, A. P. (Ana Paula), Salo, T. (Tuula), Della Coletta, R. (Ricardo), Graner, E. (Edgard), Bastos, D. C. (Débora Campanella)

Objectives: Fatty acid synthase levels are associated with aggressiveness, prognosis, and risk of metastasis in oral squamous cell carcinomas. This enzyme contains seven catalytic domains and its inhibition by synthetic or natural drugs has antineopl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::efde8a797eef86cbda1c32524122394e
http://urn.fi/urn:nbn:fi-fe2022121972526

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Akademický článek

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Fatty Acid Synthase Inhibitor G28 Shows Anticancer Activity in EGFR Tyrosine Kinase Inhibitor Resistant Lung Adenocarcinoma Models

Autor: Santiago Ruiz-Martínez, Teresa Puig, Marta Planas, Lidia Feliu, Emma Polonio-Alcalá, Joaquim Ciurana, Sònia Palomeras, Joana Relat, Daniel Torres-Oteros

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Cancers
Cancers, 2020, vol. 12, núm. 5, p. 1283
Articles publicats (D-CM)
DUGiDocs – Universitat de Girona
instname
Cancers, Vol 12, Iss 1283, p 1283 (2020)
Volume 12
Issue 5

Epidermal growth factor receptor (EGFR) tyrosine kinases inhibitors (TKIs) are effective therapies for non-small cell lung cancer (NSCLC) patients whose tumors harbor an EGFR activating mutation. However, this treatment is not curative due to primary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab30660eebdabfa5dea744b7c848113
http://hdl.handle.net/2445/174882

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Akademický článek

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(−)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer

Autor: Lidia Feliu, Úrsula Martínez-Garza, Marta Planas, Cristina Camó, Teresa Puig, Sònia Palomeras, Joan Crous-Masó, Joana Relat

Publikováno v: Molecules, Vol 23, Iss 5, p 1160 (2018)
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Molecules; Volume 23; Issue 5; Pages: 1160
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, 2018, vol. 23, núm. 5, p.1160
Articles publicats (D-CM)
DUGiDocs – Universitat de Girona

(􀀀)-Epigallocatechin 3-gallate (EGCG) is a natural polyphenol from green tea with reported anticancer activity and capacity to inhibit the lipogenic enzyme fatty acid synthase (FASN), which is overexpressed in several human carcinomas. To improve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6eed462bb169dd591890a9faa66ca55
http://www.mdpi.com/1420-3049/23/5/1160

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