Zobrazeno 1 - 10
of 66
pro vyhledávání: '"FASN, fatty acid synthase"'
Autor:
Qiao Xiong, Dechao Feng, Ziwei Wang, Yidie Ying, Chuanliang Xu, Qiang Wei, Shuxiong Zeng, Lu Yang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Fatty acid metabolism (FAM) genes are potentially useful for predicting prognosis and immunotherapy response in bladder cancer (BC). To examine this, we constructed a prognostic model and identified key FAM genes in BC. Using transcriptional expressi
Externí odkaz:
https://doaj.org/article/9b58949eb3d0445e9ac86362dbc72624
Autor:
David A. Frank, Isidora Tošić
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1167-1178 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1167-1178 (2021)
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is activated constitutively in a wide array of human cancers. It is an appealing molecular target for novel therapy as it directly regulates expression of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fc1e221705a2edcb47149735290583
http://europepmc.org/articles/PMC8569436
http://europepmc.org/articles/PMC8569436
Publikováno v:
JACC: Basic to Translational Science
Highlights • Cancer cells can promote metabolic remodeling in the heart. • Metabolic changes provide opportunities for novel treatment strategies to prevent heart failure and monitor disease progression through new imaging techniques. • Transla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68748cb7277a02618d388f95ef5a04f2
http://europepmc.org/articles/PMC8385559
http://europepmc.org/articles/PMC8385559
Autor:
Menghao Huang, Kushan Chowdhury, Zhigang Fang, X. Charlie Dong, Ming O. Li, Suthat Liangpunsakul, Hyeong-Geug Kim
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 921-942 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Sestrin 1/2/3 (Sesn1/2/3) belong to a small family of proteins that have been implicated in the regulation of metabolic homeostasis and oxidative stress. However, the underlying mechanisms remain incompletely understood. The aim of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1574bc0f082fa7f7fd23bf88f6f9c6fc
http://www.sciencedirect.com/science/article/pii/S2352345X21000862
http://www.sciencedirect.com/science/article/pii/S2352345X21000862
Autor:
Irina A. Kirpich, Banrida Wahlang, Nicholas C. Alexander, Xiaohong Li, Matthew C. Cave, Eric C. Rouchka
Publikováno v:
Toxicology Reports, Vol 8, Iss, Pp 536-547 (2021)
Toxicology Reports
Toxicology Reports
Graphical abstract
Highlights • Aroclor1260 worsened diet-induced steatohepatitis in CAR and PXR knockout mice. • CAR and PXR ablation increased gut microbiome diversity and modified composition. • Improved bacterial diversity did not prot
Highlights • Aroclor1260 worsened diet-induced steatohepatitis in CAR and PXR knockout mice. • CAR and PXR ablation increased gut microbiome diversity and modified composition. • Improved bacterial diversity did not prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39015a534cdc9d853739a1ae71598521
http://www.sciencedirect.com/science/article/pii/S2214750021000512
http://www.sciencedirect.com/science/article/pii/S2214750021000512
Akademický článek
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Autor:
Balakrishna L. Lokeshwar, Su Hyeong Kim, Shivendra V. Singh, Krishna B. Singh, Eun-Ryeong Hahm
Publikováno v:
Journal of Traditional and Complementary Medicine
Journal of Traditional and Complementary Medicine, Vol 10, Iss 3, Pp 188-197 (2020)
Journal of Traditional and Complementary Medicine, Vol 10, Iss 3, Pp 188-197 (2020)
Prior research argues for a role of increased de novo fatty acid synthesis in pathogenesis of prostate adenocarcinoma, which remains a leading cause of cancer-associated mortality in American men. A safe and effective inhibitor of fatty acid synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::243c1f07ad39b092a389000f579ecb5f
http://europepmc.org/articles/PMC7340880
http://europepmc.org/articles/PMC7340880
Autor:
Wing-Kee Lee, Michelle Maaß, Amy Quach, Nataliya Poscic, Holly Prangley, Erin-Claire Pallott, Jiyoon L. Kim, Jason S. Pierce, Besim Ogretmen, Anthony H. Futerman, Frank Thévenod
Publikováno v:
The Journal of Biological Chemistry
Oncogenic multidrug resistance (MDR) is commonly intrinsic to renal cancer based on the physiological expression of detoxification transporters, particularly ABCB1, thus hampering chemotherapy. ABCB1 activity is directly dependent on its lipid microe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1819640a96f5d4d5386b5634e205d7
http://europepmc.org/articles/PMC8804196
http://europepmc.org/articles/PMC8804196
Autor:
James E. Goldman, Alice Tang, Michelle L. Olsen, Natasha L. Pacheco, Jiangtao Li, Daniel Flint, Brett S. Phinney, Anthony W. Herren, Fatima Khan, Michael R. Heaven
Publikováno v:
Molecular & cellular proteomics : MCP, vol 21, iss 1
Molecular & Cellular Proteomics : MCP
Molecular & Cellular Proteomics : MCP
Alexander disease (AxD) is a rare and fatal neurodegenerative disorder caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). In this report, a mouse model of AxD (GFAPTg;Gfap+/R236H) was analyzed that contains a heterozygou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27db73f1a1ae5cb5705d0a860adbda89
https://hdl.handle.net/10919/111277
https://hdl.handle.net/10919/111277
Autor:
Nesrin Kartal Ozer, Tugce Demirel-Yalciner, Ceren Avcilar, Tuna Felix Samanci, Dyana Sari, Erdi Sozen
Publikováno v:
Metabolism Open
Metabolism Open, Vol 12, Iss, Pp 100138-(2021)
Metabolism Open, Vol 12, Iss, Pp 100138-(2021)
Objective Increased fatty acid and triglyceride synthesis in liver, majorly modulated by Sterol Regulator Elementing Binding Protein 1c (SREBP1c), is one of the main features of non-alcoholic fatty liver disease (NAFLD). In the present study, we aime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4eac64c79cf8a24a6a6c574d5fc176f
https://pubmed.ncbi.nlm.nih.gov/34704008
https://pubmed.ncbi.nlm.nih.gov/34704008