Zobrazeno 1 - 10
of 89
pro vyhledávání: '"FAS, Fatty acid synthase"'
Publikováno v:
Journal of Advanced Research, Vol 27, Iss, Pp 127-135 (2021)
Journal of Advanced Research
Journal of Advanced Research
Graphical abstract
Background Over the last several decades, hydrogen sulfide (H2S) has been found to exert multiple physiological functions in mammal systems. The endogenous production of H2S is primarily mediated by cystathione β-synthase (CB
Background Over the last several decades, hydrogen sulfide (H2S) has been found to exert multiple physiological functions in mammal systems. The endogenous production of H2S is primarily mediated by cystathione β-synthase (CB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4f72879a610d4ef2b815d4fcf07fdd
https://doi.org/10.1016/j.jare.2020.05.010
https://doi.org/10.1016/j.jare.2020.05.010
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta pharmaceutica Sinica. B, vol 10, iss 1
Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 42-60 (2020)
Acta pharmaceutica Sinica. B, vol 10, iss 1
Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 42-60 (2020)
The hepatic endoplasmic reticulum (ER)-anchored cytochromes P450 (P450s) are mixed-function oxidases engaged in the biotransformation of physiologically relevant endobiotics as well as of myriad xenobiotics of therapeutic and environmental relevance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b693f8b63f9fc633d41381151847be33
https://doi.org/10.1016/j.apsb.2019.11.002
https://doi.org/10.1016/j.apsb.2019.11.002
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 2, Pp 220-236 (2019)
Acta Pharmaceutica Sinica B, Vol 9, Iss 2, Pp 220-236 (2019)
Obesity is increasing in an alarming rate worldwide, which causes higher risks of some diseases, such as type 2 diabetes, cardiovascular diseases, and cancer. Current therapeutic approaches, either pancreatic lipase inhibitors or appetite suppressors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee24ee4e685885a371ae80f1d618f98
https://doi.org/10.1016/j.apsb.2018.09.007
https://doi.org/10.1016/j.apsb.2018.09.007
Autor:
Kendra K. Bence, William P. Esler
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
The prevalence and diagnosis of nonalcoholic fatty liver disease (NAFLD) is on the rise worldwide and currently has no FDA-approved pharmacotherapy. The increase in disease burden of NAFLD and a more severe form of this progressive liver disease, non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14a0440d3ac498ff260c68d959a6ab3
https://doi.org/10.1016/j.jcmgh.2019.04.007
https://doi.org/10.1016/j.jcmgh.2019.04.007
Publikováno v:
JHEP Reports
JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, 2021, 3 (6), pp.100346. ⟨10.1016/j.jhepr.2021.100346⟩
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (6), pp.100346. ⟨10.1016/j.jhepr.2021.100346⟩
JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, 2021, 3 (6), pp.100346. ⟨10.1016/j.jhepr.2021.100346⟩
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (6), pp.100346. ⟨10.1016/j.jhepr.2021.100346⟩
International audience; Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and progressive fibrosis. Several preclinical models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba31673956635c337dc60791ff712432
https://pubmed.ncbi.nlm.nih.gov/34667947
https://pubmed.ncbi.nlm.nih.gov/34667947
Publikováno v:
The Journal of Biological Chemistry
Hepatic glycogen metabolism is impaired in diabetes. We previously demonstrated that strategies to increase liver glycogen content in a high-fat-diet mouse model of obesity and insulin resistance led to a reduction in food intake and ameliorated obes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d848c678125c25105e787106abd7d45d
http://europepmc.org/articles/PMC8027280
http://europepmc.org/articles/PMC8027280
Autor:
Roman Tyshynsky, Shailendra B. Patel, Sithara Raju Ponny, Kirthi Pulakanti, Babu Nageswararao Kanuri, Ranjuna Weerasekera, Kriya S. Patel, Vincent Fong
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100028-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100028-(2021)
The enzyme 3β-hydroxysterol-Δ24 reductase (DHCR24, EC 1.3.1.72) catalyzes the conversion of desmosterol to cholesterol and is obligatory for post-squalene cholesterol synthesis. Genetic loss of this enzyme results in desmosterolosis (MIM #602398),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07891d6a4a13061ce051312bb0c74109
http://europepmc.org/articles/PMC7933790
http://europepmc.org/articles/PMC7933790
Autor:
Steven J. Fliesler, Sriganesh Ramachandra Rao, Sithara Raju Ponny, Ned A. Porter, Shailendra B. Patel, Vincent Fong, Babu Nageswararao Kanuri, Keri A. Tallman
Publikováno v:
Journal of Lipid Research, Vol 62, Iss, Pp 100002-(2021)
Journal of Lipid Research
Journal of Lipid Research
Smith-Lemli-Opitz Syndrome (SLOS) is a developmental disorder (OMIM #270400) caused by autosomal recessive mutations in the Dhcr7 gene, which encodes the enzyme 3β-hydroxysterol-Δ7 reductase. SLOS patients present clinically with dysmorphology and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628669fe15a4d77e5ef7fd0fbdf15f34
http://www.sciencedirect.com/science/article/pii/S0022227520437046
http://www.sciencedirect.com/science/article/pii/S0022227520437046
Publikováno v:
The Journal of Biological Chemistry
The FabG 3-ketoacyl-acyl carrier protein (ACP) reductase of Escherichia coli has long been thought to be a classical member of the short-chain alcohol dehydrogenase/reductase (SDR) family. FabG catalyzes the essential 3-ketoacyl-ACP reduction step in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655561e514680d59e0e361254e86725c
https://pubmed.ncbi.nlm.nih.gov/33545175
https://pubmed.ncbi.nlm.nih.gov/33545175
Publikováno v:
Redox Biology
Redox Biology, Vol 37, Iss, Pp 101749-(2020)
Redox Biology, Vol 37, Iss, Pp 101749-(2020)
Obesity is regarded as an abnormal expansion and excessive accumulation of fat mass in white adipose tissue. The involvement of oxidative stress in the development of obesity is still unclear. Although mainly present in peroxisomes, catalase scavenge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94510a67d93a163b83be3457a2703930
http://europepmc.org/articles/PMC7575809
http://europepmc.org/articles/PMC7575809