BRAF inhibitors enhance erythropoiesis and treat anemia through paradoxical activation of MAPK signaling

Autor: Shunkang Wu, Yuelin Deng, Haobo Sun, Xuewen Liu, Shuo Zhou, Hanxi Zhao, Huan Li, Fusheng Guo, Qiuyu Yue, Fan Wu, Xinying Zhao, Na Li, Shicong Zhu, Qi Hu, Si Xie, Jie Zheng, Meng Lv, Yuan Kong, Xiao-Jun Huang, Xiaoguang Lei, Xiangmin Tong, Xiaofei Gao, Hsiang-Ying Lee

Publikováno v: Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-15 (2024)

Abstract Erythropoiesis is a crucial process in hematopoiesis, yet it remains highly susceptible to disruption by various diseases, which significantly contribute to the global challenges of anemia and blood shortages. Current treatments like erythro

Externí odkaz: https://doaj.org/article/d23ecd989d0a4fee9238f7c221eac04a

Expert Consensus on the Diagnosis and Treatment of FGFR Gene-Altered Solid Tumors

Autor: Chunwei Xu, Bin Lian, Juanjuan Ou, Qian Wang, Wenxian Wang, Ke Wang, Dong Wang, Zhengbo Song, Aijun Liu, Jinpu Yu, Wenzhao Zhong, Zhijie Wang, Yongchang Zhang, Jingjing Liu, Shirong Zhang, Xiuyu Cai, Anwen Liu, Wen Li, Lili Mao, Ping Zhan, Hongbing Liu, Tangfeng Lv, Liyun Miao, Lingfeng Min, Yu Chen, Jingping Yuan, Feng Wang, Zhansheng Jiang, Gen Lin, Long Huang, Xingxiang Pu, Rongbo Lin, Weifeng Liu, Chuangzhou Rao, Dongqing Lv, Zongyang Yu, Xiaoyan Li, Chuanhao Tang, Chengzhi Zhou, Junping Zhang, Junli Xue, Hui Guo, Qian Chu, Rui Meng, Jingxun Wu, Rui Zhang, Jin Zhou, Zhengfei Zhu, Yongheng Li, Hong Qiu, Fan Xia, Yuanyuan Lu, Xiaofeng Chen, Rui Ge, Enyong Dai, Yu Han, Weiwei Pan, Fei Pang, Jintao Huang, Kai Wang, Fan Wu, Bingwei Xu, Liping Wang, Youcai Zhu, Li Lin, Yanru Xie, Xinqing Lin, Jing Cai, Ling Xu, Jisheng Li, Xiaodong Jiao, Kainan Li, Jia Wei, Huijing Feng, Lin Wang, Yingying Du, Wang Yao, Xuefei Shi, Xiaomin Niu, Dongmei Yuan, Yanwen Yao, Jianhui Huang, Yue Feng, Yinbin Zhang, Pingli Sun, Hong Wang, Mingxiang Ye, Zhaofeng Wang, Yue Hao, Zhen Wang, Bin Wan, Donglai Lv, Zhanqiang Zhai, Shengjie Yang, Jing Kang, Jiatao Zhang, Chao Zhang, Lin Shi, Yina Wang, Bihui Li, Zhang Zhang, Zhongwu Li, Zhefeng Liu, Nong Yang, Lin Wu, Huijuan Wang, Gu Jin, Guansong Wang, Jiandong Wang, Meiyu Fang, Yong Fang, Yuan Li, Xiaojia Wang, Jing Chen, Yiping Zhang, Xixu Zhu, Yi Shen, Shenglin Ma, Biyun Wang, Lu Si, Yuanzhi Lu, Ziming Li, Wenfeng Fang, Yong Song

Publikováno v: Global Medical Genetics, Vol 11, Iss 04, Pp 330-343 (2024)

The fibroblast growth factor receptor (FGFR) is a crucial receptor tyrosine kinase involved in essential biological processes, including growth, development, and tissue repair. However, FGFR gene mutations, including amplification, fusion, and mutati

Externí odkaz: https://doaj.org/article/d6d893b96da4470f8696347abc7c0079

Wet-spun Ag/PEDOT: PSS composite fibers for high-sensitive SERS sensing and high electrical conducting

Autor: Fan Wu, Haoyu Shi, Yulong Gao, Lin Cheng, Tongkai Gu, Tong Liu, Ziyun Chen, Wei Fan

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Abstract Nanometal-based composite fibers have been widely explored in flexible sensors due to their outstanding optical and electrical properties. However, the weak binding force between metallic nanomaterial and fiber greatly limits the real applic

Externí odkaz: https://doaj.org/article/bf7d0d8a9a244df294e1b4720ef4bd5b

The ratio between the screw distance and femoral neck width on lateral radiography is a reliable predictor of femoral head necrosis: a clinical review and corresponding numerical simulations

Autor: Hong Li, Shengyu Wan, Jian Zhang, Fan Wu, Xiaozhong Luo, Chao Wu, Xu Lin, Jingchi Li

Publikováno v: Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-10 (2024)

Abstract Background Fixation instability serves as an initial trigger for femoral head necrosis in patients with femoral neck fractures undergoing internal fixation. The configuration of screw trajectories is critical in determining the stability of

Externí odkaz: https://doaj.org/article/7467c94e4ebb41eab337a38c5a99f63d

A collagenase-decorated Cu-based nanotheranostics: remodeling extracellular matrix for optimizing cuproptosis and MRI in pancreatic ductal adenocarcinoma

Autor: Yining Wang, Qiaomei Zhou, Wangping Luo, Xiaoyan Yang, Jinguo Zhang, Yijie Lou, Jin Mao, Jiayi Chen, Fan Wu, Jue Hou, Guping Tang, Hongzhen Bai, Risheng Yu

Publikováno v: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-19 (2024)

Abstract Pancreatic ductal adenocarcinoma (PDAC), characterized by a dense extracellular matrix (ECM), presents significant therapeutic challenges due to its poor prognosis and high resistance to chemotherapy. Current chemodrugs and diagnostic agents

Externí odkaz: https://doaj.org/article/5af075a8b8564352b464016c315b460d