Zobrazeno 1 - 10
of 103
pro vyhledávání: '"FAK, Focal adhesion kinase"'
Autor:
Yihui Gu, Chengjiang Wei, Manhon Chung, Haibo Li, Zizhen Guo, Manmei Long, Yuehua Li, Wei Wang, Rehanguli Aimaier, Qingfeng Li, Zhichao Wang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft-tissue sarcomas which lack effective drugs. Loss of the RAS GTPase-activating protein NF1 and subsequent overactivation of mitogen-activated protein kinase kinase (MAPK) signaling e
Externí odkaz:
https://doaj.org/article/51128f4ec75646b389cc41607f46ccfe
Autor:
Xin Zeng, Lu Sun, Yan-Hua Du, Cheng-cui Huang, Ming-Ming Ma, Hua-Qing Zheng, Yong-Yuan Guan, Ya-juan Zhang, Xiaofei Lv, Xiao-long Li, Guan-Lei Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3994-4007 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Vascular smooth muscle cell (VSMC) migration plays a critical role in the pathogenesis of many cardiovascular diseases. We recently showed that TMEM16A is involved in hypertension-induced cerebrovascular remodeling. However, it is unclear whether thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2252c02263eb5818f231c5b54829c2
http://www.sciencedirect.com/science/article/pii/S2211383521001416
http://www.sciencedirect.com/science/article/pii/S2211383521001416
Publikováno v:
Pancreas
Objectives Pancreatic carcinoma (PC) has become the fourth leading cause of cancer deaths. Long noncoding RNA DUXAP8 has also been reported to play a regulatory role in PC progression. However, its molecular mechanism in PC is not fully elucidated. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2b3d345e75a7689f8ea0e101509e03
http://europepmc.org/articles/PMC8041564
http://europepmc.org/articles/PMC8041564
Autor:
Jiawen Fan, Jie Chen, Lingyuan Zhang, Di Zhao, Weimin Zhang, Yan Wang, Qimin Zhan, Jinting Li
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 143-155 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 143-155 (2021)
Among current novel druggable targets, protein–protein interactions (PPIs) are of considerable and growing interest. Diacylglycerol kinase α (DGKα) interacts with focal adhesion kinase (FAK) band 4.1-ezrin-radixin-moesin (FERM) domain to induce t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1867a51d7e7aeac07cbd99674fa920
https://doi.org/10.1016/j.apsb.2020.07.011
https://doi.org/10.1016/j.apsb.2020.07.011
Publikováno v:
The Journal of Biological Chemistry
Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of deaths across the world. Since the discovery of scarless functional healing in fetuses prior to a certain stage of development, scientists have attempted to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4b6370ffc1bac30359b2b701f66701
https://pubmed.ncbi.nlm.nih.gov/34953859
https://pubmed.ncbi.nlm.nih.gov/34953859
Autor:
Wenting Jia, Baofeng Yang, Yanjie Lu, Yunlong Bai, Jiaming Ju, Lina He, Gulnara Tuguzbaeva, Er Yue, Ying Qin, Yumei Niu, Xi Chen, Xinlei Li, Valentin Pavlov
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 6, Pp 1163-1173 (2019)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Collectively migrating tumor cells have been recently implicated in enhanced metastasis of epithelial malignancies. In oral squamous cell carcinoma (OSCC), αv integrin is a crucial mediator of multicellular clustering and collective movement in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e3e325e5898d0a5ffe340f68daf7d1
http://www.sciencedirect.com/science/article/pii/S2211383519309293
http://www.sciencedirect.com/science/article/pii/S2211383519309293
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 449-467 (2019)
JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 449-467 (2019)
Highlights • Cardiac fibroblasts become activated following injury and participate in repair and remodeling of the heart. • The authors discuss the phenotypic alterations and role of fibroblasts in infarcted and failing hearts. • In failing hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f45f1114d6097027bf0d161c19561f
http://europepmc.org/articles/PMC6610002
http://europepmc.org/articles/PMC6610002
Autor:
Michelle A. Ozbun
Publikováno v:
Papillomavirus Research
Papillomavirus Research, Vol 7, Iss, Pp 188-192 (2019)
Papillomavirus Research, Vol 7, Iss, Pp 188-192 (2019)
Human papillomaviruses (HPVs), like all PVs, predominantly cause benign tumors, or warts, in stratifying squamous epithelial tissues. Virions are released from apical surfaces of the skin and mucosa and, to initiate a new infection, must utilize a br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7251c6de935a25473ff8355606a1b347
http://europepmc.org/articles/PMC6514438
http://europepmc.org/articles/PMC6514438
Autor:
Jeffrey Rubens, David J. Clark, Lijun Chen, Antje Arnold, Micah J. Maxwell, Hui Zhang, Eric H. Raabe, Tung-Shing M. Lih, Michael Schnaubelt, Heather Sweeney, Charles G. Eberhart
Publikováno v:
Molecular & Cellular Proteomics : MCP
The mitogen-activated protein kinase pathway is one of the most frequently altered pathways in cancer. It is involved in the control of cell proliferation, invasion, and metabolism, and can cause resistance to therapy. A number of aggressive malignan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbad6edd54a95268217095d4ba24909d
http://europepmc.org/articles/PMC8363840
http://europepmc.org/articles/PMC8363840
Publikováno v:
Translational Oncology
Translational Oncology, Vol 14, Iss 7, Pp 101096-(2021)
Translational Oncology, Vol 14, Iss 7, Pp 101096-(2021)
Highlights • FOXO3a was down-regulated and TWIST-1 was up-regulated in breast cancer tissues. • Overexpression of FOXO3a suppressed the EMT and metastasis of breast cancer. • Knockdown of TWIST-1 inhibited the EMT and metastasis of breast cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70df0f04d470a09d0748c1247de8c9bc
http://europepmc.org/articles/PMC8081990
http://europepmc.org/articles/PMC8081990