Výsledky vyhledávání - "FAD, flavin adenine dinucleotide"

Akademický článek

Cytochrome b5 reductase is the component from neuronal synaptic plasma membrane vesicles that generates superoxide anion upon stimulation by cytochrome c

Autor: Alejandro K. Samhan-Arias, Sofia Fortalezas, Cristina M. Cordas, Isabel Moura, José J.G. Moura, Carlos Gutierrez-Merino

Publikováno v: Redox Biology, Vol 15, Iss C, Pp 109-114 (2018)

In this work, we measured the effect of cytochrome c on the NADH-dependent superoxide anion production by synaptic plasma membrane vesicles from rat brain. In these membranes, the cytochrome c stimulated NADH-dependent superoxide anion production was

Externí odkaz: https://doaj.org/article/b033fdd96a6146e99223c1498313e4e0

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Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors

Autor: Yi-Chao Zheng, Yue-Jiao Liu, Li-Ying Ma, Yinghua You, Haojie Wang, Hong-Min Liu, Yang Feifei, Chao-Ya Ma

Publikováno v: Acta Pharmaceutica Sinica B, Vol 10, Iss 9, Pp 1658-1668 (2020)
Acta Pharmaceutica Sinica. B

Histone lysine specific demethylase 1 (LSD1) has become a potential therapeutic target for the treatment of cancer. Discovery and develop novel and potent LSD1 inhibitors is a challenge, although several of them have already entered into clinical tri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8ed8f9fce726a289b0ae8847cad43d
https://doi.org/10.1016/j.apsb.2020.02.006

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Improving LC-MS analysis of human milk B-vitamins by lactose removal

Autor: Daniela Hampel, Setareh Shahab-Ferdows, Lindsay H. Allen, John W. Newman

Publikováno v: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences

Highlights • Lactose in human milk affects B-vitamin analysis by fouling the ion source. • Typical extraction methods are inefficient for lactose removal. • Chromatographic separation from analytes enables lactose mechanical removal.
Our p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a775a7be1f6e9d6631488df8f7a98d
https://escholarship.org/uc/item/4hs1917r

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Quantification of NADH:ubiquinone oxidoreductase (complex I) content in biological samples

Autor: Edward Owusu-Ansah, Christian Garcia, Sergey Sosunov, Zoya Niatsetskaya, Anna Stepanova, Vadim Ten, Alexander Galkin, Belem Yoval-Sánchez, Fariha Ansari, Ilka Wittig

Publikováno v: The Journal of Biological Chemistry

Impairments in mitochondrial energy metabolism have been implicated in human genetic diseases associated with mitochondrial and nuclear DNA mutations, neurodegenerative and cardiovascular disorders, diabetes, and aging. Alteration in mitochondrial co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bb0f4587b2ffb9835213ba93fb65a1
http://europepmc.org/articles/PMC8503622

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Amphipol-facilitated elucidation of the functional tetrameric complex of full-length cytochrome P450 CYP2B4 and NADPH-cytochrome P450 oxidoreductase

Autor: Zhiyuan Bo, Yoichi Osawa, Shen Cheng, Haoming Zhang, Paul F. Hollenberg

Publikováno v: The Journal of Biological Chemistry

Interactions of membrane-bound mammalian cytochromes P450 (CYPs) with NADPH-cytochrome P450 oxidoreductase (POR), which are required for metabolism of xenobiotics, are facilitated by membrane lipids. A variety of membrane mimetics, such as phospholip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3f572679c4981e727500ad51da440a
http://europepmc.org/articles/PMC8113742

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Ancestral reconstruction of mammalian FMO1 enables structural determination, revealing unique features that explain its catalytic properties

Autor: Bailleul, Gautier, Nicoll, Callum R., Mascotti, María Laura, Mattevi, Andrea, Fraaije, Marco W.

Publikováno v: Journal of Biological Chemistry
The Journal of Biological Chemistry, 296:100221. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
The Journal of Biological Chemistry

Mammals rely on the oxidative flavin-containing monooxygenases (FMOs) to detoxify numerous and potentially deleterious xenobiotics; this activity extends to many drugs, giving FMOs high pharmacological relevance. However, our knowledge regarding thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d45dc686c62d7c552ab1bdca20fa61

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Natural products as LSD1 inhibitors for cancer therapy

Autor: Xiaochuan Li, Chao Yang, Yuan Fang, Guochao Liao, Bin Yu, Qingchun Mu, Zhiqiang Yu

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 621-631 (2021)
Acta Pharmaceutica Sinica B

Natural products generally fall into the biologically relevant chemical space and always possess novel biological activities, thus making them a rich source of lead compounds for new drug discovery. With the recent technological advances, natural pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee67172081a717a9c2539e0b3e363442
https://pubmed.ncbi.nlm.nih.gov/32837872

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Hysteresis and bistability in the succinate-CoQ reductase activity and reactive oxygen species production in the mitochondrial respiratory complex II

Autor: Miliausha H. Galimova, Lubov N. Markevich, Nikolay I. Markevich

Publikováno v: Redox Biology
Redox Biology, Vol 37, Iss, Pp 101630-(2020)

The mitochondrial respiratory Complex II (CII) is one of key enzymes of cell energy metabolism, linking the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC). CII reversibly oxidizes succinate to fumarate in the TCA cycle and tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de5bd850cb9a42c15099da48d9bc9e4
https://pubmed.ncbi.nlm.nih.gov/32747163

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