Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFα-mediated apoptosis

Autor: Srinivasa T. Reddy, Nicolaos Palaskas, Tomas Ganz, Elizabeta Nemeth, Daniel N. Srole, David Meriwether, Allison L. Fisher

Publikováno v: The Journal of Biological Chemistry
The Journal of biological chemistry, vol 297, iss 4

In plasma, iron is normally bound to transferrin, the principal protein in blood responsible for binding and transporting iron throughout the body. However, in conditions of iron overload when the iron-binding capacity of transferrin is exceeded, non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e0e7ffc71f3ab8b23330c5834f5a41
http://europepmc.org/articles/PMC8463868

Iron Inhibits the Secretion of Apolipoprotein E in Cultured Human Adipocytes

Autor: Janske Reiling, Jingjing He, Jonathan P. Whitehead, V. Nathan Subramaniam, L. Jaskowski, Kim R. Bridle, N. Santrampurwala, Michelle M. Hill, Ahmed Mohamed, Darrell H. G. Crawford, Choaping Ng, Laurence J. Britton, Jayde E. Ruelcke

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, 6(2), 215-217. Elsevier Inc.

Nonalcoholic steatohepatitis (NASH) is characterized by adipose tissue dysfunction with insulin resistance and the dysregulation of adipokines.1 Recent data indicate repartitioning of iron from the liver to adipocytes in obesity and a role for iron i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f0da205f3275611d74375dbe138204
https://doi.org/10.1016/j.jcmgh.2018.04.005

Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients

Autor: Sonia Levi, Valeria Tiranti, Sabrina Dusi, Michela Guaraldo, Barbara Garavaglia, Vania Broccoli, Paolo Santambrogio, Luisa Ida Rotundo

Publikováno v: Neurobiology of Disease
Neurobiology of Disease, Vol 81, Iss, Pp 144-153 (2015)

Pantothenate kinase-associated neurodegeneration is an early onset autosomal recessive movement disorder caused by mutation of the pantothenate kinase-2 gene, which encodes a mitochondrial enzyme involved in coenzyme A synthesis. The disorder is char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47111460d6c550971554646d7eadd0e6

Insights into the role of oxidative stress in the pathology of Friedreich ataxia using peroxidation resistant polyunsaturated fatty acids

Autor: Andrew M. Crabbe, Mikhail S. Shchepinov, M. Grazia Cotticelli, Robert B. Wilson

Publikováno v: Redox Biology
Redox Biology, Vol 1, Iss 1, Pp 398-404 (2013)

Friedreich ataxia is an autosomal recessive, inherited neuro- and cardio-degenerative disorder characterized by progressive ataxia of all four limbs, dysarthria, areflexia, sensory loss, skeletal deformities, and hypertrophic cardiomyopathy. Most dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4804e4de54a697931b4a6da6808713eb

Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD.

Autor: Gupta, Urvi, Ghosh, Sayan, Wallace, Callen T., Shang, Peng, Xin, Ying, Nair, Archana Padmanabhan, Yazdankhah, Meysam, Strizhakova, Anastasia, Ross, Mark A., Liu, Haitao, Hose, Stacey, Stepicheva, Nadezda A., Chowdhury, Olivia, Nemani, Mihir, Maddipatla, Vishnu, Grebe, Rhonda, Das, Manjula, Lathrop, Kira L., Sahel, José-Alain, Zigler Jr, J. Samuel

Publikováno v: Autophagy; Jan2023, Vol. 19 Issue 1, p92-111, 20p