Zobrazeno 1 - 10
of 2 254
pro vyhledávání: '"FAAH"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Background and AimsThis study aimed to develop a prognostic model based on DNA methylation-driven genes for patients with early-stage gastric cancer and to examine immune infiltration and function across varying risk levels.MethodsWe analyzed data fr
Externí odkaz:
https://doaj.org/article/68e478292995416e982ca05a2b7d2a8b
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 2143-2167 (2024)
Hongqing Zhao,1,2,* Yang Liu,1,2,* Na Cai,3 Xiaolin Liao,1,2 Lin Tang,2,4 Yuhong Wang1,2 1Science & Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan, People’s Republic of China; 2Hunan Key Laboratory of Tr
Externí odkaz:
https://doaj.org/article/1fc5f01ea3c946d9b6a6921f4163274d
Autor:
Bala Krishna Prabhala, Jiwan Chettri, Nagalakshmi Irrinki, Abhroop Garg, Rosa Jersie-Christensen, Håvard Jenssen, Biljana Mojsoska, Neeraj Soni, Kristi A. Kohlmeier
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 9, Iss , Pp 100111- (2023)
As part of the brainstem reticular activating system, the laterodorsal tegmentum (LDT) is a central player in regulating sleep, arousal, and motivated behaviors including addiction. The neuronal lipids within the LDT that could regulate neuronal acti
Externí odkaz:
https://doaj.org/article/17aaa5f49ba5415fb8acdfead434e2fe
Publikováno v:
Heliyon, Vol 10, Iss 5, Pp e27363- (2024)
Mushrooms are traditionally used for various medicinal purposes in traditional oriental medicine. The Japanese and Chinese are familiar with the medicinal macro fungus Lentinula edodes (Shiitake mushroom). This study aims to evaluate the role of chem
Externí odkaz:
https://doaj.org/article/3eb05b8ea0ee4b68b4d77b2379c4f0ae
Publikováno v:
Brazilian Journal of Medical and Biological Research, Vol 57 (2024)
Abstract MCH1 is a synthetic macamide that has shown in vitro inhibitory activity on fatty acid amide hydrolase (FAAH), an enzyme responsible for endocannabinoid metabolism. This inhibition can modulate endocannabinoid and dopamine signaling in the n
Externí odkaz:
https://doaj.org/article/31169711f21a448da21ddc2a8aa2115a
Autor:
Altun Beril, Cok Ismet, Noyan Cemal Onur, Kadioglu Ela, Cetin Alptekin, Sengezer Tijen, Altintas Merih, Kurnaz Samet, Dilbaz Nesrin
Publikováno v:
Türk Biyokimya Dergisi, Vol 48, Iss 3, Pp 282-289 (2023)
Given that drug addiction occurs as a result of complex gene-environment interaction, a number of studies claimed that cannabinoid receptor 1 (CNR1), fatty acid amide hydrolase (FAAH), and monoacylglycerol lipase (MGLL) single nucleotide polymorphism
Externí odkaz:
https://doaj.org/article/90a691abf96541ec856015144ec0ad70
Autor:
Irene Santos-García, Carmen Rodríguez-Cueto, Patricia Villegas, Fabiana Piscitelli, Anna Lauritano, Che-Kun J. Shen, Vincenzo Di Marzo, Javier Fernández-Ruiz, Eva de Lago
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-32 (2023)
Abstract Background Frontotemporal dementia (FTD) is a heterogeneous group of early onset and progressive neurodegenerative disorders, characterized by degeneration in the frontal and temporal lobes, which causes deterioration in cognition, personali
Externí odkaz:
https://doaj.org/article/4032d4dbc13a42fda360381499239786
Autor:
Rosaria Greco, Chiara Demartini, Miriam Francavilla, Anna Maria Zanaboni, Sara Facchetti, Michela Palmisani, Valentina Franco, Cristina Tassorelli
Publikováno v:
Cells, Vol 13, Iss 10, p 830 (2024)
The inhibition of endocannabinoid hydrolysis by enzymatic inhibitors may interfere with mechanisms underlying migraine-related pain. The dual FAAH/MAGL inhibitor AKU-005 shows potent inhibitory activity in vitro. Here, we assessed the effect of AKU-0
Externí odkaz:
https://doaj.org/article/a456cb7e44b14148aada90eee6b60749
Autor:
Barbara Emons, Larissa Arning, Vera-Estelle Makulla, Maria-Theresia Suchy, Dimitrios Tsikas, Thomas Lücke, Jörg T. Epplen, Georg Juckel, Patrik Roser
Publikováno v:
Annals of General Psychiatry, Vol 22, Iss 1, Pp 1-9 (2023)
Abstract Background The serotonergic and the endocannabinoid system are involved in the etiology of depression. Depressive patients exhibit low serotonergic activity and decreased level of the endocannabinoids anandamide (AEA) and 2-arachidonylglycer
Externí odkaz:
https://doaj.org/article/bf1f5a46148749258691a5ef704114a2
Autor:
Shenée C. Martin, Kathryn K. Joyce, Kathryn M. Harper, Samuel J. Harp, Todd J. Cohen, Sheryl S. Moy, Graham H. Diering
Publikováno v:
Pharmaceuticals, Vol 17, Iss 3, p 319 (2024)
Sleep disruption is an expected component of aging and neurodegenerative conditions, including Alzheimer’s disease (AD). Sleep disruption has been demonstrated as a driver of AD pathology and cognitive decline. Therefore, treatments designed to mai
Externí odkaz:
https://doaj.org/article/7e26de891f7f48d69a3dc5e4560420ae