Soy supplementation: Impact on gene expression in different tissues of ovariectomized rats and evaluation of the rat model to predict (post)menopausal health effect

Autor: Mohammed A. Islam, Guido J.E.J. Hooiveld, Johannes H.J. van den Berg, Vera van der Velpen, Albertinka J. Murk, Ivonne M.C.M. Rietjens, F.X. Rolaf van Leeuwen

Publikováno v: Toxicology Reports, Vol 5, Iss , Pp 1087-1097 (2018)

This toxicogenomic study was conducted to predict (post)menopausal human health effects of commercial soy supplementation using ovariectomized rats as a model. Different target tissues (i.e. breast, uterus and sternum) and non-target tissues (i.e. pe

Externí odkaz: https://doaj.org/article/c3f9a33186634c888e5ac4292c42ed31

Soy supplementation: Impact on gene expression in different tissues of ovariectomized rats and evaluation of the rat model to predict (post)menopausal health effect

Autor: M.A. Islam, F.X. Rolaf van Leeuwen, Albertinka J. Murk, Vera van der Velpen, Guido J. E. J. Hooiveld, Johannes H.J. van den Berg, Ivonne M.C.M. Rietjens

Publikováno v: Toxicology Reports
Toxicology reports, vol. 5, pp. 1087-1097
Toxicology Reports 5 (2018)
Toxicology Reports, 5, 1087-1097
Toxicology Reports, Vol 5, Iss, Pp 1087-1097 (2018)

Graphical abstract
Highlights • The usefulness of PBMC gene expressions as a surrogate tissue for risk assessment is questionable. • SIF in a dose of 2 mg/kg b.w/day is not able to influence ERGs in target tissues such as breast and uterus.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea48a4dba2d750afbdd316bd0997974c
https://pubmed.ncbi.nlm.nih.gov/30425930

Conversion of major soy isoflavone glucosides and aglycones in in vitro intestinal models

Autor: M.A. Islam, Bert Spenkelink, F.X. Rolaf van Leeuwen, Ans Punt, Albertinka J. Murk, Ivonne M.C.M. Rietjens

Publikováno v: Molecular Nutrition & Food Research, 58(3), 503-515
Molecular Nutrition & Food Research 58 (2014) 3

Scope This study compares conversion of three major soy isoflavone glucosides and their aglycones in a series of in vitro intestinal models. Methods and results In an in vitro human digestion model isoflavone glucosides were not deconjugated, whereas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf56a68fcf757cdcd93efafff3a378b
https://pubmed.ncbi.nlm.nih.gov/24668774

A European perspective on hazardous air pollutants

Autor: F.X Rolaf van Leeuwen

Publikováno v: Toxicology.

Air pollution is considered to be a major threat to human health. Protection of human health from adverse effects of air pollutants and elimination or reduction of exposure to hazardous air pollutants was therefore the major consideration of the Worl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5c151435bf5f360265d7cda587c48e
https://pubmed.ncbi.nlm.nih.gov/12505336

Report of the WHO working group on the assessment of health risks for human infants from exposure to PCDDs, PCDFs and PCBs

Autor: Abraham Brouwer, Ulf G. Ahlborg, F.X. Rolaf van Leeuwen, M. Mark Feeley, Hans Beck, Bram Brouwer, Anders Carlsen, Mark Feeley, Hans Helge, Jens-Jørgen Larsen, John Christian Larsen, Elle Larsen, Dieter Neubert, Maged Younes

Publikováno v: Chemosphere, 37, 1627-1643
Chemosphere 37 (1998)

On Nov. 20-22, 1995, a World Health Organization working group consisting of 12 scientific representatives from 6 different countries met to reassess the health risks to infants associated with perinatal exposure to polyhalogenated aromatic hydrocarb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e6cb8bfd302b98aa74a4c442ddbbb0
https://research.wur.nl/en/publications/report-of-the-who-working-group-on-the-assessment-of-health-risks