Zobrazeno 1 - 10 of 180 pro vyhledávání: '"F.W.H.M. Merkus"'
1
Nasal absorption of hydroxocobalamin in healthy elderly adults
Autor: D.Z.B. van Asselt, F.W.H.M. Merkus, Willibrord H. L. Hoefnagels, Frans G. M. Russel
Publikováno v: British Journal of Clinical Pharmacology, 45, pp. 83-86
British Journal of Clinical Pharmacology, 45, 83-86
Aims To investigate the nasal absorption of hydroxocobalamin in 10 healthy elderly adults. Methods In a cross-over study, blood samples were collected before administration of the drug and after 10, 20, 30, 40, 60, 120, 180 and 240 min. The plasma co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824e8b48e908bba3fea4c6107c324cc4
https://doi.org/10.1046/j.1365-2125.1998.00642.x
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2
Liquid chromatographic determination of β-cyclodextrin derivatives based on fluorescence enhancement after inclusion complexation
Autor: Hubertus Irth, F.W.H.M. Merkus, U.R. Tjaden, H. J. E. M. Reeuwijk, J. van der Greef
Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 614:95-101
A liquid chromatographic method using fluorescence detection for the determination of beta-cyclodextrin (beta CD) and its derivatives is presented. The chromatographic system is based on size-exclusion chromatography with the addition of the fluoroph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b213b38fc4b86b183cb3a541ce6712
https://doi.org/10.1016/0378-4347(93)80227-u
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3
Intranasal hydroxocobalamin administration: an attractive alternative for intramuscular cobalamin injections in geriatric patients
Autor: Willibrord H. L. Hoefnagels, S. Lonterman, Frans G. M. Russel, M.G.M. Olde Rikkert, F.W.H.M. Merkus, D.Z.B. van Asselt
Publikováno v: Drug Development Research, 51, pp. 197-199
Drug Development Research, 51, 197-199
Geriatric patients with a cobalamin deficiency are usually treated with intramuscular vitamin cobalamin injections. This treatment may be painful and requires skilled personnel. This study was designed to investigate the absorption of intranasally ap
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a3e6c4acf4cff0e5e2d3a9aaaa6eeb
https://hdl.handle.net/2066/157104
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4
Transport of peptide and protein drugs across biological membranes
Autor: F.W.H.M. Merkus, D. D. Breimer, Joke A. Bouwstra, Harry E. Boddé, A. G. De Boer, J.C. Verhoef, Hans E. Junginger
Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 15:83-93
The transport characteristics of peptide and proteins drugs across various epithelial membrane barriers are outlines. These include transport through the intestinal, buccal, nasal and pulmonary absorptive mucosae, as well as transdermal penetration.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010967c96ad4b5ce9078d831540c75bc
https://doi.org/10.1007/bf03190191
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5
Nasal absorption of hydroxocobalamin in healthy older adults
Autor: F.W.H.M. Merkus, D.Z.B. van Asselt, Willibrord H. L. Hoefnagels
Publikováno v: Age and Ageing, 26, 1, pp. 24-24
Age and Ageing, 26, 24-24
Contains fulltext : 24477___.PDF (Publisher’s version ) (Open Access)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b8e3365da1a1f04ceff60da24eca2e
https://hdl.handle.net/2066/24477
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8
Determination of the serum concentration of spironolactone and its metabolites by high-performance liquid chromatography
Autor: F.W.H.M. Merkus, W.A.J.J. Hermens, J.W.P.M. Overdiek
Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 341:279-285
A simple and rapid high-performance liquid chromatographic assay is described for the simultaneous determination in serum of the aldosterone antagonist spironolactone and its metabolites 7 alpha-thiomethylspirolactone, 6 beta-hydroxy-7 alpha-thiometh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97b1d4266fe9b03449a0fe69495671c
https://doi.org/10.1016/s0378-4347(00)84041-4
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