Zobrazeno 1 - 10 of 104 pro vyhledávání: '"F.W. Schueler"'
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Pharmacological Studies on Some New Azlactone Derivatives
Autor: G. Alan Robison, F.W. Schueler
Publikováno v: Journal of Pharmaceutical Sciences. 50:602-605
Several members of a new series of azlactone derivatives (substituted acrylic acid amides), which by themselves exhibit convulsant properties, were found to be capable of prolonging the duration of hexobarbital-induced hypnosis in mice. Experiments a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48524bbbeb8eafec5147e807e8e5e594
https://doi.org/10.1002/jps.2600500716
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3
Chemical Constitution and Analgetic Action
Autor: H. Holland, E.G. Gross, F.W. Schueler
Publikováno v: Journal of the American Pharmaceutical Association (Scientific ed.). 38:74-81
The relation between chemical constitution and analgetic action has been investigated in several compound types which bear a Structural relationship to the morphine-type analgetics. Analgetic potency has been demonstrated in several compound types.
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https://doi.org/10.1002/jps.3030380207
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4
Synthesis and Metabolic Studies of Cl4-Labeled Hemicholinium Number Three**Received August 28, 1959, from Tulane University, School of Medicine, New Orleans 12, La
Autor: F.W. Schueler, Floyd R. Domer
Publikováno v: Journal of the American Pharmaceutical Association (Scientific ed.). 49:553-556
Synthesis of C I4 -labeled hemicholinium No. 3 (HC-3) with a specific activity of 2.788 mc./m M is described. Twenty-four hour studies of rats in metabolism cages indicated 57.5 per cent of an injected dose is excreted in the urine, 15.6 per cent is
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https://doi.org/10.1002/jps.3030490817
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5
The Polymerization of Pharmacophoric Moieties and Its Effect Upon Biologic Activity I. Polymeric Quaternary Ammonium Salts**Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City
Autor: H. H. Keasling, F.W. Schueler
Publikováno v: Journal of the American Pharmaceutical Association (Scientific ed.). 45:792-796
A group of polymeric quaternary ammonium salts have been synthesized and studied pharmacologically. The polymers exhibited a high degree of neuromuscular blocking potency. The results have been discussed both in regard to their theoretic and practica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e9f0e44cd8bb1e432107883da69809b
https://doi.org/10.1002/jps.3030451207
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6
Synthesis and Evaluation of a New Ganglionic Blocking Agent*
Autor: F.W. Schueler, H. H. Keasling
Publikováno v: Journal of the American Pharmaceutical Association (Scientific ed.). 43:98-101
Details concerning the synthesis and pharmacologic evaluation of a new hexamethonium ganglionic blocking agent containing a "built-in" muscarinic moiety are described. The inclusion of this latter moiety may be regarded as an attempt to increase para
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0902c6d8801506045298df9a165f7ec
https://doi.org/10.1002/jps.3030430208
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7
A New Series of Cholinesterase Inhibitors*
Autor: F.W. Schueler, John P. Long
Publikováno v: Journal of the American Pharmaceutical Association (Scientific ed.). 43:79-86
In a series of bis onium biphepyl derivatives, alteration of substitutions on the quaternary nitrogen produced a wide variation in toxicity and ability to inhibit cholinesterase, as well as other pharmacological responses. Three members of this serie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9cc84e6c6b791f42000db6d8c19702d
https://doi.org/10.1002/jps.3030430204
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8
Pharmacological Studies of Norphenyl Hemicholinium 3
Autor: S. N. Thampi, Floyd R. Domer, F.W. Schueler, Vernon B. Haarstad
Publikováno v: Journal of Pharmaceutical Sciences. 55:381-386
Norphenyl HC-3 (NP-HC-3), an analog of HC-3 in which the biphenyl nucleus is replaced by a monophenyl moiety, has been synthesized. NP-HC-3 has been shown to resemble the parent compound in most of its pharmacological properties. Its LD50 in mice was
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf047fd6855732c807074f7555f8b5a
https://doi.org/10.1002/jps.2600550406
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9
The Relationship Between Estrogenic Action and Chemical Constitution in a Group of Azomethine Derivatives††This work was aided by a grant from the United States Public Health Service.‡‡Preliminary Report, Federation Proc.. 8 (1), 306(1949)
Autor: H. H. Keasling, F.W. Schueler
Publikováno v: Journal of the American Pharmaceutical Association (Scientific ed.). 39:87-90
The relation between chemical constitution and estrogenic action has been investigated in a group of azomethine derivatives comprising all 4,4′ substitution combinations of four groups—H, CH3, CH3O, OH. 4,4′-Dihydroxy benzylidene aniline produc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34fcf35b8a9cb1eb06e71a9a7aecb518
https://doi.org/10.1002/jps.3030390209
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