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of 54
pro vyhledávání: '"F.J.G.M. Kubben"'
Akademický článek
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Autor:
Cornelis F. M. Sier, W. van Duijn, Lukas J. A. C. Hawinkels, James C. H. Hardwick, Alexandra M. J. Langers, F.J.G.M. Kubben, H. W. Verspaget, Daan W. Hommes, J. J. van der Reijden
Publikováno v:
British Journal of Cancer, 106(9), 1495-1498
British Journal of Cancer
British Journal of Cancer
Background: Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. Methods: We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18840b661106cc6da0f645072890aa14
https://doi.org/10.1038/bjc.2012.80
https://doi.org/10.1038/bjc.2012.80
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Alexandra M. J. Langers, Daan W. Hommes, Lukas J. A. C. Hawinkels, Cornelis F. M. Sier, F.J.G.M. Kubben, J. J. van der Reijden, Hein W. Verspaget, W. van Duijn, Cornelis B.H.W. Lamers
Publikováno v:
British Journal of Cancer
The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2(-1306T) and high MMP-2 levels were significantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea9a75208a901f63ff88cd61b0693f1
http://europepmc.org/articles/PMC2410128
http://europepmc.org/articles/PMC2410128
Autor:
W. van Duijn, F.J.G.M. Kubben, Kim Zuidwijk, Lukas J. A. C. Hawinkels, Hein W. Verspaget, Jan H. Verheijen, Cornelis B.H.W. Lamers, J. M. Van Der Zon, Daan W. Hommes, Cornelis F. M. Sier
Publikováno v:
British Journal of Cancer, 3, 97, 398-404
British Journal of Cancer
British Journal of Cancer
Transforming growth factor-beta1 (TGF-beta1), a tumour suppressing as well as tumour-promoting cytokine, is stored as an extracellular matrix-bound latent complex. We examined TGF-beta1 activation and localisation of TGF-beta1 activity in gastric can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b9ba36400f5849d45bd364f6893f35
https://doi.org/10.1038/sj.bjc.6603877
https://doi.org/10.1038/sj.bjc.6603877
Autor:
J. J. van der Reijden, Cornelis F. M. Sier, Hein W. Verspaget, M.J.W. Meijer, Cornelis B.H.W. Lamers, F.J.G.M. Kubben, Gerrit Griffioen, M. van den Berg, C.J.H. van de Velde
Publikováno v:
British Journal of Cancer
Gastric cancers express enhanced levels of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). Single-nucleotide polymorphisms (SNPs) in MMP and TIMP genes may be associated with disease susceptibility and might also affect their an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf795bcc080128475a54f53e469f158e
https://doi.org/10.1038/sj.bjc.6603307
https://doi.org/10.1038/sj.bjc.6603307
Autor:
Hein W. Verspaget, R. A. van Hogezand, Cornelis B.H.W. Lamers, L. Kruidenier, M. van den Berg, W. van Duijn, Cornelis F. M. Sier, M.J.W. Meijer, F.J.G.M. Kubben, Qiang Gao
Publikováno v:
Digestive and Liver Disease. 37:584-592
Background/aims. Matrix metalloproteinases are major contributors in the breakdown and reconstitution of basement membranes and extracellular matrix in pathophysiological processes. We assessed the expression of matrix metalloproteinases-2 and -9 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c89986be6638df5250efdc3d04f7439
https://doi.org/10.1016/j.dld.2005.02.011
https://doi.org/10.1016/j.dld.2005.02.011
Autor:
Cornelis F. M. Sier, C.J.H. van de Velde, A. M. L. Janssen, Gerrit Griffioen, Cornelis B.H.W. Lamers, H. W. Verspaget, C. B. Bosman, J.H.J.M. van Krieken, F.J.G.M. Kubben
Publikováno v:
British Journal of Cancer
Reactive oxygen metabolites are implicated in the initiation and promotion of cancer. In addition, oxidant scavengers, such as manganese--(Mn-SOD) and copper/zinc--superoxide dismutase (Cu/Zn-SOD), are thought to contribute to colorectal cancer treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef81d793852877a4fc4b37f0388c4dfb
https://doi.org/10.1038/bjc.1998.626
https://doi.org/10.1038/bjc.1998.626
Autor:
Peter J. K. Kuppen, F.J.G.M. Kubben, S. Ganesh, Hein W. Verspaget, Alexander L. Vahrmeijer, Martin C. Boonstra, Cornelis F. M. Sier, Cornelis J.H. van de Velde, Paul H.A. Quax
Publikováno v:
Current Pharmaceutical Design, 17(19), 1890-1910
Since decades the urokinase plasminogen activator (uPA) system has been associated with the invasion of malignant cells. The receptor of urokinase (uPAR) is one of the key players in this proteolytic cascade, because it focuses uPA's proteolytic acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d7a63b34437ea1d85d438837dc9f45
https://pubmed.ncbi.nlm.nih.gov/21711239
https://pubmed.ncbi.nlm.nih.gov/21711239
Eradication of Helicobacter pylori infection favourably affects altered gastric mucosal MMP-9 levels
Autor:
Jan H. Verheijen, Hein W. Verspaget, Cornelis F. M. Sier, Roeland Hanemaaijer, T. Anne M. C. Witte, Cornelis B.H.W. Lamers, Wim van Duijn, F.J.G.M. Kubben, Miranda T. Schram, Roeland A. Veenendaal
Publikováno v:
Helicobacter. 12(5)
Background: Helicobacter pylori gastritis is recognized as an important pathogenetic factor in peptic ulcer disease and gastric carcinogenesis, and is accompanied by strongly enhanced gastric mucosal matrix metalloproteinase-9 (MMP-9) levels. Aim: Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d5f608e92e5863f2de0429d155aff8
https://pubmed.ncbi.nlm.nih.gov/17760717
https://pubmed.ncbi.nlm.nih.gov/17760717