Zobrazeno 1 - 10
of 54
pro vyhledávání: '"F.J. Fernandez-Gomez"'
Autor:
F.J. Fernandez-Gomez, M.D. Pastor, E.M. Garcia-Martinez, R. Melero-Fernandez de Mera, M. Gou-Fabregas, M. Gomez-Lazaro, S. Calvo, R.M. Soler, M.F. Galindo, J. Jordán
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 2, Pp 296-307 (2006)
Parkinson disease (PD) is the second-most common age-related neurodegenerative disease and is characterized by the selective destruction of dopaminergic neurons. Increasing evidence indicates that oxidative stress plays a crucial role in the pathogen
Externí odkaz:
https://doaj.org/article/75d0a6946e4c4b029a1f7bff70c0d0aa
Autor:
F.J. Fernandez-Gomez, M. Gomez-Lazaro, D. Pastor, S. Calvo, N. Aguirre, M.F. Galindo, J. Jordán
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 384-391 (2005)
Experimental and clinical studies support the view that the semisynthetic tetracycline minocycline exhibits neuroprotective roles in several models of neurodegenerative diseases, including ischemia, Huntington, Parkinson diseases, and amyotrophic lat
Externí odkaz:
https://doaj.org/article/2ca78f5ed1bc4179807976ad0ae732b9
Autor:
Carmen Belen Alvarez-Simón, Helena Mira, F.J. Fernandez-Gomez, María Díaz-Moreno, Francisco Sánchez-Sánchez, Vicente Blanco, Paloma Honrubia-Gómez, Carmen Ramírez-Castillejo, Joaquín Jordán, Francisco Almeida, Juan Carlos Castillo Cano, Paola Castro-Garcia, Carmen Gil-Gas
Publikováno v:
The FASEB Journal. 29:1480-1492
We studied potential changes in the subventricular zone (SVZ) stem cell niche of the senescence-accelerated mouse prone-8 (SAM-P8) aging model. Bromodeoxyuridine (BrdU) assays with longtime survival revealed a lower number of label-retaining stem cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10797ba65615c514341819c664a1fb6b
https://doi.org/10.1096/fj.13-244442
https://doi.org/10.1096/fj.13-244442
Akademický článek
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Autor:
Cecilio J. Vidal, Joaquín Jordán, María F. Montenegro, Encarnación Muñoz-Delgado, Francisco J. Campoy, F.J. Fernandez-Gomez
Publikováno v:
Journal of Neuroscience Research. 88:155-166
The early-onset, irreversible, severe deficits of learning and memory in the senescence-accelerated mouse (SAM)-prone/8 (SAMP8) support its use as an animal model for human dementias of early onset. Possible implication of acetylcholinesterase (AChE)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d48254fc59f8d020a2c909915d673e2
https://doi.org/10.1002/jnr.22177
https://doi.org/10.1002/jnr.22177
Autor:
Encarnación Muñoz-Delgado, Cecilio J. Vidal, Joaquín Jordán, Francisco J. Campoy, María F. Montenegro, F.J. Fernandez-Gomez
Publikováno v:
Chemico-Biological Interactions. 175:332-335
Looking at cholinesterases (ChEs) changes in age-related mental impairment, the expression of ChEs in brain of senescence accelerated-resistant (SAMR1) and senescence accelerated-prone (SAMP8) mice was studied. Acetylcholinesterase (AChE) activity wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738b1510a6f59669f4abccb8e7f185e6
https://doi.org/10.1016/j.cbi.2008.05.010
https://doi.org/10.1016/j.cbi.2008.05.010
Autor:
F.J. Fernandez-Gomez, Maria F. Galindo, Nuria Llecha, Miguel F. Segura, Joaquín Jordán, Joan X. Comella, Jochen H. M. Prehn, Caoimhín G. Concannon, Maria Gomez-Lazaro
Publikováno v:
Journal of Neurochemistry. 104:1599-1612
Mitochondrial alterations have been associated with the cytotoxic effect of 6-hydroxydopamine (6-OHDA), a widely used toxin to study Parkinson's disease. In previous work, we have demonstrated that 6-OHDA increases mitochondrial membrane permeability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a36a13fcd91abce95a4a7a870eb4eaf6
https://doi.org/10.1111/j.1471-4159.2007.05115.x
https://doi.org/10.1111/j.1471-4159.2007.05115.x
Autor:
Javier Egea, José Sánchez-Prieto, Luis Gandía, Joaquín Jordán, María del Carmen Godino, Jesús M. Hernández-Guijo, F.J. Fernandez-Gomez, Jose Carlos Gonzalez, Antonio G. García
Publikováno v:
European Journal of Neuroscience. 26:2481-2495
The mechanism of the neuroprotective action of the tetracycline antibiotic minocycline against various neuron insults is controversial. In an attempt to clarify this mechanism, we have studied here its effects on various electrophysiological paramete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09bb7b27c170652e537404f83f2f05d9
https://doi.org/10.1111/j.1460-9568.2007.05873.x
https://doi.org/10.1111/j.1460-9568.2007.05873.x
Autor:
Maria F. Galindo, Joaquín Jordán, Ichiro Ikuta, María Jiménez Ramos, Norberto Aguirre, F.J. Fernandez-Gomez
Publikováno v:
Current Drug Delivery. 4:225-231
In this review we explore and integrate the knowledge of the plausible pharmacological targets that could explain the new application for the well known semi-synthetic, tetracycline-derivate minocycline as a cytoprotective drug. In doing so, we will
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9967ab77de6399df6de8e5775c237767
https://doi.org/10.2174/156720107781023938
https://doi.org/10.2174/156720107781023938
Autor:
F.J. Fernandez-Gomez, Jochen H. M. Prehn, Maria F. Galindo, Maria Gomez-Lazaro, Miguel F. Segura, Joan X. Comella, R. M. Melero-Fernandez de Mera, Joaquín Jordán, Caoimhín G. Concannon
Publikováno v:
Molecular Pharmacology. 71:736-743
Malonate, an inhibitor of mitochondrial complex II, is a widely used toxin to study neurodegeneration in Huntington's disease and ischemic stroke. We have shown previously that malonate increased reactive oxygen species (ROS) production in human SH-S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73642138670a4fd2a5017f28e7a26d04
https://doi.org/10.1124/mol.106.030718
https://doi.org/10.1124/mol.106.030718