Výsledky vyhledávání - "F. van Aelst"

Survival of patients with metastatic breast cancer: a single-centre experience

Autor: N. Mortier, I. Spoormans, F Van Aelst, N. Neyens, R. D’hondt

Publikováno v: Acta Clinica Belgica. 69:194-199

Metastatic breast cancer (MBC) remains an incurable disease, despite major advances in the treatment in the past 10-12 years. Data on real life overall survival in a non-selected group containing all metastatic breast cancer patients are hard to find

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa334268d41bfb0ef9cbace0deb6cb0
https://doi.org/10.1179/2295333714y.0000000016

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Synthesis and conformational analysis of an analogue of the antithrombin-binding region of heparin: The role of the carboxylate function of α-L-idopyranuronate

Autor: Hans Lucas, Gerard N. Wagenaars, S. F. Van Aelst, M. W. P. van den Nieuwenhof, J.-R. Mellema, C. A. A. Van Boeckel

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 106:581-591

An analogue of the antithrombin-III-binding region of heparin has been synthesized. This analogue [GlcNSO3 (6-OSO3)-GlcU-GlcNSO3 (3,6-OSO3)-Xyl(2-OSO3)-GlcNSO3 (6-OSO3), i.e. compound 11] lacks the carboxylate function of the α-L-iduronic acid moiet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5292364d29befad806a4a086b9ceffac
https://doi.org/10.1002/recl.19871061107

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Observational Aranesp® Survey to Investigate the Q3W Schedule (OASIS): a prospective observational study of treatment of chemotherapy-induced anaemia with every 3 weeks darbepoetin alfa

Autor: Johan Vansteenkiste, Beatrijs Anrys, D Verhoeven, K Segers, D Verhulst, F Van Aelst, K. van Eygen, D. Galdermans, K Pat, M Polus, Isabelle Wauters, M. P Derde

Publikováno v: Supportive Care in Cancer. 17:211-215

This prospective observational study examined the adherence to published European guidelines on erythropoiesis-stimulating agents (ESAs) and the pattern of use and effect of darbepoetin alfa (DA) 500 microg once every 3 weeks (Q3W) for the treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b7fce9ba487d717c4c20a3c40f8bfa
https://doi.org/10.1007/s00520-008-0517-y

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A randomized phase II study of alternating and sequential regimens of docetaxel and doxorubicin as first-line chemotherapy for metastatic breast cancer

Autor: P. Willemse, C. Ramazeilles, V. Georgoulias, Veronique Cocquyt, Y. Boudraa, H. Hausmaninger, Robert Paridaens, Christoph C. Zielinski, J. Wildiers, F Van Aelst, N. Azli, H. Samonnig

Publikováno v: Annals of Oncology, 14(3), 433-440. Oxford University Press

Background: This phase II study evaluated the feasibility and efficacy of alternating and sequential regimens of docetaxel and doxorubicin as first-line chemotherapy for metastatic breast cancer (MBC).Patients and methods: Women with MBC requiring fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1516327c11b270eca5a2615958168e
https://doi.org/10.1093/annonc/mdg111

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Unique Overlap in the Prerequisites for Thrombin Inhibition and Oral Bioavailability Resulting in Potent Oral Antithrombotics

Autor: Jan Kelder, Sjoerd F. van Aelst, Co A.M. Peters, Theo G. van Dinther, Peter D. J. Grootenhuis, A. Visser, Hans Lucas, Anton E.P. Adang, Johannes Bernardus Maria Rewinkel, D.G. Meuleman, Martin J. Smit, Adrianus Petrus Antonius De Man, G.M.T. Vogel, Constant A. A. van Boeckel

Publikováno v: Journal of Medicinal Chemistry. 45:4419-4432

Despite intense research over the last 10 years, aided by the availability of X-ray structures of enzyme-inhibitor complexes, only very few truly orally active thrombin inhibitors have been found. We conducted a comprehensive study starting with pept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b8dd5256b1dcd877b95198f2ee775e
https://doi.org/10.1021/jm011110z

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Synthesis of an analogue of the antithrombin binding region of heparin containing α-L-idopyranose

Autor: C. A. A. Van Boeckel, S. F. Van Aelst

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 106:593-595

The synthesis of a heparin-like pentasaccharide, containing 2,6-di-O-sulphated α-L-idopyranose instead of the naturally occurring 2-O-sulphated α-L-idopyranuronate, is described. Although conformational properties of these compounds are similar, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17d05b0c7d6f5036d8bebf76b61fe51a
https://doi.org/10.1002/recl.19871061108

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