Zobrazeno 1 - 10
of 709
pro vyhledávání: '"F. de Vos"'
Autor:
Erik H. A. Michels, Osoul Chouchane, Justin de Brabander, Alex F. de Vos, Daniël R. Faber, Renée A. Douma, Eva R. Smit, W. Joost Wiersinga, Maartje van den Biggelaar, Tom van der Poll, Arie J. Hoogendijk
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionNeutrophils play a dichotomous role in community-acquired pneumonia (CAP), providing protection and potentially causing damage. Existing research on neutrophil function in CAP relies on animal studies, leaving a gap in patient-centered in
Externí odkaz:
https://doaj.org/article/82da1f3eae65400f9cacb7010bc64673
Autor:
Christine C. A. van Linge, Robert F.J. Kullberg, Osoul Chouchane, Joris J. T. H. Roelofs, Wil H. F. Goessens, Cornelis van ‘t Veer, Jean-Claude Sirard, Alex F. de Vos, Tom van der Poll
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectiveAntimicrobial resistance is an emerging problem and multi-drug resistant (MDR) Klebsiella pneumoniae (K. pneumoniae) represents an enormous risk of failing therapy in hospital-acquired pneumonia. The current study aimed to determine the immu
Externí odkaz:
https://doaj.org/article/4c29503838964b84965265ad5b1f23b3
Autor:
Ivan Ramirez-Moral, Alex R. Schuurman, Christine C.A. van Linge, Joe M. Butler, Xiao Yu, Karen de Haan, Sarah van Leeuwen, Alex F. de Vos, Menno D. de Jong, Felipe A. Vieira Braga, Tom van der Poll
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110662- (2024)
Summary: Airway epithelial cells represent the first line of defense against respiratory pathogens. Flagellin drives the motility of many mucosal pathogens and has been suggested as an immune enhancing adjunctive therapeutic in infections of the airw
Externí odkaz:
https://doaj.org/article/819ebe64dbea43b881ff22d0a2d42a13
Autor:
Berke Gürkan, Hessel Poelman, Liza Pereverzeva, Danielle Kruijswijk, Alex F. de Vos, Anouk G. Groenen, Edgar E. Nollet, Kanin Wichapong, Esther Lutgens, Tom van der Poll, Jiangfeng Du, W. Joost Wiersinga, Gerry A. F. Nicolaes, Cornelis van ‘t Veer
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2024)
The anti-inflammatory interleukin-1 receptor associated kinase-M (IRAK-M) is a negative regulator of MyD88/IRAK-4/IRAK-1 signaling. However, IRAK-M has also been reported to activate NF-κB through the MyD88/IRAK-4/IRAK-M myddosome in a MEKK-3 depend
Externí odkaz:
https://doaj.org/article/0c33abacff5a46efbd205dff44b03560
Autor:
Mark P. van Opijnen, Marike L. D. Broekman, Filip Y. F. de Vos, Edwin Cuppen, Jacobus J. M. van der Hoeven, Myra E. van Linde, Annette Compter, Laurens V. Beerepoot, Martin J. van den Bent, Maaike J. Vos, Helle-Brit Fiebrich, Johan A. F. Koekkoek, Ann Hoeben, Kuan H. Kho, Chantal M. L. Driessen, Hanne-Rinck Jeltema, Pierre A. J. T. Robe, Sybren L. N. Maas
Publikováno v:
BMC Medical Genomics, Vol 15, Iss 1, Pp 1-8 (2022)
Abstract Background Glioblastoma (GBM), the most common glial primary brain tumour, is without exception lethal. Every year approximately 600 patients are diagnosed with this heterogeneous disease in The Netherlands. Despite neurosurgery, chemo -and
Externí odkaz:
https://doaj.org/article/cfe094ec48aa400ca623264ad921e979
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Liver kinase B1 (Lkb1, gene name Stk11) functions as a tumor suppressor in cancer. Myeloid cell Lkb1 potentiates lung inflammation induced by the Gram-negative bacterial cell wall component lipopolysaccharide and in host defense d
Externí odkaz:
https://doaj.org/article/dd7daa0e6d3549e3aee653179b7be5a3
Autor:
Alex R. Schuurman, Joe M. Butler, Erik H.A. Michels, Natasja A. Otto, Xanthe Brands, Bastiaan W. Haak, Fabrice Uhel, Augustijn M. Klarenbeek, Daniël R. Faber, Bauke V. Schomakers, Michel van Weeghel, Alex F. de Vos, Brendon P. Scicluna, Riekelt H. Houtkooper, W. Joost Wiersinga, Tom van der Poll
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107181- (2023)
Summary: Neutrophils are potent immune cells with key antimicrobial functions. Previous in vitro work has shown that neutrophil effector functions are mainly fueled by intracellular glycolysis. Little is known about the state of neutrophils still in
Externí odkaz:
https://doaj.org/article/4e949718e4164c9fb99adf50b5dffd0d
Autor:
Zhe Liu, Alexander P.N.A. De Porto, Regina De Beer, Joris J.T.H. Roelofs, Onno J. De Boer, Sandrine Florquin, Cornelis Van’t Veer, Rudi W. Hendriks, Tom Van der Poll, Alex F. De Vos
Publikováno v:
Journal of Innate Immunity, Pp 1-15 (2022)
Humans with dysfunctional Bruton’s tyrosine kinase (Btk) are highly susceptible to bacterial infections. Compelling evidence indicates that Btk is essential for B cell-mediated immunity, whereas its role in myeloid cell-mediated immunity against in
Externí odkaz:
https://doaj.org/article/9a182f02185d4c06a7e0960e061482bc
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-4 (2021)
Abstract Agonists of peroxisome proliferator-activated receptor (PPAR)-γ have been suggested as potential adjuvant therapy in bacterial pneumonia because of their capacity to inhibit inflammation and enhance bacterial clearance. Previous studies onl
Externí odkaz:
https://doaj.org/article/b697a7efe2fb46b8bacff604b72b004f
Autor:
Erik Malmström, Hina N. Khan, Cornelis van ‘t Veer, Melissa Stunnenberg, Mariska T. Meijer, Hisatake Matsumoto, Natasja A. Otto, Teunis B. H. Geijtenbeek, Alex F. de Vos, Tom van der Poll, Brendon P. Scicluna
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Monocytes are key players in innate immunity, with their ability to regulate inflammatory responses and combat invading pathogens. There is a growing body of evidence indicating that long non-coding RNA (lncRNA) participate in various cellular biolog
Externí odkaz:
https://doaj.org/article/c0649fcb53b14359bb3fa75fc522758e